A Japanese encephalitis patient presenting with parkinsonism with corresponding laterality of magnetic resonance and dopamine transporter imaging findings

Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Takahiro Maeki, Ryo Sasaki, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Chang Kweng Lim, Shigeru Tajima, Koji Abe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.

Original languageEnglish
Pages (from-to)2243-2246
Number of pages4
JournalInternal Medicine
Volume57
Issue number15
DOIs
Publication statusPublished - 2018

Keywords

  • DAT
  • I-FP-CIT
  • Japanese encephalitis
  • Parkinsonism

ASJC Scopus subject areas

  • Internal Medicine

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