A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins

Kazuki Tanifuji, Norihiro Yamada, Tomoyuki Tajima, Takahiro Sasamori, Norihiro Tokitoh, Tsukasa Matsuo, Kohei Tamao, Yasuhiro Ohki, Kazuyuki Tatsumi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An amide-bound [Fe4S4]3+ cluster, [Fe 4S4{N(SiMe3)2}4] - (1), was found to serve as a convenient precursor for synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. Treatment of 1 with 4 equiv of bulky thiols led to replacement of the amide ligands with thiolates, giving rise to a series of [Fe4S4(SR) 4]- clusters (R = Dmp (2a), Tbt (2b), Eind (2c), Dxp (2d), Dpp (2e); Dmp = 2,6-di(mesityl)phenyl, Tbt = 2,4,6-tris[bis(trimethylsilyl) methyl]phenyl, Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl, Dxp = 2,6-di(m-xylyl)phenyl, Dpp = 2,6-diphenylphenyl). These clusters were characterized by the mass spectrum, the EPR spectrum, and X-ray crystallography. The redox potentials of the [Fe4S4]3+/2+ couple, -0.82 V (2a), -0.86 V (2b), -0.84 V (2c), -0.74 V (2d), and -0.63 V (2e) vs Ag/Ag+ in THF, are significantly more negative than that of [Fe4S4(SPh)4]-/2- (-0.21 V).

Original languageEnglish
Pages (from-to)4000-4009
Number of pages10
JournalInorganic Chemistry
Volume53
Issue number8
DOIs
Publication statusPublished - Apr 21 2014
Externally publishedYes

Fingerprint

Amides
sulfur
routes
analogs
proteins
iron
amides
X ray crystallography
X Ray Crystallography
Sulfhydryl Compounds
Oxidation-Reduction
Paramagnetic resonance
Ligands
thiols
mass spectra
crystallography
ligands
high potential iron-sulfur protein
x rays
Bistris

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Tanifuji, K., Yamada, N., Tajima, T., Sasamori, T., Tokitoh, N., Matsuo, T., ... Tatsumi, K. (2014). A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. Inorganic Chemistry, 53(8), 4000-4009. https://doi.org/10.1021/ic402890k

A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. / Tanifuji, Kazuki; Yamada, Norihiro; Tajima, Tomoyuki; Sasamori, Takahiro; Tokitoh, Norihiro; Matsuo, Tsukasa; Tamao, Kohei; Ohki, Yasuhiro; Tatsumi, Kazuyuki.

In: Inorganic Chemistry, Vol. 53, No. 8, 21.04.2014, p. 4000-4009.

Research output: Contribution to journalArticle

Tanifuji, K, Yamada, N, Tajima, T, Sasamori, T, Tokitoh, N, Matsuo, T, Tamao, K, Ohki, Y & Tatsumi, K 2014, 'A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins', Inorganic Chemistry, vol. 53, no. 8, pp. 4000-4009. https://doi.org/10.1021/ic402890k
Tanifuji, Kazuki ; Yamada, Norihiro ; Tajima, Tomoyuki ; Sasamori, Takahiro ; Tokitoh, Norihiro ; Matsuo, Tsukasa ; Tamao, Kohei ; Ohki, Yasuhiro ; Tatsumi, Kazuyuki. / A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. In: Inorganic Chemistry. 2014 ; Vol. 53, No. 8. pp. 4000-4009.
@article{928ec25a18e142569d533f27c3584fd9,
title = "A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins",
abstract = "An amide-bound [Fe4S4]3+ cluster, [Fe 4S4{N(SiMe3)2}4] - (1), was found to serve as a convenient precursor for synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. Treatment of 1 with 4 equiv of bulky thiols led to replacement of the amide ligands with thiolates, giving rise to a series of [Fe4S4(SR) 4]- clusters (R = Dmp (2a), Tbt (2b), Eind (2c), Dxp (2d), Dpp (2e); Dmp = 2,6-di(mesityl)phenyl, Tbt = 2,4,6-tris[bis(trimethylsilyl) methyl]phenyl, Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl, Dxp = 2,6-di(m-xylyl)phenyl, Dpp = 2,6-diphenylphenyl). These clusters were characterized by the mass spectrum, the EPR spectrum, and X-ray crystallography. The redox potentials of the [Fe4S4]3+/2+ couple, -0.82 V (2a), -0.86 V (2b), -0.84 V (2c), -0.74 V (2d), and -0.63 V (2e) vs Ag/Ag+ in THF, are significantly more negative than that of [Fe4S4(SPh)4]-/2- (-0.21 V).",
author = "Kazuki Tanifuji and Norihiro Yamada and Tomoyuki Tajima and Takahiro Sasamori and Norihiro Tokitoh and Tsukasa Matsuo and Kohei Tamao and Yasuhiro Ohki and Kazuyuki Tatsumi",
year = "2014",
month = "4",
day = "21",
doi = "10.1021/ic402890k",
language = "English",
volume = "53",
pages = "4000--4009",
journal = "Inorganic Chemistry",
issn = "0020-1669",
publisher = "American Chemical Society",
number = "8",

