A family study of a mother and daughter with increased susceptibility to early-onset periodontitis: microbiological, immunological, host defensive, and genetic analyses.

F. Nishimura, A. Nagai, K. Kurimoto, O. Isoshima, Shogo Takashiba, M. Kobayashi, I. Akutsu, H. Kurihara, Y. Nomura, Y. Murayama

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Abstract

Microbiological, immunological, host-defensive, and genetic analyses were performed on a mother and daughter, both of whom had early-onset periodontitis (rapidly progressive periodontitis in the mother; localized juvenile periodontitis in the daughter). Microscopic examination revealed a greatly elevated percentage of rod-form bacteria in both subjects. Fusobacterium sp. and Porphyromonas gingivalis (formerly Bacteroides gingivalis) were the predominant microorganisms cultured. The humoral immune responses to F. nucleatum, P. gingivalis, and Actinobacillus actinomycetemcomitans were much higher in both subjects than those to any other periodontal bacteria examined. Functional and phenotypic analysis of the peripheral lymphocytes showed no significant abnormalities. However, investigation of neutrophil function showed that the mother had depressed neutrophil chemotaxis and superoxide production. The daughter had depression not only of chemotaxis and superoxide production, but also of neutrophil phagocytosis. Serological typing of HLA antigens revealed the same Class II HLA profile in both subjects. It was concluded that both subjects very probably had an identical condition and that these patients provided a unique model for improving our understanding of the host factors involved in periodontal disease.

Original languageEnglish
Pages (from-to)755-762
Number of pages8
JournalJournal of Periodontology
Volume61
Issue number12
Publication statusPublished - Dec 1990

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Aggressive Periodontitis
Porphyromonas gingivalis
Nuclear Family
Neutrophils
Mothers
Chemotaxis
Superoxides
Fusobacterium
Bacteria
Aggregatibacter actinomycetemcomitans
Periodontitis
Periodontal Diseases
Humoral Immunity
HLA Antigens
Phagocytosis
Lymphocytes
Depression

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

A family study of a mother and daughter with increased susceptibility to early-onset periodontitis : microbiological, immunological, host defensive, and genetic analyses. / Nishimura, F.; Nagai, A.; Kurimoto, K.; Isoshima, O.; Takashiba, Shogo; Kobayashi, M.; Akutsu, I.; Kurihara, H.; Nomura, Y.; Murayama, Y.

In: Journal of Periodontology, Vol. 61, No. 12, 12.1990, p. 755-762.

Research output: Contribution to journalArticle

Nishimura, F, Nagai, A, Kurimoto, K, Isoshima, O, Takashiba, S, Kobayashi, M, Akutsu, I, Kurihara, H, Nomura, Y & Murayama, Y 1990, 'A family study of a mother and daughter with increased susceptibility to early-onset periodontitis: microbiological, immunological, host defensive, and genetic analyses.', Journal of Periodontology, vol. 61, no. 12, pp. 755-762.
Nishimura, F. ; Nagai, A. ; Kurimoto, K. ; Isoshima, O. ; Takashiba, Shogo ; Kobayashi, M. ; Akutsu, I. ; Kurihara, H. ; Nomura, Y. ; Murayama, Y. / A family study of a mother and daughter with increased susceptibility to early-onset periodontitis : microbiological, immunological, host defensive, and genetic analyses. In: Journal of Periodontology. 1990 ; Vol. 61, No. 12. pp. 755-762.
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