A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta

M. Noda, T. Asai, T. Shimanouchi, K. Yamashita, H. Umakoshi, M. Okuyama, R. Kuboi

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalProcedia Chemistry
Volume1
Issue number1
DOIs
Publication statusPublished - Sep 1 2009
Externally publishedYes
EventEurosensors 23rd Conference - Lausanne, Switzerland
Duration: Sep 6 2009Sep 9 2009

Keywords

  • Alzheimer's disease
  • Amyloid beta
  • Bio-thermochemical
  • Liposome
  • Microbolometer

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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