Abstract
Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
| Original language | English |
|---|---|
| Title of host publication | Procedia Chemistry |
| Pages | 1071-1074 |
| Number of pages | 4 |
| Volume | 1 |
| Edition | 1 |
| DOIs | |
| Publication status | Published - Sep 2009 |
| Externally published | Yes |
| Event | Eurosensors 23rd Conference - Lausanne, Switzerland Duration: Sep 6 2009 → Sep 9 2009 |
Other
| Other | Eurosensors 23rd Conference |
|---|---|
| Country | Switzerland |
| City | Lausanne |
| Period | 9/6/09 → 9/9/09 |
Fingerprint
Keywords
- Alzheimer's disease
- Amyloid beta
- Bio-thermochemical
- Liposome
- Microbolometer
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta. / Noda, M.; Asai, T.; Shimanouchi, Toshinori; Yamashita, K.; Umakoshi, H.; Okuyama, M.; Kuboi, R.
Procedia Chemistry. Vol. 1 1. ed. 2009. p. 1071-1074.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta
AU - Noda, M.
AU - Asai, T.
AU - Shimanouchi, Toshinori
AU - Yamashita, K.
AU - Umakoshi, H.
AU - Okuyama, M.
AU - Kuboi, R.
PY - 2009/9
Y1 - 2009/9
N2 - Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
AB - Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
KW - Alzheimer's disease
KW - Amyloid beta
KW - Bio-thermochemical
KW - Liposome
KW - Microbolometer
UR - http://www.scopus.com/inward/record.url?scp=71549170485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71549170485&partnerID=8YFLogxK
U2 - 10.1016/j.proche.2009.07.267
DO - 10.1016/j.proche.2009.07.267
M3 - Conference contribution
AN - SCOPUS:71549170485
VL - 1
SP - 1071
EP - 1074
BT - Procedia Chemistry
ER -