A comparative study of cefozopran for chronic respiratory tract infections

Hiroyuki Kobayashi; Shin Kawai; Sokichi Onodera; Hitoshi Nakano; Tadakatsu Tsuji; Junichi Maruyama; Tetsuo Shimizu; Nobuhiro Sasaki; Shuji Yamaguchi; Yasuo Ohki; Yutaka Nishigaki; Akira Saito; Masumi Tomizawa; Yohmei Hiraga; Mitsuhide Ohmichi; Tsugio Terai; Takashi Yoshikawa; Yasuto Iida; Kazuyuki Kato; Hidenori Yashima; Kazuo Takebe; Mitsuo Masuda; Seiichi Murakami; Masakatsu Matsukawa; Ken Osonoi; Masashi Tamura; Kazuki Konishi; Kazuo Obara; Osamu Katagiri; Taiji Yoshida; Masao Sato; Tamotsu Takishima; Yasuo Tanno; Masakichi Motomiya; Akira Watanabe; Yutaka Tokue; Kazuo Sato; Shigeo Takizawa; Mikae Nakamura; Masaaki Arakawa; Kohichi Wada; Fumihide Iwata; Shigeyuki Hoshino; Hiroki Tsukata; Osamu Sekine; Yasutoshi Suzuki; Nobuki Aoki; Hazime Takeda; Osamu Sakai; Kohya Shiba; Kazuhisa Okada; Hisao Nakamura; Hiroichi Tanimoto; Kazuo Obara; Katsumi Komatsuzaki; Osamu Tanabe; Kaoru Shimada; Yasuyuki Sano; Yasuo Arai; Takashi Inamatsu; Masaru Koyama; Kohichiro Nakata; Kohji Narui; Izumi Hayashi; Hideo Ikemoto; Harumi Shishido; Hisashi Watanabe; Jingoro Shimada; Seiji Hori; Fumio Matsumoto; Takeo Imai; Shigeki Odagiri; Takashi Ogura; Midori Sumitomo; Yasuhiro Yoshiike; Yoshihiro Hirai; Eri Hagiwara; Takashi Sakuma; Shoichiro Irimajiri; Seiji Mita; Takao Okubo; Hirotada Ikeda; Yoshiki Murakoshi; Makoto Kudo; Kenji Tani; Tamotsu Kaneko; Toshio Nakamura; Toshiki Iwabuchi; Hideyuki Hasegawa; Masao Nakamura; Akira Shoji; Atsuhiko Sato; Kingo Chida; Shiro Imokawa; Hideki Suganuma; Ryoji Tamura; Takeshi Yagi; Masahiko Okano; Jinichiro Akiyama; Masami Taniguchi; Noriko Kita; Hirokazu Okano; Toshihiko Takeuchi; Yasuo Yamada; Toshinobu Yamamoto; Hidekazu Hanaki; Shinji Takeyama; Yoshimitsu Hayashi; Kazuhide Yamamoto; Hiromi Kato; Tadashi Kobayashi; Tatsuto Uno; Hidehiko Suzuki; Takateru Izumi; Koich Nishimura; Hiroshi Koyama; Naoki Fujimura; Kohei Hamamoto; Hitoshi Asamoto; Yoshihiro Ueda; Nobuhiro Narita; Masayoshi Sawaki; Keiichi Mikasa; Fumio Mikia; Takehiko Kobayashi; Rinzo Soejima; Yoshihito Niki; Masaru Sumi; Osamu Moriya; Toshiharu Matsushima; Makoto Kimura; Takao Sasaki; Yukio Matsumoto; Yuji Sugimoto; Michiro Yamakido; Kenji Hasegawa; Takeshi Isobe; Tohru Kurimura; Takahiko Hiramoto; Kohji Takeda; Mamoru Toyofuku; Yoshiro Sawae; Michio Fukuma; Shinji Nakajima; Takashi Ito; Koji Takaki; Kiyoshi Ninomiya; Yukiko Kumagai; Kotaro Ohizumi; Yoichiro Ichikawa; Naoto Tokunaga; Soichirou Ide; Masashi Kawahara; Hironari Shigematsu; Akira Nagata; Yumi Fukuda; Kazuma Fujino; Fumio Tanaka; Hiroaki Furuno; Yoshiyuki Mitsutake; Kozo Ishii; Kohei Hara; Shigeru Kohno; Hironobu Koga; Masato Yatsugi; Kazuo Sasayama; Naomi Ito; Kazuhiro Okuno; Kiyoyasu Fukushima; Akira Ishizaki; Koichi Watanabe; Tohru Ishino; Yuichi Inoue; Sadahiro Asai; Naofumi Suyama; Hideo Mashimoto; Keizo Matsumoto; Takeshi Nagatake; Atsushi Takahashi; Hidehiko Hirose; Yoshihiko Ikeda; Toshihiro Morito; Hiroyuki Yoshimine; Hiroshi Tanaka; Naoto Rikitomi; Tasuku Sakamoto; Masakazu Takasugi; Satoshi Degawa; Mikio Taguchi; Masashi Yamamoto; Kiyoshi Shima; Shinobu Takenaka; Nahomi Hirata; Shigeru Matsukura; Yasumasa Doutsu; Junichi Ashitani; Masaru Nasu; Tohru Yamazaki; Yoichiro Goto; Hiroyuki Nagai; Takayoshi Tashiro; Jun Goto; Kazuo Kitagawa; Saburo Urakami; Hiroshi Nagaoka; Atsushi Saito; Yoshiteru Shigeno; Yuei Irabu; Hiroshi Fukuhara; Nobuchika Kusano; Mitsuhiko Futenma; Daishiro Kitagawa; Mamoru Miyagi; Hiroshi Teruya; Nobuya Ogawa; Mitsuo Kaku; Kazuyuki Sugawara

