A convenient synthesis of luotonins A and B

Takashi Harayama; Yoshiaki Morikami; Yasumi Shigeta; Hitoshi Abe; Yasuo Takeuchi

doi:10.1055/s-2003-38748

A convenient synthesis of luotonins A and B

Takashi Harayama, Yoshiaki Morikami, Yasumi Shigeta, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journal › Article

49 Citations (Scopus)

Abstract

Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy₃P and KOAc in high yield. Successive treatment of luotonin A with NBS and aqAgNO₃ gave luotonin B in good yield.

Original language	English
Pages (from-to)	847-848
Number of pages	2
Journal	Synlett
Issue number	6
DOIs	https://doi.org/10.1055/s-2003-38748
Publication status	Published - Jan 1 2003

Keywords

Cytotoxic activity
Palladium
Pyrroloquinazoline alkaloid

ASJC Scopus subject areas

Organic Chemistry

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Harayama, T., Morikami, Y., Shigeta, Y., Abe, H., & Takeuchi, Y. (2003). A convenient synthesis of luotonins A and B. Synlett, (6), 847-848. https://doi.org/10.1055/s-2003-38748

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