A comprehensive review of ovarian serous carcinoma

Yuichiro Hatano; Kayoko Hatano; Maho Tamada; Ken Ichirou Morishige; Hiroyuki Tomita; Hiroyuki Yanai; Akira Hara

doi:10.1097/PAP.0000000000000243

A comprehensive review of ovarian serous carcinoma

Yuichiro Hatano, Kayoko Hatano, Maho Tamada, Ken Ichirou Morishige, Hiroyuki Tomita, Hiroyuki Yanai, Akira Hara

University Hospital

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.

Original language	English
Pages (from-to)	329-339
Number of pages	11
Journal	Advances in Anatomic Pathology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1097/PAP.0000000000000243
Publication status	Published - Sept 1 2019

Keywords

TP53
fallopian tube
ovary
serous carcinoma

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine

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10.1097/PAP.0000000000000243

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abstract = "Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.",

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AU - Hatano, Yuichiro

AU - Hatano, Kayoko

AU - Tamada, Maho

AU - Morishige, Ken Ichirou

AU - Tomita, Hiroyuki

AU - Yanai, Hiroyuki

AU - Hara, Akira

PY - 2019/9/1

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N2 - Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.

AB - Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.

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A comprehensive review of ovarian serous carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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