A metal-, oxidant-, and fluorous solvent-free synthesis of α-indolylketones enabled by an umpolung strategy

Takumi Abe, Seiya Hirao, Toshiki Yamashiro

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Enamines undergo α-indolization with ammonium salts in the presence of Et3N to form α-indolylketones. This is the first example of transition metal-, oxidant-, and fluorous solvent-free α-indolization of ketones. Key to the success of this convenient protocol was the use ofin situgenerated electrophilic indole species, as well as the use of enamines as a ketone enolate equivalent.

Original languageEnglish
Pages (from-to)10183-10186
Number of pages4
JournalChemical Communications
Volume56
Issue number70
DOIs
Publication statusPublished - Sep 11 2020
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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