A facile synthesis of C(3)-alkenyl substituted cephems through addition-cyclization of allenecarboxylates derived from penicillin

Hideo Tanaka, Yutaka Kameyama, Shin ichi Sumida, Sigeru Torii

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A short-cut route to cephalosporins bearing alkenyl substituents on the C(3)-position through copper(I) chloride-promoted Michael-type addition of alkenyltributyltins to allenecarboxylates, derived from penicillin, is described.

Original languageEnglish
Pages (from-to)7029-7030
Number of pages2
JournalTetrahedron Letters
Volume33
Issue number46
DOIs
Publication statusPublished - Nov 10 1992

Keywords

  • 3-Alkenylcephems
  • Allenecarboxylates
  • Penicillin-cephalosporin Conversion

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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