A cytotoxic principle of Tamarindus indica, di-n-butyl malate and the structure-activity relationship of its analogues.

A. Kobayashi, M. I. Adenan, S. Kajiyama, Hiroshi Kanzaki, K. Kawazu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the methanolic extract of Tamarindus indica fruits led to the isolation of L-(-)-di-n-butyl malate which exhibited a pronounced cytotoxic activity against sea urchin embryo cells. In order to study structure-activity relationships, close-structure relatives of di-n-butyl malate were synthesized using D-(+)- and L-(-)-malic acid as starting materials, and their cytotoxic activities were examined for the sea urchin embryo assay. L-(-)-Di-n-pentyl malate was the most effective inhibitor to the development of the fertilized eggs. Significant inhibitory activity was not seen in the esters of D-(-)-isomer.

Original languageEnglish
Pages (from-to)233-242
Number of pages10
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume51
Issue number3-4
Publication statusPublished - Mar 1996

Fingerprint

Tamarindus
Tamarindus indica
structure-activity relationships
malates
Structure-Activity Relationship
Sea Urchins
Echinoidea
embryo (animal)
Embryonic Structures
Bioassay
Zygote
malic acid
Fractionation
Fruits
Isomers
Biological Assay
isomers
Assays
Fruit
fractionation

Keywords

  • Cytotoxic Compound
  • Di-n-butyl Malate
  • Sea Urchin Eggs
  • Structure-Activity Relationship
  • Tamarindus indica

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

A cytotoxic principle of Tamarindus indica, di-n-butyl malate and the structure-activity relationship of its analogues. / Kobayashi, A.; Adenan, M. I.; Kajiyama, S.; Kanzaki, Hiroshi; Kawazu, K.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 51, No. 3-4, 03.1996, p. 233-242.

Research output: Contribution to journalArticle

Kobayashi, A. ; Adenan, M. I. ; Kajiyama, S. ; Kanzaki, Hiroshi ; Kawazu, K. / A cytotoxic principle of Tamarindus indica, di-n-butyl malate and the structure-activity relationship of its analogues. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 1996 ; Vol. 51, No. 3-4. pp. 233-242.
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