Abstract
Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO3 gave luotonin B in good yield.
Original language | English |
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Pages (from-to) | 847-848 |
Number of pages | 2 |
Journal | Synlett |
Issue number | 6 |
DOIs | |
Publication status | Published - Jan 1 2003 |
Keywords
- Cytotoxic activity
- Palladium
- Pyrroloquinazoline alkaloid
ASJC Scopus subject areas
- Organic Chemistry