doi:10.11250/chemotherapy1953.41.989

A comparative study of cefozopran for chronic respiratory tract infections

Hiroyuki Kobayashi, Shin Kawai, Sokichi Onodera, Hitoshi Nakano, Tadakatsu Tsuji, Junichi Maruyama, Tetsuo Shimizu, Nobuhiro Sasaki, Shuji Yamaguchi, Yasuo Ohki, Yutaka Nishigaki, Akira Saito, Masumi Tomizawa, Yohmei Hiraga, Mitsuhide Ohmichi, Tsugio Terai, Takashi Yoshikawa, Yasuto Iida, Kazuyuki Kato, Hidenori YashimaKazuo Takebe, Mitsuo Masuda, Seiichi Murakami, Masakatsu Matsukawa, Ken Osonoi, Masashi Tamura, Kazuki Konishi, Kazuo Obara, Osamu Katagiri, Taiji Yoshida, Masao Sato, Tamotsu Takishima, Yasuo Tanno, Masakichi Motomiya, Akira Watanabe, Yutaka Tokue, Kazuo Sato, Shigeo Takizawa, Mikae Nakamura, Masaaki Arakawa, Kohichi Wada, Fumihide Iwata, Shigeyuki Hoshino, Hiroki Tsukata, Osamu Sekine, Yasutoshi Suzuki, Nobuki Aoki, Hazime Takeda, Osamu Sakai, Kohya Shiba, Kazuhisa Okada, Hisao Nakamura, Hiroichi Tanimoto, Kazuo Obara, Katsumi Komatsuzaki, Osamu Tanabe, Kaoru Shimada, Yasuyuki Sano, Yasuo Arai, Takashi Inamatsu, Masaru Koyama, Kohichiro Nakata, Kohji Narui, Izumi Hayashi, Hideo Ikemoto, Harumi Shishido, Hisashi Watanabe, Jingoro Shimada, Seiji Hori, Fumio Matsumoto, Takeo Imai, Shigeki Odagiri, Takashi Ogura, Midori Sumitomo, Yasuhiro Yoshiike, Yoshihiro Hirai, Eri Hagiwara, Takashi Sakuma, Shoichiro Irimajiri, Seiji Mita, Takao Okubo, Hirotada Ikeda, Yoshiki Murakoshi, Makoto Kudo, Kenji Tani, Tamotsu Kaneko, Toshio Nakamura, Toshiki Iwabuchi, Hideyuki Hasegawa, Masao Nakamura, Akira Shoji, Atsuhiko Sato, Kingo Chida, Shiro Imokawa, Hideki Suganuma, Ryoji Tamura, Takeshi Yagi, Masahiko Okano, Jinichiro Akiyama, Masami Taniguchi, Noriko Kita, Hirokazu Okano, Toshihiko Takeuchi, Yasuo Yamada, Toshinobu Yamamoto, Hidekazu Hanaki, Shinji Takeyama, Yoshimitsu Hayashi, Kazuhide Yamamoto, Hiromi Kato, Tadashi Kobayashi, Tatsuto Uno, Hidehiko Suzuki, Takateru Izumi, Koich Nishimura, Hiroshi Koyama, Naoki Fujimura, Kohei Hamamoto, Hitoshi Asamoto, Yoshihiro Ueda, Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Fumio Mikia, Takehiko Kobayashi, Rinzo Soejima, Yoshihito Niki, Masaru Sumi, Osamu Moriya, Toshiharu Matsushima, Makoto Kimura, Takao Sasaki, Yukio Matsumoto, Yuji Sugimoto, Michiro Yamakido, Kenji Hasegawa, Takeshi Isobe, Tohru Kurimura, Takahiko Hiramoto, Kohji Takeda, Mamoru Toyofuku, Yoshiro Sawae, Michio Fukuma, Shinji Nakajima, Takashi Ito, Koji Takaki, Kiyoshi Ninomiya, Yukiko Kumagai, Kotaro Ohizumi, Yoichiro Ichikawa, Naoto Tokunaga, Soichirou Ide, Masashi Kawahara, Hironari Shigematsu, Akira Nagata, Yumi Fukuda, Kazuma Fujino, Fumio Tanaka, Hiroaki Furuno, Yoshiyuki Mitsutake, Kozo Ishii, Kohei Hara, Shigeru Kohno, Hironobu Koga, Masato Yatsugi, Kazuo Sasayama, Naomi Ito, Kazuhiro Okuno, Kiyoyasu Fukushima, Akira Ishizaki, Koichi Watanabe, Tohru Ishino, Yuichi Inoue, Sadahiro Asai, Naofumi Suyama, Hideo Mashimoto, Keizo Matsumoto, Takeshi Nagatake, Atsushi Takahashi, Hidehiko Hirose, Yoshihiko Ikeda, Toshihiro Morito, Hiroyuki Yoshimine, Hiroshi Tanaka, Naoto Rikitomi, Tasuku Sakamoto, Masakazu Takasugi, Satoshi Degawa, Mikio Taguchi, Masashi Yamamoto, Kiyoshi Shima, Shinobu Takenaka, Nahomi Hirata, Shigeru Matsukura, Yasumasa Doutsu, Junichi Ashitani, Masaru Nasu, Tohru Yamazaki, Yoichiro Goto, Hiroyuki Nagai, Takayoshi Tashiro, Jun Goto, Kazuo Kitagawa, Saburo Urakami, Hiroshi Nagaoka, Atsushi Saito, Yoshiteru Shigeno, Yuei Irabu, Hiroshi Fukuhara, Nobuchika Kusano, Mitsuhiko Futenma, Daishiro Kitagawa, Mamoru Miyagi, Hiroshi Teruya, Nobuya Ogawa, Mitsuo Kaku, Kazuyuki Sugawara

