A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses

Pavan Reddy, Yoshinobu Maeda, Chen Liu, Oleg I. Krijanovski, Robert Korngold, James L.M. Ferrara

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Graft-versus-leukemia (GVL) response after allogeneic bone marrow transplantation (BMT) represents one of the most potent forms of immunotherapy against malignant diseases1. Antigen-presenting cells (APCs) are crucial for the induction of graft-versus-host disease (GVHD)2-6, the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.

Original languageEnglish
Pages (from-to)1244-1249
Number of pages6
JournalNature Medicine
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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