A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia

Mikiya Nakatsuka, Masayo Takata, Katsuhiko Tada, Kazuo Asagiri, Toshihiro Habara, Soichi Noguchi, Takafumi Kudo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective. To determine the effects of long-term transdermal administration (range, 4-30 days; mean ± SD, 11.1 ± 7.2 days) of isosorbide dinitrate, a nitric oxide donor, in preeclamptic women. Methods. We studied uterine and fetoplacental circulation of 12 preeclamptic women with oligohydramnios and an elevated pulsatility index in the uterine arteries. Results. Transdermal isosorbide dinitrate significantly suppressed the blood pressure of patients. Pulsed Doppler ultrasonography revealed that the average pulsatility index in the uterine arteries was significantly reduced by treatment with isosorbide dinitrate (P <.003). The average pulsatility index in the umbilical artery was also significantly reduced (P <.004). Furthermore, the size of the amniotic fluid pocket increased approximately 4-fold by treatment with isosorbide dinitrate. Conclusions. Long-term transdermal administration of isosorbide dinitrate improves fetoplacental circulation and may be effective therapy for avoiding maternal hypertension and oligohydramnios in some preeclamptic women.

Original languageEnglish
Pages (from-to)831-836
Number of pages6
JournalJournal of Ultrasound in Medicine
Volume21
Issue number8
Publication statusPublished - 2002

Fingerprint

Placental Circulation
dinitrates
Isosorbide Dinitrate
Nitric Oxide Donors
nitric oxide
Pre-Eclampsia
arteries
Cutaneous Administration
Oligohydramnios
Uterine Artery
Doppler Pulsed Ultrasonography
hypertension
blood pressure
Umbilical Arteries
Amniotic Fluid
therapy
Therapeutics
Mothers
Blood Pressure
Hypertension

Keywords

  • Nitric oxide
  • Oligohydramnios
  • Preeclampsia
  • Pregnancy
  • Pulsed Doppler ultrasonography
  • Uterine arteries

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Acoustics and Ultrasonics
  • Radiological and Ultrasound Technology

Cite this

Nakatsuka, M., Takata, M., Tada, K., Asagiri, K., Habara, T., Noguchi, S., & Kudo, T. (2002). A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia. Journal of Ultrasound in Medicine, 21(8), 831-836.

A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia. / Nakatsuka, Mikiya; Takata, Masayo; Tada, Katsuhiko; Asagiri, Kazuo; Habara, Toshihiro; Noguchi, Soichi; Kudo, Takafumi.

In: Journal of Ultrasound in Medicine, Vol. 21, No. 8, 2002, p. 831-836.

Research output: Contribution to journalArticle

Nakatsuka, M, Takata, M, Tada, K, Asagiri, K, Habara, T, Noguchi, S & Kudo, T 2002, 'A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia', Journal of Ultrasound in Medicine, vol. 21, no. 8, pp. 831-836.
Nakatsuka, Mikiya ; Takata, Masayo ; Tada, Katsuhiko ; Asagiri, Kazuo ; Habara, Toshihiro ; Noguchi, Soichi ; Kudo, Takafumi. / A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia. In: Journal of Ultrasound in Medicine. 2002 ; Vol. 21, No. 8. pp. 831-836.
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