A comparison of straight- And branch-chained lipid bilayers for static and dynamic properties: A molecular dynamics study

W. Shinoda, M. Mikami, T. Baba, M. Hato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A bilayer composed of branch-chained lipid molecules is generally believed to have high bilayer stability and low ion leakage. To understand how the chain branching affects the bilayer properties on the molecular level, two molecular dynamics simulations of lipid bilayers have been undertaken in the isothermal-isobaric ensemble. The first simulation was carried out on the straight-chained DPPC bilayer, the second on the branch-chained DPhPC. The detailed analyses on the chain conformation revealed that the segmental order of branched chains was lower than that of straight chains. As for the intermolecular packing order in the bilayer plane, however, a relatively neat lipid arrangement was observed for the branch-chained DPhPC bilayer. A significant lowering in the chain mobility was observed as a result of chain branching. The high bilayer stability of the branch-chained DPhPC bilayer would arise from the low chain mobility and the neat lateral arrangement of the lipid in the bilayer.

Original languageEnglish
Title of host publication2003 Nanotechnology Conference and Trade Show - Nanotech 2003
EditorsM. Laudon, B. Romanowicz
Pages512-515
Number of pages4
Publication statusPublished - 2003
Externally publishedYes
Event2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States
Duration: Feb 23 2003Feb 27 2003

Publication series

Name2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Volume3

Conference

Conference2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Country/TerritoryUnited States
CitySan Francisco, CA
Period2/23/032/27/03

Keywords

  • Bilayer stability
  • Branched chain
  • Lipid bilayers
  • Molecular dynamics
  • Permeability

ASJC Scopus subject areas

  • Engineering(all)

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