Abstract
A convenient synthesis of 2-exo-methylenepenams 1 is performed by reductive cyclization of allenecarboxylates 8 in a BiCl3/Zn bimetal redox system; subsequent manipulation of the 2-exo-methylene moiety of 1 opens new entries to β-lactam antibiotics and/or β-lactamase inhibitors.
Original language | English |
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Pages (from-to) | 1793-1794 |
Number of pages | 2 |
Journal | Journal of the Chemical Society, Chemical Communications |
Issue number | 24 |
DOIs | |
Publication status | Published - Dec 1 1992 |
ASJC Scopus subject areas
- Molecular Medicine