A Cytotoxic Principle of Tamarindus indica, Di-n-butyl Malate and the Structure-Activity Relationship of Its Analogues

Akio Kobayashi, Shin Ichiro Kajiyama, Mohd Ilham Adenan, Hiroshi Kanzaki, Kazuyoshi Kawazu

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the methanolic extract of Tamarindus indica fruits led to the isolation of l-(-)-di-/n-butyl malate which exhibited a pronounced cytotoxic activity against sea urchin embryo cells. In order to study structure-activity relationships, close-structure relatives of di-n-butyl malate were synthesized using d-(+)- and l-(-)-malic acid as starting materials, and their cytotoxic activities were examined for the sea urchin embryo assay. l-(-)-Di-n-pentyl malate was the most effective inhibitor to the development of the fertilized eggs. Significant inhibitory activity was not seen in the esters of d-(-)-isomer.

Original languageEnglish
Pages (from-to)233-242
Number of pages10
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume51
Issue number3
DOIs
Publication statusPublished - Jan 1996

Keywords

  • Cytotoxic Compound
  • Di-/n-butyl Malate
  • Sea Urchin Eggs
  • Structure-Activity Relationship
  • Tamarindus indica

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'A Cytotoxic Principle of Tamarindus indica, Di-n-butyl Malate and the Structure-Activity Relationship of Its Analogues'. Together they form a unique fingerprint.

Cite this