Abstract
Flow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulsewave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus. In total, we estimate that approximately 4000 Japanese subjects in 3 different study groups will eventually be enrolled in this prospective observational investigation. We anticipate that the present study will provide important evidence for the usefulness of FMD measurement in the risk stratification for cardiovascular disease.
| Original language | English |
|---|---|
| Pages (from-to) | 170-175 |
| Number of pages | 6 |
| Journal | International Heart Journal |
| Volume | 53 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Carotid atherosclerosis
- Coronary artery disease
- Endothelium
- Flow-mediated vasodilatation
- Hypertension
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery. / Tomiyama, Hirofumi; Kohro, Takahide; Higashi, Yukihito; Takase, Bonpei; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Itoh, Hiroshi; Yamashina, Akira.
In: International Heart Journal, Vol. 53, No. 3, 2012, p. 170-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery
AU - Tomiyama, Hirofumi
AU - Kohro, Takahide
AU - Higashi, Yukihito
AU - Takase, Bonpei
AU - Suzuki, Toru
AU - Ishizu, Tomoko
AU - Ueda, Shinichiro
AU - Yamazaki, Tsutomu
AU - Furumoto, Tomoo
AU - Kario, Kazuomi
AU - Inoue, Teruo
AU - Koba, Shinji
AU - Watanabe, Kentaro
AU - Takemoto, Yasuhiko
AU - Hano, Takuzo
AU - Sata, Masataka
AU - Ishibashi, Yutaka
AU - Node, Koichi
AU - Maemura, Koji
AU - Ohya, Yusuke
AU - Furukawa, Taiji
AU - Itoh, Hiroshi
AU - Yamashina, Akira
PY - 2012
Y1 - 2012
N2 - Flow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulsewave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus. In total, we estimate that approximately 4000 Japanese subjects in 3 different study groups will eventually be enrolled in this prospective observational investigation. We anticipate that the present study will provide important evidence for the usefulness of FMD measurement in the risk stratification for cardiovascular disease.
AB - Flow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulsewave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus. In total, we estimate that approximately 4000 Japanese subjects in 3 different study groups will eventually be enrolled in this prospective observational investigation. We anticipate that the present study will provide important evidence for the usefulness of FMD measurement in the risk stratification for cardiovascular disease.
KW - Carotid atherosclerosis
KW - Coronary artery disease
KW - Endothelium
KW - Flow-mediated vasodilatation
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=84863470789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863470789&partnerID=8YFLogxK
U2 - 10.1536/ihj.53.170
DO - 10.1536/ihj.53.170
M3 - Article
VL - 53
SP - 170
EP - 175
JO - International Heart Journal
JF - International Heart Journal
SN - 1349-2365
IS - 3
ER -