A nationwide, multi-center, retrospective study of symptomatic small bowel stricture in patients with Crohn’s disease

Shigeki Bamba, Ryosuke Sakemi, Toshimitsu Fujii, Teruyuki Takeda, Shin Fujioka, Kento Takenaka, Hiroki Kitamoto, Shotaro Umezawa, Hirotake Sakuraba, Toshihiro Inokuchi, Norimasa Fukata, Shinta Mizuno, Masaki Yamashita, Shinichiro Shinzaki, Hiroki Tanaka, Hidetoshi Takedatsu, Ryo Ozaki, Kei Moriya, Manabu Ishii, Tetsu KinjoKeiji Ozeki, Makoto Ooi, Ryohei Hayashi, Kazuki Kakimoto, Yuichi Shimodate, Kazuya Kitamura, Akihiro Yamada, Akira Sonoda, Yu Nishida, Kyouko Yoshioka, Shinya Ashizuka, Fumiaki Takahashi, Toshio Shimokawa, Taku Kobayashi, Akira Andoh, Toshifumi Hibi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Small bowel stricture is one of the most common complications in patients with Crohn’s disease (CD). Endoscopic balloon dilatation (EBD) is a minimally invasive treatment intended to avoid surgery; however, whether EBD prevents subsequent surgery remains unclear. We aimed to reveal the factors contributing to surgery in patients with small bowel stricture and the factors associated with subsequent surgery after initial EBD. Methods: Data were retrospectively collected from surgically untreated CD patients who developed symptomatic small bowel stricture after 2008 when the use of balloon-assisted enteroscopy and maintenance therapy with anti-tumor necrosis factor (TNF) became available. Results: A total of 305 cases from 32 tertiary referral centers were enrolled. Cumulative surgery-free survival was 74.0% at 1 year, 54.4% at 5 years, and 44.3% at 10 years. The factors associated with avoiding surgery were non-stricturing, non-penetrating disease at onset, mild severity of symptoms, successful EBD, stricture length < 2 cm, and immunomodulator or anti-TNF added after onset of obstructive symptoms. In 95 cases with successful initial EBD, longer EBD interval was associated with lower risk of surgery. Receiver operating characteristic analysis revealed that an EBD interval of ≤ 446 days predicted subsequent surgery, and the proportion of smokers was significantly high in patients who required frequent dilatation. Conclusions: In CD patients with symptomatic small bowel stricture, addition of immunomodulator or anti-TNF and smoking cessation may improve the outcome of symptomatic small bowel stricture, by avoiding frequent EBD and subsequent surgery after initial EBD.

Original languageEnglish
Pages (from-to)615-626
Number of pages12
JournalJournal of Gastroenterology
Volume55
Issue number6
DOIs
Publication statusPublished - Jun 1 2020

Keywords

  • Balloon enteroscope
  • Inflammatory bowel disease
  • Stenosis

ASJC Scopus subject areas

  • Gastroenterology

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