Abstract
Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.
| Original language | English |
|---|---|
| Pages (from-to) | 1071-1074 |
| Number of pages | 4 |
| Journal | Procedia Chemistry |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 1 2009 |
| Externally published | Yes |
| Event | Eurosensors 23rd Conference - Lausanne, Switzerland Duration: Sep 6 2009 → Sep 9 2009 |
Keywords
- Alzheimer's disease
- Amyloid beta
- Bio-thermochemical
- Liposome
- Microbolometer
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
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Cite this
Noda, M., Asai, T., Shimanouchi, T., Yamashita, K., Umakoshi, H., Okuyama, M., & Kuboi, R. (2009). A Microbolometer of Bio-Thermochemical Sensor Immobilized Liposome for Detection of Causative Protein of Alzheimer's Disease, Amyloid Beta. Procedia Chemistry, 1(1), 1071-1074. https://doi.org/10.1016/j.proche.2009.07.267