A facile synthesis of 5′-end solid-anchored, 3′-end free oligodeoxyribonucleotides via the (5′→3′)-elongated phosphoramidite strategy

Akira Sakakura; Yoshihiro Hayakawa

doi:10.1081/NCN-100002082

A facile synthesis of 5′-end solid-anchored, 3′-end free oligodeoxyribonucleotides via the (5′→3′)-elongated phosphoramidite strategy

Research output: Contribution to journal › Article › peer-review

Abstract

It is demonstrated that not only N²- but also O ⁶-protection of the guanine base is necessary for obtaining the oligodeoxyribonucleotides in high yields and at a high purity in the solid-phase synthesis via the (5′ → 3′)-chain elongated phosphoramidite approach.

Original language	English
Pages (from-to)	213-227
Number of pages	15
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	20
Issue number	3
DOIs	https://doi.org/10.1081/NCN-100002082
Publication status	Published - Jan 1 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Genetics

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abstract = "It is demonstrated that not only N2- but also O 6-protection of the guanine base is necessary for obtaining the oligodeoxyribonucleotides in high yields and at a high purity in the solid-phase synthesis via the (5′ → 3′)-chain elongated phosphoramidite approach.",

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