A kinetic study of carbohydrate metabolism in pregnancy. A glucose turn over following one shot intravenous injection

K. Sekiba, Yoshihiro Takeda, T. Kudo, N. Akiyama, Y. Ishikawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In an attempt to evaluate a clinical use of maternal glucose administration during pregnancy and parturition, changes in glucose space and its turnover rate in pregnancy were determined in pregnant mice. Specific activities in whole blood obtained by serial sampling followed a single intravenous injection of Glucose-U-C 14 were analyzed by three compartment sequential model (S. M. Skinner et al., 1958). A blood glucose pool size was increased approximately 30% of control, while a total glucose pool size was more enlarged in pregnancy. A half time in the first compartment was accelerated in pregnancy, while those in the second and the third compartment were delayed. A turnover rate in the first compartment was also accelerated in pregnancy; however, a total turnover rate and an irreversible disposal were decreased to 4/5th of the control. Because of a large increase of glucose pool size and tissue utilization in pregnancy, hypertonic glucose of 40% may be more effective than 20% glucose to the correction of fetal glucose environment. Since a peak value in the third compartment was observed at 14 minutes following maternal administration, it is recommended that maternal administration should be done at least 15 minutes before delivery.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalActa Obstetrica et Gynaecologica Japonica
Volume23
Issue number3
Publication statusPublished - 1976

Fingerprint

Carbohydrate Metabolism
Intravenous Injections
Glucose
Pregnancy
Mothers
Pregnancy Rate
Blood Glucose
Parturition

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

A kinetic study of carbohydrate metabolism in pregnancy. A glucose turn over following one shot intravenous injection. / Sekiba, K.; Takeda, Yoshihiro; Kudo, T.; Akiyama, N.; Ishikawa, Y.

In: Acta Obstetrica et Gynaecologica Japonica, Vol. 23, No. 3, 1976, p. 195-200.

Research output: Contribution to journalArticle

@article{69dc5f6f16cd48fdacf0179b3eb4fe09,
title = "A kinetic study of carbohydrate metabolism in pregnancy. A glucose turn over following one shot intravenous injection",
abstract = "In an attempt to evaluate a clinical use of maternal glucose administration during pregnancy and parturition, changes in glucose space and its turnover rate in pregnancy were determined in pregnant mice. Specific activities in whole blood obtained by serial sampling followed a single intravenous injection of Glucose-U-C 14 were analyzed by three compartment sequential model (S. M. Skinner et al., 1958). A blood glucose pool size was increased approximately 30{\%} of control, while a total glucose pool size was more enlarged in pregnancy. A half time in the first compartment was accelerated in pregnancy, while those in the second and the third compartment were delayed. A turnover rate in the first compartment was also accelerated in pregnancy; however, a total turnover rate and an irreversible disposal were decreased to 4/5th of the control. Because of a large increase of glucose pool size and tissue utilization in pregnancy, hypertonic glucose of 40{\%} may be more effective than 20{\%} glucose to the correction of fetal glucose environment. Since a peak value in the third compartment was observed at 14 minutes following maternal administration, it is recommended that maternal administration should be done at least 15 minutes before delivery.",
author = "K. Sekiba and Yoshihiro Takeda and T. Kudo and N. Akiyama and Y. Ishikawa",
year = "1976",
language = "English",
volume = "23",
pages = "195--200",
journal = "Nippon Sanka Fujinka Gakkai zasshi",
issn = "0300-9165",
publisher = "Japanese Obstetrical And Gynecological Society",
number = "3",

}

TY - JOUR

T1 - A kinetic study of carbohydrate metabolism in pregnancy. A glucose turn over following one shot intravenous injection

AU - Sekiba, K.

AU - Takeda, Yoshihiro

AU - Kudo, T.

AU - Akiyama, N.

AU - Ishikawa, Y.

PY - 1976

Y1 - 1976

N2 - In an attempt to evaluate a clinical use of maternal glucose administration during pregnancy and parturition, changes in glucose space and its turnover rate in pregnancy were determined in pregnant mice. Specific activities in whole blood obtained by serial sampling followed a single intravenous injection of Glucose-U-C 14 were analyzed by three compartment sequential model (S. M. Skinner et al., 1958). A blood glucose pool size was increased approximately 30% of control, while a total glucose pool size was more enlarged in pregnancy. A half time in the first compartment was accelerated in pregnancy, while those in the second and the third compartment were delayed. A turnover rate in the first compartment was also accelerated in pregnancy; however, a total turnover rate and an irreversible disposal were decreased to 4/5th of the control. Because of a large increase of glucose pool size and tissue utilization in pregnancy, hypertonic glucose of 40% may be more effective than 20% glucose to the correction of fetal glucose environment. Since a peak value in the third compartment was observed at 14 minutes following maternal administration, it is recommended that maternal administration should be done at least 15 minutes before delivery.

AB - In an attempt to evaluate a clinical use of maternal glucose administration during pregnancy and parturition, changes in glucose space and its turnover rate in pregnancy were determined in pregnant mice. Specific activities in whole blood obtained by serial sampling followed a single intravenous injection of Glucose-U-C 14 were analyzed by three compartment sequential model (S. M. Skinner et al., 1958). A blood glucose pool size was increased approximately 30% of control, while a total glucose pool size was more enlarged in pregnancy. A half time in the first compartment was accelerated in pregnancy, while those in the second and the third compartment were delayed. A turnover rate in the first compartment was also accelerated in pregnancy; however, a total turnover rate and an irreversible disposal were decreased to 4/5th of the control. Because of a large increase of glucose pool size and tissue utilization in pregnancy, hypertonic glucose of 40% may be more effective than 20% glucose to the correction of fetal glucose environment. Since a peak value in the third compartment was observed at 14 minutes following maternal administration, it is recommended that maternal administration should be done at least 15 minutes before delivery.

UR - http://www.scopus.com/inward/record.url?scp=0017045543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017045543&partnerID=8YFLogxK

M3 - Article

C2 - 1026048

AN - SCOPUS:0017045543

VL - 23

SP - 195

EP - 200

JO - Nippon Sanka Fujinka Gakkai zasshi

JF - Nippon Sanka Fujinka Gakkai zasshi

SN - 0300-9165

IS - 3

ER -