A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Basilua Andre Muzembo, Yasunori Nagano, Masamitsu Eitoku, Nlandu Roger Ngatu, Tomomi Matsui, Sabah Asif Bhatti, Ryoji Hirota, Kenji Ishida, Narufumi Suganuma

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′- deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalEnvironmental Health and Preventive Medicine
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2014
Externally publishedYes

Keywords

  • Cross-sectional study
  • Handgrip strength
  • Lifestyle
  • Older persons
  • Oxidative stress

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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