A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta

M. Noda; T. Asai; T. Shimanouchi; K. Yamashita; H. Umakoshi; M. Okuyama; R. Kuboi

doi:10.1016/j.proche.2009.07.267

A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta

M. Noda, T. Asai, T. Shimanouchi, K. Yamashita, H. Umakoshi, M. Okuyama, R. Kuboi

Research output: Contribution to journal › Conference article › peer-review

1 Citation (Scopus)

Abstract

Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

Original language	English
Pages (from-to)	1071-1074
Number of pages	4
Journal	Procedia Chemistry
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.proche.2009.07.267
Publication status	Published - Sep 2009
Externally published	Yes
Event	Eurosensors 23rd Conference - Lausanne, Switzerland Duration: Sep 6 2009 → Sep 9 2009

Keywords

Alzheimer's disease
Amyloid beta
Bio-thermochemical
Liposome
Microbolometer

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta. / Noda, M.; Asai, T.; Shimanouchi, T.; Yamashita, K.; Umakoshi, H.; Okuyama, M.; Kuboi, R.

In: Procedia Chemistry, Vol. 1, No. 1, 09.2009, p. 1071-1074.

Research output: Contribution to journal › Conference article › peer-review

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title = "A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta",

abstract = "Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.",

keywords = "Alzheimer's disease, Amyloid beta, Bio-thermochemical, Liposome, Microbolometer",

author = "M. Noda and T. Asai and T. Shimanouchi and K. Yamashita and H. Umakoshi and M. Okuyama and R. Kuboi",

note = "Funding Information: This research was supported in part by Grants-in-Aid for Scientific Research (No. 19360162, 21246121, 20760539) from the Japan Society for the Promotion of Science. It was partly supported by the Core University Program between JSPS and VAST.; Eurosensors 23rd Conference ; Conference date: 06-09-2009 Through 09-09-2009",

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AU - Noda, M.

AU - Asai, T.

AU - Shimanouchi, T.

AU - Yamashita, K.

AU - Umakoshi, H.

AU - Okuyama, M.

AU - Kuboi, R.

N1 - Funding Information: This research was supported in part by Grants-in-Aid for Scientific Research (No. 19360162, 21246121, 20760539) from the Japan Society for the Promotion of Science. It was partly supported by the Core University Program between JSPS and VAST.

PY - 2009/9

Y1 - 2009/9

N2 - Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

AB - Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

KW - Alzheimer's disease

KW - Amyloid beta

KW - Bio-thermochemical

KW - Liposome

KW - Microbolometer

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ER -

A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta

Abstract

Keywords

ASJC Scopus subject areas

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