Abstract
Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.
Original language | English |
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Pages (from-to) | 21-29 |
Number of pages | 9 |
Journal | Environmental Health and Preventive Medicine |
Volume | 19 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Externally published | Yes |
Keywords
- Cross-sectional study
- Handgrip strength
- Lifestyle
- Older persons
- Oxidative stress
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health