}

TY - JOUR

T1 - A convenient route to synthetic analogues of the oxidized form of high-potential iron-sulfur proteins

AU - Tanifuji, Kazuki

AU - Yamada, Norihiro

AU - Tajima, Tomoyuki

AU - Sasamori, Takahiro

AU - Tokitoh, Norihiro

AU - Matsuo, Tsukasa

AU - Tamao, Kohei

AU - Ohki, Yasuhiro

AU - Tatsumi, Kazuyuki

PY - 2014/4/21

Y1 - 2014/4/21

N2 - An amide-bound [Fe4S4]3+ cluster, [Fe 4S4{N(SiMe3)2}4] - (1), was found to serve as a convenient precursor for synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. Treatment of 1 with 4 equiv of bulky thiols led to replacement of the amide ligands with thiolates, giving rise to a series of [Fe4S4(SR) 4]- clusters (R = Dmp (2a), Tbt (2b), Eind (2c), Dxp (2d), Dpp (2e); Dmp = 2,6-di(mesityl)phenyl, Tbt = 2,4,6-tris[bis(trimethylsilyl) methyl]phenyl, Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl, Dxp = 2,6-di(m-xylyl)phenyl, Dpp = 2,6-diphenylphenyl). These clusters were characterized by the mass spectrum, the EPR spectrum, and X-ray crystallography. The redox potentials of the [Fe4S4]3+/2+ couple, -0.82 V (2a), -0.86 V (2b), -0.84 V (2c), -0.74 V (2d), and -0.63 V (2e) vs Ag/Ag+ in THF, are significantly more negative than that of [Fe4S4(SPh)4]-/2- (-0.21 V).

AB - An amide-bound [Fe4S4]3+ cluster, [Fe 4S4{N(SiMe3)2}4] - (1), was found to serve as a convenient precursor for synthetic analogues of the oxidized form of high-potential iron-sulfur proteins. Treatment of 1 with 4 equiv of bulky thiols led to replacement of the amide ligands with thiolates, giving rise to a series of [Fe4S4(SR) 4]- clusters (R = Dmp (2a), Tbt (2b), Eind (2c), Dxp (2d), Dpp (2e); Dmp = 2,6-di(mesityl)phenyl, Tbt = 2,4,6-tris[bis(trimethylsilyl) methyl]phenyl, Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl, Dxp = 2,6-di(m-xylyl)phenyl, Dpp = 2,6-diphenylphenyl). These clusters were characterized by the mass spectrum, the EPR spectrum, and X-ray crystallography. The redox potentials of the [Fe4S4]3+/2+ couple, -0.82 V (2a), -0.86 V (2b), -0.84 V (2c), -0.74 V (2d), and -0.63 V (2e) vs Ag/Ag+ in THF, are significantly more negative than that of [Fe4S4(SPh)4]-/2- (-0.21 V).

UR - http://www.scopus.com/inward/record.url?scp=84899419684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899419684&partnerID=8YFLogxK

U2 - 10.1021/ic402890k

DO - 10.1021/ic402890k

M3 - Article

VL - 53

SP - 4000

EP - 4009

JO - Inorganic Chemistry

JF - Inorganic Chemistry

SN - 0020-1669

IS - 8

ER -