Abstract
Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.
| Original language | English |
|---|---|
| Pages (from-to) | 847-848 |
| Number of pages | 2 |
| Journal | Synlett |
| Issue number | 6 |
| Publication status | Published - 2003 |
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Keywords
- Cytotoxic activity
- Palladium
- Pyrroloquinazoline alkaloid
ASJC Scopus subject areas
- Organic Chemistry
Cite this
A convenient synthesis of luotonins A and B. / Harayama, Takashi; Morikami, Yoshiaki; Shigeta, Yasumi; Abe, Hitoshi; Takeuchi, Yasuo.
In: Synlett, No. 6, 2003, p. 847-848.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A convenient synthesis of luotonins A and B
AU - Harayama, Takashi
AU - Morikami, Yoshiaki
AU - Shigeta, Yasumi
AU - Abe, Hitoshi
AU - Takeuchi, Yasuo
PY - 2003
Y1 - 2003
N2 - Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.
AB - Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.
KW - Cytotoxic activity
KW - Palladium
KW - Pyrroloquinazoline alkaloid
UR - http://www.scopus.com/inward/record.url?scp=0037617927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037617927&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0037617927
SP - 847
EP - 848
JO - Synlett
JF - Synlett
SN - 0936-5214
IS - 6
ER -