A multicenter observational study on the clinicopathological features of gastric cancer in young patients

Yoshiyasu Kono, Hiromitsu Kanzaki, Takao Tsuzuki, Masahiro Takatani, Junichirou Nasu, Daisuke Kawai, Ryuta Takenaka, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Toshiyoshi Fujiwara, Hiroyuki Okada

Research output: Contribution to journalArticle

Abstract

Background: The details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients. Methods: From January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Their clinical characteristics and prognosis were evaluated. Results: The total number of patients was 72. The median age was 36 years, and the ratio of males to females was 1:1. The dominant histological type was undifferentiated type (66/72, 92%). Helicobacter pylori (H. pylori) was positive in 81% (54/67). Although there were some asymptomatic patients in stages I–III, all stage IV patients had some clinical symptoms at the diagnosis. The percentage of stage IV was significantly higher in patients in their 20s than in those in their 30s (75% vs. 25%, P < 0.001). The Kaplan–Meier method showed that the overall survival of patients in their 20s was significantly lower than that of patients in their 30s (P = 0.037). Conclusions: A high rate of H. pylori infection was revealed in young gastric cancer patients. The patients in their 20s had a worse prognosis than those in their 30s. We should consider examining the H. pylori infection status for young patients as well as older patients to identify high-risk populations.

Original languageEnglish
JournalJournal of Gastroenterology
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Multicenter Studies
Stomach Neoplasms
Observational Studies
Helicobacter pylori
Helicobacter Infections

Keywords

  • Gastric cancer
  • Helicobacter pylori
  • Young patient

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A multicenter observational study on the clinicopathological features of gastric cancer in young patients. / Kono, Yoshiyasu; Kanzaki, Hiromitsu; Tsuzuki, Takao; Takatani, Masahiro; Nasu, Junichirou; Kawai, Daisuke; Takenaka, Ryuta; Tanaka, Takehiro; Iwamuro, Masaya; Kawano, Seiji; Kawahara, Yoshiro; Fujiwara, Toshiyoshi; Okada, Hiroyuki.

In: Journal of Gastroenterology, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Tsuzuki, Takao

AU - Takatani, Masahiro

AU - Nasu, Junichirou

AU - Kawai, Daisuke

AU - Takenaka, Ryuta

AU - Tanaka, Takehiro

AU - Iwamuro, Masaya

AU - Kawano, Seiji

AU - Kawahara, Yoshiro

AU - Fujiwara, Toshiyoshi

AU - Okada, Hiroyuki

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