A facile synthesis of 5′-end solid-anchored, 3′-end free oligodeoxyribonucleotides via the (5′→3′)-elongated phosphoramidite strategy

Akira Sakakura, Yoshihiro Hayakawa

Research output: Contribution to journalArticlepeer-review

Abstract

It is demonstrated that not only N2- but also O 6-protection of the guanine base is necessary for obtaining the oligodeoxyribonucleotides in high yields and at a high purity in the solid-phase synthesis via the (5′ → 3′)-chain elongated phosphoramidite approach.

Original languageEnglish
Pages (from-to)213-227
Number of pages15
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number3
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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