A convenient synthesis of luotonins A and B

Takashi Harayama; Yoshiaki Morikami; Yasumi Shigeta; Hitoshi Abe; Yasuo Takeuchi

doi:10.1055/s-2003-38748

A convenient synthesis of luotonins A and B

Takashi Harayama, Yoshiaki Morikami, Yasumi Shigeta, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy₃P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO₃ gave luotonin B in good yield.

Original language	English
Pages (from-to)	847-848
Number of pages	2
Journal	Synlett
Issue number	6
DOIs	https://doi.org/10.1055/s-2003-38748
Publication status	Published - Jan 1 2003

Keywords

Cytotoxic activity
Palladium
Pyrroloquinazoline alkaloid

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-2003-38748

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abstract = "Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.",

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author = "Takashi Harayama and Yoshiaki Morikami and Yasumi Shigeta and Hitoshi Abe and Yasuo Takeuchi",

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T1 - A convenient synthesis of luotonins A and B

AU - Harayama, Takashi

AU - Morikami, Yoshiaki

AU - Shigeta, Yasumi

AU - Abe, Hitoshi

AU - Takeuchi, Yasuo

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.

AB - Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.

KW - Cytotoxic activity

KW - Palladium

KW - Pyrroloquinazoline alkaloid

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ER -

A convenient synthesis of luotonins A and B

Abstract

Keywords

ASJC Scopus subject areas

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