A comprehensive review of ovarian serous carcinoma

Yuichiro Hatano, Kayoko Hatano, Maho Tamada, Ken Ichirou Morishige, Hiroyuki Tomita, Hiroyuki Yanai, Akira Hara

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.

Original languageEnglish
Pages (from-to)329-339
Number of pages11
JournalAdvances in Anatomic Pathology
Issue number5
Publication statusPublished - Sept 1 2019


  • TP53
  • fallopian tube
  • ovary
  • serous carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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