A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta

M. Noda; T. Asai; Toshinori Shimanouchi; K. Yamashita; H. Umakoshi; M. Okuyama; R. Kuboi

doi:10.1016/j.proche.2009.07.267

A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta

M. Noda, T. Asai, Toshinori Shimanouchi, K. Yamashita, H. Umakoshi, M. Okuyama, R. Kuboi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

Original language	English
Title of host publication	Procedia Chemistry
Pages	1071-1074
Number of pages	4
Volume	1
Edition	1
DOIs	https://doi.org/10.1016/j.proche.2009.07.267
Publication status	Published - Sep 2009
Externally published	Yes
Event	Eurosensors 23rd Conference - Lausanne, Switzerland Duration: Sep 6 2009 → Sep 9 2009

Other

Other	Eurosensors 23rd Conference
Country	Switzerland
City	Lausanne
Period	9/6/09 → 9/9/09

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Keywords

Alzheimer's disease
Amyloid beta
Bio-thermochemical
Liposome
Microbolometer

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

Cite this

Noda, M., Asai, T., Shimanouchi, T., Yamashita, K., Umakoshi, H., Okuyama, M., & Kuboi, R. (2009). A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta. In Procedia Chemistry (1 ed., Vol. 1, pp. 1071-1074) https://doi.org/10.1016/j.proche.2009.07.267

A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta. / Noda, M.; Asai, T.; Shimanouchi, Toshinori; Yamashita, K.; Umakoshi, H.; Okuyama, M.; Kuboi, R.

Procedia Chemistry. Vol. 1 1. ed. 2009. p. 1071-1074.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Noda, M, Asai, T, Shimanouchi, T, Yamashita, K, Umakoshi, H, Okuyama, M & Kuboi, R 2009, A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta. in Procedia Chemistry. 1 edn, vol. 1, pp. 1071-1074, Eurosensors 23rd Conference, Lausanne, Switzerland, 9/6/09. https://doi.org/10.1016/j.proche.2009.07.267

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abstract = "Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.",

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10.1016/j.proche.2009.07.267