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The clinical efficacy, safety and utility of cefozopran (CZOP), a new eephem antibiotic, were evaluated in chronic respiratory infections in a comparative study versus ceftazidime (CAZ), Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days, and the forllowing results were obtained: 1. A total of 264 patients were enrolled in this study. Efficacy rates (“good” or better responses) were 91.0% (101/111) in the CZOP group and 88.3% (106/120) in the CAZ group, with no significant difference between the two groups. 2. Bacteriologically, eradication rates were 91.5% (65/71) in the CZOP group and 85.3% (64/ 75) in the CAZ group, with no significant difference between the two groups. 3. Adverse reactions occurred in 8 of the 122 patients in the CZOP group and in 3 of the 126 patients in the CAZ group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 27.7% (33/119) in the CZOP group and 19.8% (25/ 126) in the CAZ group with no significant difference between the two groups. 4. The usefulness rates (“useful” or better evaluations) were 87.6% (99/113) in the CZOP group and 86.0% (104/121) in the CAZ group, with no significant difference between the two groups. No significant differences were observed between the two groups with respect to any of the above parameters. These results indicate that CZOP is useful for the treatment of chronic respiratory tract infections.

Original language	English
Pages (from-to)	989-1017
Number of pages	29
Journal	CHEMOTHERAPY
Volume	41
Issue number	9
DOIs	https://doi.org/10.11250/chemotherapy1953.41.989
Publication status	Published - 1993
Externally published	Yes

Keywords

cefozopran
ceftazidime
chronic respiratory tract infection
comparative study

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.11250/chemotherapy1953.41.989

Cite this

Kobayashi, H., Kawai, S., Onodera, S., Nakano, H., Tsuji, T., Maruyama, J., Shimizu, T., Sasaki, N., Yamaguchi, S., Ohki, Y., Nishigaki, Y., Saito, A., Tomizawa, M., Hiraga, Y., Ohmichi, M., Terai, T., Yoshikawa, T., Iida, Y., Kato, K., ... Sugawara, K. (1993). A comparative study of cefozopran for chronic respiratory tract infections. CHEMOTHERAPY, 41(9), 989-1017. https://doi.org/10.11250/chemotherapy1953.41.989

