A Long-term survivor after congenital acute myeloid leukemia with t(8 ; 16)(p11 ; p13)

Takae Hanada; Kiichiro Kanemitsu; Kosuke Chayama; Takako Miyamura; Yui Kanazawa; Michiko Muraoka; Kana Washio; Masahide Imada; Misao Kageyama; Akihito Takeuchi; Kei Tamai; Megumi Oda; Akira Shimada

A Long-term survivor after congenital acute myeloid leukemia with t(8 ; 16)(p11 ; p13)

Takae Hanada, Kiichiro Kanemitsu, Kosuke Chayama, Takako Miyamura, Yui Kanazawa, Michiko Muraoka, Kana Washio, Masahide Imada, Misao Kageyama, Akihito Takeuchi, Kei Tamai, Megumi Oda, Akira Shimada

University Hospital

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8; 16) (pll; pl3) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ CBP in the pediatric population might show better prognoses.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Acta medica Okayama
Volume	70
Issue number	1
Publication status	Published - 2016

Keywords

AML
Congenital leukemia
MOZ-CBP
t(8 ; 16)(pll ;pl3)

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8; 16) (pll; pl3) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ CBP in the pediatric population might show better prognoses.",

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T1 - A Long-term survivor after congenital acute myeloid leukemia with t(8 ; 16)(p11 ; p13)

AU - Hanada, Takae

AU - Kanemitsu, Kiichiro

AU - Chayama, Kosuke

AU - Miyamura, Takako

AU - Kanazawa, Yui

AU - Muraoka, Michiko

AU - Washio, Kana

AU - Imada, Masahide

AU - Kageyama, Misao

AU - Takeuchi, Akihito

AU - Tamai, Kei

AU - Oda, Megumi

AU - Shimada, Akira

PY - 2016

Y1 - 2016

N2 - The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8; 16) (pll; pl3) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ CBP in the pediatric population might show better prognoses.

AB - The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8; 16) (pll; pl3) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ CBP in the pediatric population might show better prognoses.

KW - AML

KW - Congenital leukemia

KW - MOZ-CBP

KW - t(8 ; 16)(pll ;pl3)

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A Long-term survivor after congenital acute myeloid leukemia with t(8 ; 16)(p11 ; p13)

Abstract

Keywords

ASJC Scopus subject areas

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