A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction

Masashi Ishihara, Hiroaki Ikesue, Hisashi Matsunaga, Katsuya Suemaru, Kiyoyuki Kitaichi, Kimitaka Suetsugu, Ryozo Oishi, Toshiaki Sendo, Hiroaki Araki, Yoshinori Itoh

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objectives: The aim of this study was to evaluate the effectiveness of prophylactic treatment with laxatives and antiemetics on the incidence of gastrointestinal adverse reactions such as constipation, nausea and vomiting in cancer patients who received oral opioid analgesics for the first time. Methods: A multi-institutional retrospective study was carried out, in which 619 eligible hospitalized patients receiving oral opioid analgesics for cancer pain were enrolled from 35 medical institutions. The primary endpoint was the incidence of opioid-induced side effects in patients receiving prophylactic medication. Odds ratios of the incidence of adverse reactions in the absence or presence of premedication obtained from several institutions were subjected to a meta-analysis. Results: Among 619 patients, the incidence of constipation was significantly lower in patients receiving laxatives, including magnesium oxide, as premedication than in those without them (34% vs. 55%, odds ratio=0.432, 95% confidence interval=0.300-0.622, P

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalClinical Journal of Pain
Volume28
Issue number5
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Opioid Analgesics
Laxatives
Premedication
Incidence
Constipation
Odds Ratio
Magnesium Oxide
Antiemetics
Nausea
Vomiting
Meta-Analysis
Retrospective Studies
Confidence Intervals
Neoplasms

Keywords

  • antiemetics
  • constipation
  • laxatives
  • multi-institutional study
  • nausea and vomiting
  • opioid analgesic
  • prophylaxis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction. / Ishihara, Masashi; Ikesue, Hiroaki; Matsunaga, Hisashi; Suemaru, Katsuya; Kitaichi, Kiyoyuki; Suetsugu, Kimitaka; Oishi, Ryozo; Sendo, Toshiaki; Araki, Hiroaki; Itoh, Yoshinori.

In: Clinical Journal of Pain, Vol. 28, No. 5, 06.2012, p. 373-381.

Research output: Contribution to journalArticle

Ishihara, M, Ikesue, H, Matsunaga, H, Suemaru, K, Kitaichi, K, Suetsugu, K, Oishi, R, Sendo, T, Araki, H & Itoh, Y 2012, 'A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction', Clinical Journal of Pain, vol. 28, no. 5, pp. 373-381. https://doi.org/10.1097/AJP.0b013e318237d626
Ishihara, Masashi ; Ikesue, Hiroaki ; Matsunaga, Hisashi ; Suemaru, Katsuya ; Kitaichi, Kiyoyuki ; Suetsugu, Kimitaka ; Oishi, Ryozo ; Sendo, Toshiaki ; Araki, Hiroaki ; Itoh, Yoshinori. / A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction. In: Clinical Journal of Pain. 2012 ; Vol. 28, No. 5. pp. 373-381.
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