A convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (I): A synthesis of methoxy- and hydroxycoumarins

Takashi Harayama, Keiko Katsuno, Hiromi Nishioka, Masako Fujii, Yoshitaka Nishita, Hisashi Ishii, Yasuko Kaneko

Research output: Contribution to journalArticle

32 Citations (Scopus)


Reaction of methoxy- and hydroxysalicylaldehydes (1) with phosphorane in diethylaniline under reflux gave only coumarins (3) in high yields except for 3-methoxysalicylaldehyde (1b). It was clarified that methoxy group(s) at C4 and C6 on 1 facilitated the formation of 3.

Original languageEnglish
Pages (from-to)613-622
Number of pages10
Issue number2
Publication statusPublished - Dec 31 1994


ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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