A convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (I)

A synthesis of methoxy- and hydroxycoumarins

Takashi Harayama, Keiko Katsuno, Hiromi Nishioka, Masako Fujii, Yoshitaka Nishita, Hisashi Ishii, Yasuko Kaneko

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Reaction of methoxy- and hydroxysalicylaldehydes (1) with phosphorane in diethylaniline under reflux gave only coumarins (3) in high yields except for 3-methoxysalicylaldehyde (1b). It was clarified that methoxy group(s) at C4 and C6 on 1 facilitated the formation of 3.

Original languageEnglish
Pages (from-to)613-622
Number of pages10
JournalHeterocycles
Volume39
Issue number2
Publication statusPublished - Dec 31 1994

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Phosphoranes
Coumarins
salicylaldehyde
coumarin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (I) : A synthesis of methoxy- and hydroxycoumarins. / Harayama, Takashi; Katsuno, Keiko; Nishioka, Hiromi; Fujii, Masako; Nishita, Yoshitaka; Ishii, Hisashi; Kaneko, Yasuko.

In: Heterocycles, Vol. 39, No. 2, 31.12.1994, p. 613-622.

Research output: Contribution to journalArticle

Harayama, T, Katsuno, K, Nishioka, H, Fujii, M, Nishita, Y, Ishii, H & Kaneko, Y 1994, 'A convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (I): A synthesis of methoxy- and hydroxycoumarins', Heterocycles, vol. 39, no. 2, pp. 613-622.
Harayama, Takashi ; Katsuno, Keiko ; Nishioka, Hiromi ; Fujii, Masako ; Nishita, Yoshitaka ; Ishii, Hisashi ; Kaneko, Yasuko. / A convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (I) : A synthesis of methoxy- and hydroxycoumarins. In: Heterocycles. 1994 ; Vol. 39, No. 2. pp. 613-622.
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