A convenient synthesis of luotonins A and B

Takashi Harayama, Yoshiaki Morikami, Yasumi Shigeta, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.

Original languageEnglish
Pages (from-to)847-848
Number of pages2
JournalSynlett
Issue number6
Publication statusPublished - 2003

Fingerprint

Alkaloids
luotonin A
luotonin B

Keywords

  • Cytotoxic activity
  • Palladium
  • Pyrroloquinazoline alkaloid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Harayama, T., Morikami, Y., Shigeta, Y., Abe, H., & Takeuchi, Y. (2003). A convenient synthesis of luotonins A and B. Synlett, (6), 847-848.

A convenient synthesis of luotonins A and B. / Harayama, Takashi; Morikami, Yoshiaki; Shigeta, Yasumi; Abe, Hitoshi; Takeuchi, Yasuo.

In: Synlett, No. 6, 2003, p. 847-848.

Research output: Contribution to journalArticle

Harayama, T, Morikami, Y, Shigeta, Y, Abe, H & Takeuchi, Y 2003, 'A convenient synthesis of luotonins A and B', Synlett, no. 6, pp. 847-848.
Harayama T, Morikami Y, Shigeta Y, Abe H, Takeuchi Y. A convenient synthesis of luotonins A and B. Synlett. 2003;(6):847-848.
Harayama, Takashi ; Morikami, Yoshiaki ; Shigeta, Yasumi ; Abe, Hitoshi ; Takeuchi, Yasuo. / A convenient synthesis of luotonins A and B. In: Synlett. 2003 ; No. 6. pp. 847-848.
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