A convenient synthesis of luotonins A and B

Takashi Harayama, Yoshiaki Morikami, Yasumi Shigeta, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.

Original languageEnglish
Pages (from-to)847-848
Number of pages2
JournalSynlett
Issue number6
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Cytotoxic activity
  • Palladium
  • Pyrroloquinazoline alkaloid

ASJC Scopus subject areas

  • Organic Chemistry

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