Abstract
We studied 30 patients sedated with dexmedetomidine hydrochloride or propofol under tracheal intubation following oral and maxillofacial surgery at the dental operating room in Okayama University Hospital between November 2005 and August 2006. We compared the effects on amnesia and relief of postoperative discomfort between dexmedetomidine hydrochloride and propofol, analyzing questionnaires completed a week after surgery. Sedation was given to the patients at the sedation levels around a Ramsay Score of 3 or 4. The patients were divided into the dexmedetomidine hydrochloride group (D group : 19 patients) and the propofol group (P group : 11 patients). We evaluated 3 points : 1) recall during tracheal intubation, 2) recall at extubation, and 3) postoperative discomfort. Statistical analysis was performed, using the Mann-Whitney test. Furthermore, the relationship between amnesia and relief of postoperative discomfort was analyzed in both groups, using a chi-square test. Results : the rate of recall during tracheal intubation in the P group was significantly less than that in the D group (p = 0.025), and the rate of recall at extubation in P group was also significantly less than that in D group (p = 0.047). According to postoperative discomfort, the rate of "very uncomfortable" or "uncomfortable feeling" in the P group was significantly lower than that in the D group (p = 0.003). There was a significant correlation between amnesia and relief of discomfort, and the patients with amnesia were relieved of postoperative discomfort. In conclusion, the present study indicated that compared to propofol, sedation with dexmedetomidine hydrochloride has poor effects on amnesia and relief of postoperative discomfort under tracheal intubation following oral and maxillofacial surgery. Furthermore, the results suggest that amnesia is an important factor for sedation to relieve postoperative uncomfortable feeling under tracheal intubation for oral and maxillofacial surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 197-201 |
| Number of pages | 5 |
| Journal | Journal of Japanese Dental Society of Anesthesiology |
| Volume | 35 |
| Issue number | 2 |
| Publication status | Published - 2007 |
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Keywords
- Amnesia
- Dexmedetomidine
- Propofol
- Questionnaire survey
- Sedation
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
A comparison between dexmedetomidine hydrochloride and propofol in sedation following oral and maxillofacial surgery. / Tomoyasu, Yumiko; Higuchi, Hitoshi; Yoshida, Keita; Watanabe, Yoshihisa; Hayashi, Yukiko; Kohjitani, Atsushi; Maeda, Shigeru; Miyawaki, Takuya; Shimada, Masahiko.
In: Journal of Japanese Dental Society of Anesthesiology, Vol. 35, No. 2, 2007, p. 197-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A comparison between dexmedetomidine hydrochloride and propofol in sedation following oral and maxillofacial surgery
AU - Tomoyasu, Yumiko
AU - Higuchi, Hitoshi
AU - Yoshida, Keita
AU - Watanabe, Yoshihisa
AU - Hayashi, Yukiko
AU - Kohjitani, Atsushi
AU - Maeda, Shigeru
AU - Miyawaki, Takuya
AU - Shimada, Masahiko
PY - 2007
Y1 - 2007
N2 - We studied 30 patients sedated with dexmedetomidine hydrochloride or propofol under tracheal intubation following oral and maxillofacial surgery at the dental operating room in Okayama University Hospital between November 2005 and August 2006. We compared the effects on amnesia and relief of postoperative discomfort between dexmedetomidine hydrochloride and propofol, analyzing questionnaires completed a week after surgery. Sedation was given to the patients at the sedation levels around a Ramsay Score of 3 or 4. The patients were divided into the dexmedetomidine hydrochloride group (D group : 19 patients) and the propofol group (P group : 11 patients). We evaluated 3 points : 1) recall during tracheal intubation, 2) recall at extubation, and 3) postoperative discomfort. Statistical analysis was performed, using the Mann-Whitney test. Furthermore, the relationship between amnesia and relief of postoperative discomfort was analyzed in both groups, using a chi-square test. Results : the rate of recall during tracheal intubation in the P group was significantly less than that in the D group (p = 0.025), and the rate of recall at extubation in P group was also significantly less than that in D group (p = 0.047). According to postoperative discomfort, the rate of "very uncomfortable" or "uncomfortable feeling" in the P group was significantly lower than that in the D group (p = 0.003). There was a significant correlation between amnesia and relief of discomfort, and the patients with amnesia were relieved of postoperative discomfort. In conclusion, the present study indicated that compared to propofol, sedation with dexmedetomidine hydrochloride has poor effects on amnesia and relief of postoperative discomfort under tracheal intubation following oral and maxillofacial surgery. Furthermore, the results suggest that amnesia is an important factor for sedation to relieve postoperative uncomfortable feeling under tracheal intubation for oral and maxillofacial surgery.
AB - We studied 30 patients sedated with dexmedetomidine hydrochloride or propofol under tracheal intubation following oral and maxillofacial surgery at the dental operating room in Okayama University Hospital between November 2005 and August 2006. We compared the effects on amnesia and relief of postoperative discomfort between dexmedetomidine hydrochloride and propofol, analyzing questionnaires completed a week after surgery. Sedation was given to the patients at the sedation levels around a Ramsay Score of 3 or 4. The patients were divided into the dexmedetomidine hydrochloride group (D group : 19 patients) and the propofol group (P group : 11 patients). We evaluated 3 points : 1) recall during tracheal intubation, 2) recall at extubation, and 3) postoperative discomfort. Statistical analysis was performed, using the Mann-Whitney test. Furthermore, the relationship between amnesia and relief of postoperative discomfort was analyzed in both groups, using a chi-square test. Results : the rate of recall during tracheal intubation in the P group was significantly less than that in the D group (p = 0.025), and the rate of recall at extubation in P group was also significantly less than that in D group (p = 0.047). According to postoperative discomfort, the rate of "very uncomfortable" or "uncomfortable feeling" in the P group was significantly lower than that in the D group (p = 0.003). There was a significant correlation between amnesia and relief of discomfort, and the patients with amnesia were relieved of postoperative discomfort. In conclusion, the present study indicated that compared to propofol, sedation with dexmedetomidine hydrochloride has poor effects on amnesia and relief of postoperative discomfort under tracheal intubation following oral and maxillofacial surgery. Furthermore, the results suggest that amnesia is an important factor for sedation to relieve postoperative uncomfortable feeling under tracheal intubation for oral and maxillofacial surgery.
KW - Amnesia
KW - Dexmedetomidine
KW - Propofol
KW - Questionnaire survey
KW - Sedation
UR - http://www.scopus.com/inward/record.url?scp=34248651565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248651565&partnerID=8YFLogxK
M3 - Article
VL - 35
SP - 197
EP - 201
JO - Journal of Japanese Dental Society of Anesthesiology
JF - Journal of Japanese Dental Society of Anesthesiology
SN - 0386-5835
IS - 2
ER -