Abstract
Serum-free medium conditioned by exposure to rabbit costal chondrocytes in culture inhibited the proliferation and DNA synthesis of bovine pulmonary endothelial cells in culture. The factor in conditioned medium did not inhibit DNA synthesis in B16 melanoma cells, L1210 cells or 3T3 fibroblasts in culture, but it inhibited angiogenesis in the chorioallantoic membrane of chick embryos induced by B16 melanoma and growth of the tumor transplanted onto the membrane. These findings strongly suggest that rabbit costal chondrocytes produce an anti-angiogenesis factor that is similar to cartilage-derived anti-tumor factor (CATF).
| Original language | English |
|---|---|
| Pages (from-to) | 357-363 |
| Number of pages | 7 |
| Journal | Biochemistry International |
| Volume | 14 |
| Issue number | 2 |
| Publication status | Published - Aug 4 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Takigawa, M., Shirai, E., Enomoto, M., Pan, H. O., Suzuki, F., Shiio, T., & Yugari, Y. (1987). A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma: Its relation with cartilage-derived anti-tumor factor (CATF). Biochemistry International, 14(2), 357-363.