A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

Kazumasa Aoki; Hideharu Maruta; Fumiaki Uchiumi; Tsutomu Hatano; Takashi Yoshida; Sei Ichi Tanuma

doi:10.1006/bbrc.1995.1665

A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

Kazumasa Aoki, Hideharu Maruta, Fumiaki Uchiumi, Tsutomu Hatano, Takashi Yoshida, Sei Ichi Tanuma

Research output: Contribution to journal › Article

42 Citations (Scopus)

Abstract

Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.

Original language	English
Pages (from-to)	329-337
Number of pages	9
Journal	Biochemical and Biophysical Research Communications
Volume	210
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1995.1665
Publication status	Published - May 16 1995
Externally published	Yes

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ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Cite this

Aoki, K., Maruta, H., Uchiumi, F., Hatano, T., Yoshida, T., & Tanuma, S. I. (1995). A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase. Biochemical and Biophysical Research Communications, 210(2), 329-337. https://doi.org/10.1006/bbrc.1995.1665

A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase. / Aoki, Kazumasa; Maruta, Hideharu; Uchiumi, Fumiaki; Hatano, Tsutomu; Yoshida, Takashi; Tanuma, Sei Ichi.

In: Biochemical and Biophysical Research Communications, Vol. 210, No. 2, 16.05.1995, p. 329-337.

Research output: Contribution to journal › Article

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10.1006/bbrc.1995.1665