Kobayashi, H, Kawai, S, Onodera, S, Nakano, H, Tsuji, T, Maruyama, J, Shimizu, T, Sasaki, N, Yamaguchi, S, Ohki, Y, Nishigaki, Y, Saito, A, Tomizawa, M, Hiraga, Y, Ohmichi, M, Terai, T, Yoshikawa, T, Iida, Y, Kato, K, Yashima, H, Takebe, K, Masuda, M, Murakami, S, Matsukawa, M, Osonoi, K, Tamura, M, Konishi, K, Obara, K, Katagiri, O, Yoshida, T, Sato, M, Takishima, T, Tanno, Y, Motomiya, M, Watanabe, A, Tokue, Y, Sato, K, Takizawa, S, Nakamura, M, Arakawa, M, Wada, K, Iwata, F, Hoshino, S, Tsukata, H, Sekine, O, Suzuki, Y, Aoki, N, Takeda, H, Sakai, O, Shiba, K, Okada, K, Nakamura, H, Tanimoto, H, Obara, K, Komatsuzaki, K, Tanabe, O, Shimada, K, Sano, Y, Arai, Y, Inamatsu, T, Koyama, M, Nakata, K, Narui, K, Hayashi, I, Ikemoto, H, Shishido, H, Watanabe, H, Shimada, J, Hori, S, Matsumoto, F, Imai, T, Odagiri, S, Ogura, T, Sumitomo, M, Yoshiike, Y, Hirai, Y, Hagiwara, E, Sakuma, T, Irimajiri, S, Mita, S, Okubo, T, Ikeda, H, Murakoshi, Y, Kudo, M, Tani, K, Kaneko, T, Nakamura, T, Iwabuchi, T, Hasegawa, H, Nakamura, M, Shoji, A, Sato, A, Chida, K, Imokawa, S, Suganuma, H, Tamura, R, Yagi, T, Okano, M, Akiyama, J, Taniguchi, M, Kita, N, Okano, H, Takeuchi, T, Yamada, Y, Yamamoto, T, Hanaki, H, Takeyama, S, Hayashi, Y, Yamamoto, K, Kato, H, Kobayashi, T, Uno, T, Suzuki, H, Izumi, T, Nishimura, K, Koyama, H, Fujimura, N, Hamamoto, K, Asamoto, H, Ueda, Y, Narita, N, Sawaki, M, Mikasa, K, Mikia, F, Kobayashi, T, Soejima, R, Niki, Y, Sumi, M, Moriya, O, Matsushima, T, Kimura, M, Sasaki, T, Matsumoto, Y, Sugimoto, Y, Yamakido, M, Hasegawa, K, Isobe, T, Kurimura, T, Hiramoto, T, Takeda, K, Toyofuku, M, Sawae, Y, Fukuma, M, Nakajima, S, Ito, T, Takaki, K, Ninomiya, K, Kumagai, Y, Ohizumi, K, Ichikawa, Y, Tokunaga, N, Ide, S, Kawahara, M, Shigematsu, H, Nagata, A, Fukuda, Y, Fujino, K, Tanaka, F, Furuno, H, Mitsutake, Y, Ishii, K, Hara, K, Kohno, S, Koga, H, Yatsugi, M, Sasayama, K, Ito, N, Okuno, K, Fukushima, K, Ishizaki, A, Watanabe, K, Ishino, T, Inoue, Y, Asai, S, Suyama, N, Mashimoto, H, Matsumoto, K, Nagatake, T, Takahashi, A, Hirose, H, Ikeda, Y, Morito, T, Yoshimine, H, Tanaka, H, Rikitomi, N, Sakamoto, T, Takasugi, M, Degawa, S, Taguchi, M, Yamamoto, M, Shima, K, Takenaka, S, Hirata, N, Matsukura, S, Doutsu, Y, Ashitani, J, Nasu, M, Yamazaki, T, Goto, Y, Nagai, H, Tashiro, T, Goto, J, Kitagawa, K, Urakami, S, Nagaoka, H, Saito, A, Shigeno, Y, Irabu, Y, Fukuhara, H, Kusano, N, Futenma, M, Kitagawa, D, Miyagi, M, Teruya, H, Ogawa, N, Kaku, M & Sugawara, K 1993, 'A comparative study of cefozopran for chronic respiratory tract infections', CHEMOTHERAPY, vol. 41, no. 9, pp. 989-1017. https://doi.org/10.11250/chemotherapy1953.41.989

