A Long-term survivor after congenital acute myeloid leukemia with t(8 ; 16)(p11 ; p13)

Takae Hanada, Kiichiro Kanamitsu, Kosuke Chayama, Takako Miyamura, Yui Kanazawa, Michiko Muraoka, Kana Washio, Masahide Imada, Misao Kageyama, Akihito Takeuchi, Kei Tamai, Megumi Oda, Akira Shimada

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8; 16) (pll; pl3) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ CBP in the pediatric population might show better prognoses.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalActa medica Okayama
Volume70
Issue number1
Publication statusPublished - 2016

Keywords

  • AML
  • Congenital leukemia
  • MOZ-CBP
  • t(8 ; 16)(pll ;pl3)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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