A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy

Tomonori Tateishi, Hironori Nakura, Masako Asoh, Minoru Watanabe, Masami Tanaka, Toshio Kumai, Sachio Takashima, Susumu Imaoka, Yoshihiko Funae, Yoshiyasu Yabusaki, Tetsuya Kamataki, Shinichi Kobayashi

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115 Citations (Scopus)

Abstract

We immunochemically measured the contents of 9 different cytochrome P450 (CYP) isoenzymes expressed in the liver and compared them between two groups: one group of 6 infant and 4 perinatal patients and one group of 10 patients after infancy (over 1 year old). CYP protein expressed in human liver can be divided into three groups on the basis of expression pattern: (a) CYP2A6, 2C9, 2D6, 2E1, and 3A were present in all samples and no difference was observed between the two groups, (b) CYP1A2, 2B6, and 2C8 were expressed more after infancy than during infancy; and (c) CYP3A7, which has been considered a major CYP enzyme in fetal liver microsomes, was expressed in all infants as well as the four perinatal patients, whereas it was detected in only 2 patients after infancy. These results implied that CYP2A6, 2C9, 2D6, 2E1, and 3A are already expressed during perinatal and infant period, while CYP1A2, 2B6, and 2C8 are expressed highly in subjects over 1 year old, and CYP3A7 disappeared after infancy.

Original languageEnglish
Pages (from-to)2567-2574
Number of pages8
JournalLife Sciences
Volume61
Issue number26
DOIs
Publication statusPublished - Nov 21 1997
Externally publishedYes

Keywords

  • Hepatic cytochrome P450
  • Infancy
  • Perinatal period
  • Postinfancy
  • Western blotting

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Tateishi, T., Nakura, H., Asoh, M., Watanabe, M., Tanaka, M., Kumai, T., Takashima, S., Imaoka, S., Funae, Y., Yabusaki, Y., Kamataki, T., & Kobayashi, S. (1997). A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy. Life Sciences, 61(26), 2567-2574. https://doi.org/10.1016/S0024-3205(97)01011-4