A Facile Synthesis of Trifluoromethylamines by Oxidative Desulfurization-Fluorination of Dithiocarbamates

Kiyoshi Kanie, Katsuya Mizuno, Manabu Kuroboshi, Tamejiro Hiyama

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Trifluoromethylamines are easily synthesized from dithiocarbamates by a reagent system consisting of tetrabutylammonium dihydrogentrifluoride and an N-halo imide under mild conditions. When this reaction was applied to dithiocarbamates ArN(R)CS2Me at higher temperatures, the trifluoromethylation was accompanied by halogen substitution at the p-position of the Ar group. The synthesis of trifluoromethyl-substituted adenosine is also described.

Original languageEnglish
Pages (from-to)1973-1991
Number of pages19
JournalBulletin of the Chemical Society of Japan
Volume71
Issue number8
DOIs
Publication statusPublished - Aug 1998

    Fingerprint

ASJC Scopus subject areas

  • Chemistry(all)

Cite this