A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

Cameron J. Turtle, Hillary M. Swanson, Nobuharu Fujii, Elihu H. Estey, Stanley R. Riddell

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

The mechanisms that maintain human T cell memory during normal and perturbed homeostasis are not fully understood. The repeated induction of profound lymphocytopenia in patients undergoing multiple cycles of cytotoxic chemotherapy infrequently results in severe infections with viruses controlled by memory T cells, suggesting that some memory T cells survive chemotherapy and restore immunity. Here, we identified a distinct subpopulation of memory CD8+ T cells with the ability to rapidly efflux and survive exposure to chemotherapy drugs in vitro and in vivo. T cells with high efflux capacity shared expression of molecules with hematopoietic stem cells, were quiescent in nonlymphocytopenic individuals, and were induced to proliferate in patients rendered lymphocytopenic after chemotherapy. Effluxing T cells differentiated into noneffluxing subsets in response to antigen stimulation and inflammatory signals, thereby contributing to repopulation of memory cells after chemotherapy.

Original languageEnglish
Pages (from-to)834-844
Number of pages11
JournalImmunity
Volume31
Issue number5
DOIs
Publication statusPublished - Nov 20 2009
Externally publishedYes

Keywords

  • CELLIMMUNO
  • HUMDISEASE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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