Synthesis of the AB ring segments of ciguatoxin is described. The present synthesis includes a Lewis acid mediated cyclization of allylstannane with aldehyde, cross-metathesis reaction introducing the side chain, and Grieco-Nishizawa dehydration on the A ring.
- Allylstannane-aldehyde condensation
- Polycyclic ethers
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery