A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration

Satoshi Hara, Mitsuhiro Kawano, Ichiro Mizushima, Kazunori Yamada, Kentaro Fujita, Kenichi Harada, Masami Matsumura, Masakazu Yamagishi, Yasuharu Sato, Yutaka Yamaguchi, Yasuni Nakanuma, Michio Nagata

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7 Citations (Scopus)

Abstract

We describe a 74-year-old Japanese man with systemic fibroinflammatory conditions closely resembling those of immunoglobulin G4-related disease (IgG4-RD). Radiology and histology showed characteristics of IgG4-related tubulointerstitial nephritis, despite normal serum IgG4 value and scanty IgG4-positive plasma cell infiltration in each organ. This case suggests that a condition closely mimicking IgG4-RD may develop without IgG4-positive plasma cells and those exceptional cases should also be taken into account in the differential diagnosis of IgG4-RD.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalModern Rheumatology
Volume26
Issue number5
DOIs
Publication statusPublished - Sep 2 2016

Keywords

  • IgG4
  • IgG4-related disease
  • Tubulointerstitial nephritis

ASJC Scopus subject areas

  • Rheumatology

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    Hara, S., Kawano, M., Mizushima, I., Yamada, K., Fujita, K., Harada, K., Matsumura, M., Yamagishi, M., Sato, Y., Yamaguchi, Y., Nakanuma, Y., & Nagata, M. (2016). A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Modern Rheumatology, 26(5), 784-789. https://doi.org/10.3109/14397595.2014.916836