A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase

Tetsuo Kunieda, Eiji Kobayashi, Motokazu Tachibana, Hiroshi Ikadai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/lar x IS/lar)F1 x WKS/lar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes.

Original languageEnglish
Pages (from-to)43-45
Number of pages3
JournalExperimental Animals
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 1999

Keywords

  • Aox
  • Linkage map
  • Rat

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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