A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration

Satoshi Hara, Mitsuhiro Kawano, Ichiro Mizushima, Kazunori Yamada, Kentaro Fujita, Kenichi Harada, Masami Matsumura, Masakazu Yamagishi, Yasuharu Sato, Yutaka Yamaguchi, Yasuni Nakanuma, Michio Nagata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We describe a 74-year-old Japanese man with systemic fibroinflammatory conditions closely resembling those of immunoglobulin G4-related disease (IgG4-RD). Radiology and histology showed characteristics of IgG4-related tubulointerstitial nephritis, despite normal serum IgG4 value and scanty IgG4-positive plasma cell infiltration in each organ. This case suggests that a condition closely mimicking IgG4-RD may develop without IgG4-positive plasma cells and those exceptional cases should also be taken into account in the differential diagnosis of IgG4-RD.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalModern Rheumatology
Volume26
Issue number5
DOIs
Publication statusPublished - Sep 2 2016

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Plasma Cells
Immunoglobulin G
Immunoglobulins
Serum
Interstitial Nephritis
Radiology
Histology
Differential Diagnosis

Keywords

  • IgG4
  • IgG4-related disease
  • Tubulointerstitial nephritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. / Hara, Satoshi; Kawano, Mitsuhiro; Mizushima, Ichiro; Yamada, Kazunori; Fujita, Kentaro; Harada, Kenichi; Matsumura, Masami; Yamagishi, Masakazu; Sato, Yasuharu; Yamaguchi, Yutaka; Nakanuma, Yasuni; Nagata, Michio.

In: Modern Rheumatology, Vol. 26, No. 5, 02.09.2016, p. 784-789.

Research output: Contribution to journalArticle

Hara, S, Kawano, M, Mizushima, I, Yamada, K, Fujita, K, Harada, K, Matsumura, M, Yamagishi, M, Sato, Y, Yamaguchi, Y, Nakanuma, Y & Nagata, M 2016, 'A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration', Modern Rheumatology, vol. 26, no. 5, pp. 784-789. https://doi.org/10.3109/14397595.2014.916836
Hara, Satoshi ; Kawano, Mitsuhiro ; Mizushima, Ichiro ; Yamada, Kazunori ; Fujita, Kentaro ; Harada, Kenichi ; Matsumura, Masami ; Yamagishi, Masakazu ; Sato, Yasuharu ; Yamaguchi, Yutaka ; Nakanuma, Yasuni ; Nagata, Michio. / A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. In: Modern Rheumatology. 2016 ; Vol. 26, No. 5. pp. 784-789.
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AU - Fujita, Kentaro

AU - Harada, Kenichi

AU - Matsumura, Masami

AU - Yamagishi, Masakazu

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