A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings

Koh Tadokoro; Yasuyuki Ohta; Kota Sato; Takahiro Maeki; Ryo Sasaki; Yoshiaki Takahashi; Jingwei Shang; Mami Takemoto; Nozomi Hishikawa; Toru Yamashita; Chang Kweng Lim; Shigeru Tajima; Koji Abe

doi:10.2169/internalmedicine.0337-17

A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings

Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Takahiro Maeki, Ryo Sasaki, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Chang Kweng Lim, Shigeru Tajima, Koji Abe

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using¹²³I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (¹²³I-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.

Original language	English
Pages (from-to)	2243-2246
Number of pages	4
Journal	Internal Medicine
Volume	57
Issue number	15
DOIs	https://doi.org/10.2169/internalmedicine.0337-17
Publication status	Published - 2018

Keywords

DAT
I-FP-CIT
Japanese encephalitis
Parkinsonism

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.0337-17

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Tadokoro, K., Ohta, Y., Sato, K., Maeki, T., Sasaki, R., Takahashi, Y., Shang, J., Takemoto, M., Hishikawa, N., Yamashita, T., Lim, C. K., Tajima, S., & Abe, K. (2018). A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings. Internal Medicine, 57(15), 2243-2246. https://doi.org/10.2169/internalmedicine.0337-17

A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings. / Tadokoro, Koh; Ohta, Yasuyuki; Sato, Kota; Maeki, Takahiro; Sasaki, Ryo; Takahashi, Yoshiaki; Shang, Jingwei; Takemoto, Mami ; Hishikawa, Nozomi ; Yamashita, Toru; Lim, Chang Kweng; Tajima, Shigeru; Abe, Koji.

In: Internal Medicine, Vol. 57, No. 15, 2018, p. 2243-2246.

Research output: Contribution to journal › Article

Tadokoro, K, Ohta, Y, Sato, K, Maeki, T, Sasaki, R, Takahashi, Y, Shang, J, Takemoto, M , Hishikawa, N , Yamashita, T, Lim, CK, Tajima, S & Abe, K 2018, 'A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings', Internal Medicine, vol. 57, no. 15, pp. 2243-2246. https://doi.org/10.2169/internalmedicine.0337-17

Tadokoro, Koh ; Ohta, Yasuyuki ; Sato, Kota ; Maeki, Takahiro ; Sasaki, Ryo ; Takahashi, Yoshiaki ; Shang, Jingwei ; Takemoto, Mami ; Hishikawa, Nozomi ; Yamashita, Toru ; Lim, Chang Kweng ; Tajima, Shigeru ; Abe, Koji. / A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings. In: Internal Medicine. 2018 ; Vol. 57, No. 15. pp. 2243-2246.

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abstract = "Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.",

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AU - Tadokoro, Koh

AU - Ohta, Yasuyuki

AU - Sato, Kota

AU - Maeki, Takahiro

AU - Sasaki, Ryo

AU - Takahashi, Yoshiaki

AU - Shang, Jingwei

AU - Takemoto, Mami

AU - Hishikawa, Nozomi

AU - Yamashita, Toru

AU - Lim, Chang Kweng

AU - Tajima, Shigeru

AU - Abe, Koji

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AB - Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.

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