@article{c2c282ea83d74fc1b101ebef663eae4b,

title = "A comparative study of cefozopran for chronic respiratory tract infections",

abstract = "The clinical efficacy, safety and utility of cefozopran (CZOP), a new eephem antibiotic, were evaluated in chronic respiratory infections in a comparative study versus ceftazidime (CAZ), Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days, and the forllowing results were obtained: 1. A total of 264 patients were enrolled in this study. Efficacy rates (“good” or better responses) were 91.0% (101/111) in the CZOP group and 88.3% (106/120) in the CAZ group, with no significant difference between the two groups. 2. Bacteriologically, eradication rates were 91.5% (65/71) in the CZOP group and 85.3% (64/ 75) in the CAZ group, with no significant difference between the two groups. 3. Adverse reactions occurred in 8 of the 122 patients in the CZOP group and in 3 of the 126 patients in the CAZ group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 27.7% (33/119) in the CZOP group and 19.8% (25/ 126) in the CAZ group with no significant difference between the two groups. 4. The usefulness rates (“useful” or better evaluations) were 87.6% (99/113) in the CZOP group and 86.0% (104/121) in the CAZ group, with no significant difference between the two groups. No significant differences were observed between the two groups with respect to any of the above parameters. These results indicate that CZOP is useful for the treatment of chronic respiratory tract infections.",

keywords = "cefozopran, ceftazidime, chronic respiratory tract infection, comparative study",

