A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress

Yoshimasa Nakamura, Toshihiko Osawa

Research output: Contribution to journalArticle

Abstract

We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB®), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.

Original languageEnglish
Pages (from-to)373-375
Number of pages3
JournalFood Science and Technology Research
Volume11
Issue number4
DOIs
Publication statusPublished - Dec 2005

Fingerprint

grain foods
Oxidative stress
fermented foods
Antioxidants
Carcinogens
Tumors
Skin
foods
Oxidative Stress
oxidative stress
antioxidants
Food
neoplasms
extracts
Dietary supplements
HL-60 Cells
mice
Phorbol Esters
Dietary Supplements
Hydrogen peroxide

Keywords

  • Antioxidant
  • Mouse skin
  • Oxidative stress
  • Phorbol ester

ASJC Scopus subject areas

  • Food Science

Cite this

A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress. / Nakamura, Yoshimasa; Osawa, Toshihiko.

In: Food Science and Technology Research, Vol. 11, No. 4, 12.2005, p. 373-375.

Research output: Contribution to journalArticle

@article{a73d98a116c047f79663a1a1ef2b162d,
title = "A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress",
abstract = "We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB{\circledR}), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.",
keywords = "Antioxidant, Mouse skin, Oxidative stress, Phorbol ester",
author = "Yoshimasa Nakamura and Toshihiko Osawa",
year = "2005",
month = "12",
doi = "10.3136/fstr.11.373",
language = "English",
volume = "11",
pages = "373--375",
journal = "Food Science and Technology Research",
issn = "1344-6606",
publisher = "Japanese Society for Food Science and Technology",
number = "4",

}

TY - JOUR

T1 - A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress

AU - Nakamura, Yoshimasa

AU - Osawa, Toshihiko

PY - 2005/12

Y1 - 2005/12

N2 - We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB®), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.

AB - We demonstrated that a dietary supplement, Antioxidant Biofactor (AOB®), a fermented grain food, inhibits phorbol ester (TPA)-induced inflammatory responses. Pretreatment of mouse skin with ethyl acetate extract of AOB (0.5 mg) significantly attenuated the hydrogen peroxide level in mouse skin without inhibition of edema formation. Also, exposure of AOB extract to differentiated HL-60 cells resulted in dose-dependent inhibition of TPA-induced Superoxide generation, which was stronger than those of the raw materials of AOB. Our results suggest that AOB is effective for prevention of skin oxidative stress.

KW - Antioxidant

KW - Mouse skin

KW - Oxidative stress

KW - Phorbol ester

UR - http://www.scopus.com/inward/record.url?scp=37849185542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37849185542&partnerID=8YFLogxK

U2 - 10.3136/fstr.11.373

DO - 10.3136/fstr.11.373

M3 - Article

AN - SCOPUS:37849185542

VL - 11

SP - 373

EP - 375

JO - Food Science and Technology Research

JF - Food Science and Technology Research

SN - 1344-6606

IS - 4

ER -