A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients

Ikuo Sekine, Yasushi Shintani, Takehito Shukuya, Koichi Takayama, Akira Inoue, Isamu Okamoto, Katsuyuki Kiura, Kazuhisa Takahashi, Hirotoshi Dosaka-Akita, Yuichi Takiguchi, Etsuo Miyaoka, Meinoshin Okumura, Ichiro Yoshino

Research output: Contribution to journalArticle

Abstract

This study provides the benchmark statistics on medically treated patients with non–small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) in Japan. Demographic background, treatment, and prognosis were obtained from patients with lung cancer pathologically diagnosed in 2012, who received nonsurgical treatment. Descriptive statistics and their associations with survival were analyzed. In total, 12 320 patients were registered from 314 institutions in Japan. The median age was 70 years, and 73% of the patients were male. The number (%) of stages I, II, III, and IV diseases were 468 (3.8%), 421 (3.4%), 3260 (26.5%), and 8171 (66.3%), respectively. NSCLC and SCLC accounted for 9872 (80.1%) and 2353 (19.1%) patients, respectively. Thoracic radiotherapy-based therapy, chemotherapy, and palliative care alone were administered to 2572 (20.9%), 7790 (63.2%), and 1952 (15.8%) patients, respectively. Clinical TNM stage was one of the strongest prognostic factors with the 3-year survival rates of 62.9%, 47.3%, 40.0%, 27.8%, 37.5%, 26.5%, and 18.2% for stages IA, IB, IIA, IIB, IIIA, IIIB, and IV, respectively. Among 6158 patients with NSCLC treated with chemotherapy, the 3-year survival rate was 33.4% in patients receiving epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) at some point in their clinical course, whereas it was 17.4% in patients who did not. The 3-year survival rate of SCLC was only 15.9%. In conclusion, approximately two-thirds of the patients were diagnosed as stage IV at the initial diagnosis. Use of EGFR-TKIs significantly improved the survival of patients with NSCLC.

Original languageEnglish
Pages (from-to)1685-1691
Number of pages7
JournalCancer Science
Volume111
Issue number5
DOIs
Publication statusPublished - May 1 2020
Externally publishedYes

Keywords

  • TNM stage
  • epidermal growth factor receptor
  • non–small cell lung cancer
  • small cell lung cancer
  • tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Sekine, I., Shintani, Y., Shukuya, T., Takayama, K., Inoue, A., Okamoto, I., Kiura, K., Takahashi, K., Dosaka-Akita, H., Takiguchi, Y., Miyaoka, E., Okumura, M., & Yoshino, I. (2020). A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients. Cancer Science, 111(5), 1685-1691. https://doi.org/10.1111/cas.14368