A facile access to 3-allyl- and 3-benzyl-3-cephems via reductive addition/cylization of allenecarboxylate with allyl and benzyl halides in an Al/Pb/Ni redox system

Hideo Tanaka, Shin Ichi Sumida, Kouichi Sorajo, Sigeru Torii

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17 Citations (Scopus)

Abstract

A sequential reductive addition/cyclization reaction of allenecarboyxlate, derived from penicillin G, with allyl and benzyl halides was successfully performed by the aid of aluminium metal ad catalytic amounts of PbBr2 and [NiCl2(bipy)] to afford 3-allyl- and 3-benzyl-3-cephems, respectively.

Original languageEnglish
Pages (from-to)1461-1462
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number12
DOIs
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Molecular Medicine

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