A genome-wide association study reveals a quantitative trait locus for age at first calving in delta/notch-like EGF repeat containing on chromosome 2 in Japanese Black cattle

Shinji Sasaki, Takayuki Ibi, Shogo Ikeda, Yoshikazu Sugimoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Age at first calving (AFC) is an important trait for achieving earlier reproductive performance in cattle. To identify quantitative trait loci for AFC in Japanese Black cattle, we conducted a genome-wide association study using 866 animals with extreme AFC values selected from a larger group of 52 009 animals. We identified single nucleotide polymorphisms (SNPs) on bovine chromosome 2 that were associated with AFC. These SNPs were located within 112.8-kbp intronic region of delta/notch-like EGF repeat containing (DNER) and proved to be in a state of high linkage disequilibrium. The association was replicated in an independent sample of 2963 animals. In the replicated population, the frequency of the reduced AFC allele (Q) was 0.463, and the allele accounts for 8% of the total genetic variance. The effect of allele substitution on AFC was a decrease of 11.54 days. The results suggest that the Q allele could serve as a useful marker in Japanese Black cattle to select animals with superior AFC performance.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalAnimal Genetics
Volume45
Issue number2
DOIs
Publication statusPublished - Apr 2014

Fingerprint

Wagyu
Chromosomes, Human, Pair 2
Quantitative Trait Loci
Genome-Wide Association Study
Epidermal Growth Factor
calving
quantitative trait loci
Alleles
chromosomes
cattle
Single Nucleotide Polymorphism
alleles
Linkage Disequilibrium
single nucleotide polymorphism
animals
linkage disequilibrium
genetic variance
genome-wide association study
reproductive performance
Population

Keywords

  • age at first calving (AFC)
  • delta/notch-like EGF repeat containing (DNER)
  • genome-wide association study (GWAS)

ASJC Scopus subject areas

  • Genetics
  • Animal Science and Zoology

Cite this

A genome-wide association study reveals a quantitative trait locus for age at first calving in delta/notch-like EGF repeat containing on chromosome 2 in Japanese Black cattle. / Sasaki, Shinji; Ibi, Takayuki; Ikeda, Shogo; Sugimoto, Yoshikazu.

In: Animal Genetics, Vol. 45, No. 2, 04.2014, p. 285-287.

Research output: Contribution to journalArticle

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