Abstract
A sequential reductive addition/cyclization reaction of allenecarboyxlate, derived from penicillin G, with allyl and benzyl halides was successfully performed by the aid of aluminium metal ad catalytic amounts of PbBr2 and [NiCl2(bipy)] to afford 3-allyl- and 3-benzyl-3-cephems, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1461-1462 |
| Number of pages | 2 |
| Journal | Journal of the Chemical Society, Chemical Communications |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 1994 |
ASJC Scopus subject areas
- Molecular Medicine
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Tanaka, H., Sumida, S. I., Sorajo, K., & Torii, S. (1994). A facile access to 3-allyl- and 3-benzyl-3-cephems via reductive addition/cylization of allenecarboxylate with allyl and benzyl halides in an Al/Pb/Ni redox system. Journal of the Chemical Society, Chemical Communications, (12), 1461-1462. https://doi.org/10.1039/C39940001461