Abstract
Serum-free medium conditioned by exposure to rabbit costal chondrocytes in culture inhibited the proliferation and DNA synthesis of bovine pulmonary endothelial cells in culture. The factor in conditioned medium did not inhibit DNA synthesis in B16 melanoma cells, L1210 cells or 3T3 fibroblasts in culture, but it inhibited angiogenesis in the chorioallantoic membrane of chick embryos induced by B16 melanoma and growth of the tumor transplanted onto the membrane. These findings strongly suggest that rabbit costal chondrocytes produce an anti-angiogenesis factor that is similar to cartilage-derived anti-tumor factor (CATF).
| Original language | English |
|---|---|
| Pages (from-to) | 357-363 |
| Number of pages | 7 |
| Journal | Biochemistry International |
| Volume | 14 |
| Issue number | 2 |
| Publication status | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma : Its relation with cartilage-derived anti-tumor factor (CATF). / Takigawa, Masaharu; Shirai, E.; Enomoto, M.; Pan, H. O.; Suzuki, F.; Shiio, T.; Yugari, Y.
In: Biochemistry International, Vol. 14, No. 2, 1987, p. 357-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma
T2 - Its relation with cartilage-derived anti-tumor factor (CATF)
AU - Takigawa, Masaharu
AU - Shirai, E.
AU - Enomoto, M.
AU - Pan, H. O.
AU - Suzuki, F.
AU - Shiio, T.
AU - Yugari, Y.
PY - 1987
Y1 - 1987
N2 - Serum-free medium conditioned by exposure to rabbit costal chondrocytes in culture inhibited the proliferation and DNA synthesis of bovine pulmonary endothelial cells in culture. The factor in conditioned medium did not inhibit DNA synthesis in B16 melanoma cells, L1210 cells or 3T3 fibroblasts in culture, but it inhibited angiogenesis in the chorioallantoic membrane of chick embryos induced by B16 melanoma and growth of the tumor transplanted onto the membrane. These findings strongly suggest that rabbit costal chondrocytes produce an anti-angiogenesis factor that is similar to cartilage-derived anti-tumor factor (CATF).
AB - Serum-free medium conditioned by exposure to rabbit costal chondrocytes in culture inhibited the proliferation and DNA synthesis of bovine pulmonary endothelial cells in culture. The factor in conditioned medium did not inhibit DNA synthesis in B16 melanoma cells, L1210 cells or 3T3 fibroblasts in culture, but it inhibited angiogenesis in the chorioallantoic membrane of chick embryos induced by B16 melanoma and growth of the tumor transplanted onto the membrane. These findings strongly suggest that rabbit costal chondrocytes produce an anti-angiogenesis factor that is similar to cartilage-derived anti-tumor factor (CATF).
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UR - http://www.scopus.com/inward/citedby.url?scp=0023131697&partnerID=8YFLogxK
M3 - Article
C2 - 2437926
AN - SCOPUS:0023131697
VL - 14
SP - 357
EP - 363
JO - IUBMB Life
JF - IUBMB Life
SN - 1521-6543
IS - 2
ER -