A macrocircular ellagitannin, oenothein b, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

Kazumasa Aoki, Hideharu Maruta, Fumiaki Uchiumi, Tsutomu Hatano, Takashi Yoshida, Sei Ichi Tanuma

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume210
Issue number2
DOIs
Publication statusPublished - May 16 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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