A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

T. Tateishi, M. Watanabe, H. Nakura, M. Tanaka, T. Kumai, T. Aoki, S. Kobayashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (cYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1. Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation. Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents. Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.

Original languageEnglish
Pages (from-to)1028-1032
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Volume42
Issue number9
DOIs
Publication statusPublished - Jan 1 1998
Externally publishedYes

Keywords

  • Chlorzoxazone
  • Drug- interaction
  • Enflurane
  • Halothane
  • Isoflurane
  • Rabbits
  • Sevoflurane

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits'. Together they form a unique fingerprint.

Cite this