A convenient synthesis of 2-exo-methylenepenams 1 is performed by reductive cyclization of allenecarboxylates 8 in a BiCl3/Zn bimetal redox system; subsequent manipulation of the 2-exo-methylene moiety of 1 opens new entries to β-lactam antibiotics and/or β-lactamase inhibitors.
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - Dec 1 1992|
ASJC Scopus subject areas
- Molecular Medicine