A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

Kazumasa Aoki; Hideharu Maruta; Fumiaki Uchiumi; Tsutomu Hatano; Takashi Yoshida; Sei Ichi Tanuma

doi:10.1006/bbrc.1995.1665

A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

Kazumasa Aoki, Hideharu Maruta, Fumiaki Uchiumi, Tsutomu Hatano, Takashi Yoshida, Sei Ichi Tanuma

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.

Original language	English
Pages (from-to)	329-337
Number of pages	9
Journal	Biochemical and Biophysical Research Communications
Volume	210
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1995.1665
Publication status	Published - May 16 1995
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1006/bbrc.1995.1665

Fingerprint Dive into the research topics of 'A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase'. Together they form a unique fingerprint.

Cite this

A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase. / Aoki, Kazumasa; Maruta, Hideharu; Uchiumi, Fumiaki; Hatano, Tsutomu; Yoshida, Takashi; Tanuma, Sei Ichi.

In: Biochemical and Biophysical Research Communications, Vol. 210, No. 2, 16.05.1995, p. 329-337.

Research output: Contribution to journal › Article › peer-review

@article{1231924a9d8144cab01a4eda04aad503,

title = "A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase",

abstract = "Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.",

author = "Kazumasa Aoki and Hideharu Maruta and Fumiaki Uchiumi and Tsutomu Hatano and Takashi Yoshida and Tanuma, {Sei Ichi}",

year = "1995",

month = may,

day = "16",

doi = "10.1006/bbrc.1995.1665",

language = "English",

volume = "210",

pages = "329--337",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

AU - Aoki, Kazumasa

AU - Maruta, Hideharu

AU - Uchiumi, Fumiaki

AU - Hatano, Tsutomu

AU - Yoshida, Takashi

AU - Tanuma, Sei Ichi

PY - 1995/5/16

Y1 - 1995/5/16

N2 - Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.

AB - Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.

UR - http://www.scopus.com/inward/record.url?scp=0029057697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029057697&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1995.1665

DO - 10.1006/bbrc.1995.1665

M3 - Article

C2 - 7755607

AN - SCOPUS:0029057697

VL - 210

SP - 329

EP - 337

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -