A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses

Pavan Reddy; Yoshinobu Maeda; Chen Liu; Oleg I. Krijanovski; Robert Korngold; James L.M. Ferrara

doi:10.1038/nm1309

A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses

Pavan Reddy, Yoshinobu Maeda, Chen Liu, Oleg I. Krijanovski, Robert Korngold, James L.M. Ferrara

Research output: Contribution to journal › Article › peer-review

182 Citations (Scopus)

Abstract

Graft-versus-leukemia (GVL) response after allogeneic bone marrow transplantation (BMT) represents one of the most potent forms of immunotherapy against malignant diseases¹. Antigen-presenting cells (APCs) are crucial for the induction of graft-versus-host disease (GVHD)^2-6, the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.

Original language	English
Pages (from-to)	1244-1249
Number of pages	6
Journal	Nature Medicine
Volume	11
Issue number	11
DOIs	https://doi.org/10.1038/nm1309
Publication status	Published - Nov 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses",

abstract = "Graft-versus-leukemia (GVL) response after allogeneic bone marrow transplantation (BMT) represents one of the most potent forms of immunotherapy against malignant diseases1. Antigen-presenting cells (APCs) are crucial for the induction of graft-versus-host disease (GVHD)2-6, the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.",

author = "Pavan Reddy and Yoshinobu Maeda and Chen Liu and Krijanovski, {Oleg I.} and Robert Korngold and Ferrara, {James L.M.}",

note = "Funding Information: This work was supported by US National Institutes of Health grants K08 AI052863-01 (to P.R.), PO1 CA 49542 (to J.L.M.F.) and R01 HL55593 (to R.K). P.R. is the recipient of the Alaina J. Enlow Scholar Award from Amy Strelzer Manasevit – National Marrow Donor Program and the New Investigator Award from American Society of Blood and Marrow Transplantation. J.L.M.F. is a recipient of the Doris Duke Distinguished Clinical Scientist Award.",

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AU - Krijanovski, Oleg I.

AU - Korngold, Robert

AU - Ferrara, James L.M.

N1 - Funding Information: This work was supported by US National Institutes of Health grants K08 AI052863-01 (to P.R.), PO1 CA 49542 (to J.L.M.F.) and R01 HL55593 (to R.K). P.R. is the recipient of the Alaina J. Enlow Scholar Award from Amy Strelzer Manasevit – National Marrow Donor Program and the New Investigator Award from American Society of Blood and Marrow Transplantation. J.L.M.F. is a recipient of the Doris Duke Distinguished Clinical Scientist Award.

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A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses

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