A facile synthesis of 2-exo-methylenepenam; A potent intermediate for syntheses of new β-lactamase inhibitors

Hideo Tanaka, Yutaka Kameyama, Takahito Yamauchi, Sigeru Torii

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A convenient synthesis of 2-exo-methylenepenams 1 is performed by reductive cyclization of allenecarboxylates 8 in a BiCl3/Zn bimetal redox system; subsequent manipulation of the 2-exo-methylene moiety of 1 opens new entries to β-lactam antibiotics and/or β-lactamase inhibitors.

Original languageEnglish
Pages (from-to)1793-1794
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number24
DOIs
Publication statusPublished - Dec 1 1992

ASJC Scopus subject areas

  • Molecular Medicine

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