A Flexible Method for Covalent Double Functionalization of Graphene Oxide

Shi Guo, Yuta Nishina, Alberto Bianco, Cécilia Ménard-Moyon

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


A method for the double functionalization of graphene oxide (GO) under mild alkaline conditions has been developed. Two functional groups were covalently linked to GO in two steps: the first group was attached by an epoxide ring-opening reaction and the second, bearing an amine function, was covalently conjugated to benzoquinone attached to the GO. The doubly functionalized GO was characterized by several techniques, confirming the sequential covalent modification of the GO surface with two different functional groups. This method is straightforward and the reaction conditions are mild, allowing preservation of the structure and properties of GO. This strategy could be exploited to prepare multifunctional GO conjugates with potential applications in many fields ranging from materials science to biomedicine.

Original languageEnglish
Pages (from-to)1542-1547
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number4
Publication statusPublished - Jan 20 2020


  • Michael addition
  • graphene
  • materials science
  • small ring systems
  • surface chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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