TY - JOUR
T1 - A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase
AU - Aoki, Kazumasa
AU - Maruta, Hideharu
AU - Uchiumi, Fumiaki
AU - Hatano, Tsutomu
AU - Yoshida, Takashi
AU - Tanuma, Sei Ichi
PY - 1995/5/16
Y1 - 1995/5/16
N2 - Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.
AB - Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.
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U2 - 10.1006/bbrc.1995.1665
DO - 10.1006/bbrc.1995.1665
M3 - Article
C2 - 7755607
AN - SCOPUS:0029057697
VL - 210
SP - 329
EP - 337
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -