A facile access to 3-allyl- and 3-benzyl-3-cephems via reductive addition/cylization of allenecarboxylate with allyl and benzyl halides in an Al/Pb/Ni redox system

Hideo Tanaka, Shin Ichi Sumida, Kouichi Sorajo, Sigeru Torii

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A sequential reductive addition/cyclization reaction of allenecarboyxlate, derived from penicillin G, with allyl and benzyl halides was successfully performed by the aid of aluminium metal ad catalytic amounts of PbBr2 and [NiCl2(bipy)] to afford 3-allyl- and 3-benzyl-3-cephems, respectively.

Original languageEnglish
Pages (from-to)1461-1462
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number12
DOIs
Publication statusPublished - 1994

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Penicillin G
Cyclization
Aluminum
Oxidation-Reduction
Metals

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

A facile access to 3-allyl- and 3-benzyl-3-cephems via reductive addition/cylization of allenecarboxylate with allyl and benzyl halides in an Al/Pb/Ni redox system. / Tanaka, Hideo; Sumida, Shin Ichi; Sorajo, Kouichi; Torii, Sigeru.

In: Journal of the Chemical Society, Chemical Communications, No. 12, 1994, p. 1461-1462.

Research output: Contribution to journalArticle

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abstract = "A sequential reductive addition/cyclization reaction of allenecarboyxlate, derived from penicillin G, with allyl and benzyl halides was successfully performed by the aid of aluminium metal ad catalytic amounts of PbBr2 and [NiCl2(bipy)] to afford 3-allyl- and 3-benzyl-3-cephems, respectively.",
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AU - Sumida, Shin Ichi

AU - Sorajo, Kouichi

AU - Torii, Sigeru

PY - 1994

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