A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Basilua Andre Muzembo; Yasunori Nagano; Masamitsu Eitoku; Nlandu Roger Ngatu; Tomomi Matsui; Sabah Asif Bhatti; Ryoji Hirota; Kenji Ishida; Narufumi Suganuma

doi:10.1007/s12199-013-0350-x

A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Basilua Andre Muzembo, Yasunori Nagano, Masamitsu Eitoku, Nlandu Roger Ngatu, Tomomi Matsui, Sabah Asif Bhatti, Ryoji Hirota, Kenji Ishida, Narufumi Suganuma

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

Original language	English
Pages (from-to)	21-29
Number of pages	9
Journal	Environmental Health and Preventive Medicine
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s12199-013-0350-x
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Cross-sectional study
Handgrip strength
Lifestyle
Older persons
Oxidative stress

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12199-013-0350-x

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A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community. / Muzembo, Basilua Andre; Nagano, Yasunori; Eitoku, Masamitsu; Ngatu, Nlandu Roger; Matsui, Tomomi; Bhatti, Sabah Asif; Hirota, Ryoji; Ishida, Kenji; Suganuma, Narufumi.

In: Environmental Health and Preventive Medicine, Vol. 19, No. 1, 01.2014, p. 21-29.

Research output: Contribution to journal › Article › peer-review

Muzembo, Basilua Andre ; Nagano, Yasunori ; Eitoku, Masamitsu ; Ngatu, Nlandu Roger ; Matsui, Tomomi ; Bhatti, Sabah Asif ; Hirota, Ryoji ; Ishida, Kenji ; Suganuma, Narufumi. / A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community. In: Environmental Health and Preventive Medicine. 2014 ; Vol. 19, No. 1. pp. 21-29.

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abstract = "Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.",

keywords = "Cross-sectional study, Handgrip strength, Lifestyle, Older persons, Oxidative stress",

author = "Muzembo, {Basilua Andre} and Yasunori Nagano and Masamitsu Eitoku and Ngatu, {Nlandu Roger} and Tomomi Matsui and Bhatti, {Sabah Asif} and Ryoji Hirota and Kenji Ishida and Narufumi Suganuma",

note = "Funding Information: Acknowledgments This work was financially supported by funding from Kochi University and city office of Kuroshio town, Kochi prefecture, Japan. The authors wish to thank the elderly people who participated in this study. They are also grateful to Mr. Daniel Ribble, Mr Mugo Andrew, and Ms Mansongi Biyela Carine for their advice on the manuscript.",

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doi = "10.1007/s12199-013-0350-x",

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AU - Eitoku, Masamitsu

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AU - Matsui, Tomomi

AU - Bhatti, Sabah Asif

AU - Hirota, Ryoji

AU - Ishida, Kenji

AU - Suganuma, Narufumi

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PY - 2014/1

Y1 - 2014/1

N2 - Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

AB - Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

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KW - Oxidative stress

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A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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