A consideration on the role of HSP70 appearing in the periodontal tissues due to experimental orthodontic force

Rina Muraoka, Keisuke Nakano, Hirokazu Matsuda, Maki Tomoda, Norimasa Okafuji, Kazuhiro Yamada, Toshiyuki Kawakami

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We examined immunohistochemical expressions of HSP70 and p-HSP70 in the orthodontic periodontal tissues. In the control group, the HSP70 and p-HSP70 expression was observed in the periodontal ligament fibroblasts and that was kept in low levels. In the experimental group, the strong expression of HSP70 was detected according to over time. However, p-HSP70 expression was a bit delayed. The data suggests that HSP70 has been closely involved in the repair of tissue to maintain homeostasis of the periodontal tissues by the activation of periodontal ligament fibroblasts. Farthermore, the data also suggests that HSP70 act as a molecular chaperone of osteogenesis through an activation of osteoblasts.

Original languageEnglish
Pages (from-to)275-282
Number of pages8
JournalJournal of Hard Tissue Biology
Volume20
Issue number4
DOIs
Publication statusPublished - Dec 1 2011
Externally publishedYes

Keywords

  • HSP70
  • Heat shock protein
  • Orthodontic mechanical stress
  • Orthodontic tooth movement
  • Periodontal tissues

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology

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