author = "Hiroyuki Kobayashi and Shin Kawai and Sokichi Onodera and Hitoshi Nakano and Tadakatsu Tsuji and Junichi Maruyama and Tetsuo Shimizu and Nobuhiro Sasaki and Shuji Yamaguchi and Yasuo Ohki and Yutaka Nishigaki and Akira Saito and Masumi Tomizawa and Yohmei Hiraga and Mitsuhide Ohmichi and Tsugio Terai and Takashi Yoshikawa and Yasuto Iida and Kazuyuki Kato and Hidenori Yashima and Kazuo Takebe and Mitsuo Masuda and Seiichi Murakami and Masakatsu Matsukawa and Ken Osonoi and Masashi Tamura and Kazuki Konishi and Kazuo Obara and Osamu Katagiri and Taiji Yoshida and Masao Sato and Tamotsu Takishima and Yasuo Tanno and Masakichi Motomiya and Akira Watanabe and Yutaka Tokue and Kazuo Sato and Shigeo Takizawa and Mikae Nakamura and Masaaki Arakawa and Kohichi Wada and Fumihide Iwata and Shigeyuki Hoshino and Hiroki Tsukata and Osamu Sekine and Yasutoshi Suzuki and Nobuki Aoki and Hazime Takeda and Osamu Sakai and Kohya Shiba and Kazuhisa Okada and Hisao Nakamura and Hiroichi Tanimoto and Kazuo Obara and Katsumi Komatsuzaki and Osamu Tanabe and Kaoru Shimada and Yasuyuki Sano and Yasuo Arai and Takashi Inamatsu and Masaru Koyama and Kohichiro Nakata and Kohji Narui and Izumi Hayashi and Hideo Ikemoto and Harumi Shishido and Hisashi Watanabe and Jingoro Shimada and Seiji Hori and Fumio Matsumoto and Takeo Imai and Shigeki Odagiri and Takashi Ogura and Midori Sumitomo and Yasuhiro Yoshiike and Yoshihiro Hirai and Eri Hagiwara and Takashi Sakuma and Shoichiro Irimajiri and Seiji Mita and Takao Okubo and Hirotada Ikeda and Yoshiki Murakoshi and Makoto Kudo and Kenji Tani and Tamotsu Kaneko and Toshio Nakamura and Toshiki Iwabuchi and Hideyuki Hasegawa and Masao Nakamura and Akira Shoji and Atsuhiko Sato and Kingo Chida and Shiro Imokawa and Hideki Suganuma and Ryoji Tamura and Takeshi Yagi and Masahiko Okano and Jinichiro Akiyama and Masami Taniguchi and Noriko Kita and Hirokazu Okano and Toshihiko Takeuchi and Yasuo Yamada and Toshinobu Yamamoto and Hidekazu Hanaki and Shinji Takeyama and Yoshimitsu Hayashi and Kazuhide Yamamoto and Hiromi Kato and Tadashi Kobayashi and Tatsuto Uno and Hidehiko Suzuki and Takateru Izumi and Koich Nishimura and Hiroshi Koyama and Naoki Fujimura and Kohei Hamamoto and Hitoshi Asamoto and Yoshihiro Ueda and Nobuhiro Narita and Masayoshi Sawaki and Keiichi Mikasa and Fumio Mikia and Takehiko Kobayashi and Rinzo Soejima and Yoshihito Niki and Masaru Sumi and Osamu Moriya and Toshiharu Matsushima and Makoto Kimura and Takao Sasaki and Yukio Matsumoto and Yuji Sugimoto and Michiro Yamakido and Kenji Hasegawa and Takeshi Isobe and Tohru Kurimura and Takahiko Hiramoto and Kohji Takeda and Mamoru Toyofuku and Yoshiro Sawae and Michio Fukuma and Shinji Nakajima and Takashi Ito and Koji Takaki and Kiyoshi Ninomiya and Yukiko Kumagai and Kotaro Ohizumi and Yoichiro Ichikawa and Naoto Tokunaga and Soichirou Ide and Masashi Kawahara and Hironari Shigematsu and Akira Nagata and Yumi Fukuda and Kazuma Fujino and Fumio Tanaka and Hiroaki Furuno and Yoshiyuki Mitsutake and Kozo Ishii and Kohei Hara and Shigeru Kohno and Hironobu Koga and Masato Yatsugi and Kazuo Sasayama and Naomi Ito and Kazuhiro Okuno and Kiyoyasu Fukushima and Akira Ishizaki and Koichi Watanabe and Tohru Ishino and Yuichi Inoue and Sadahiro Asai and Naofumi Suyama and Hideo Mashimoto and Keizo Matsumoto and Takeshi Nagatake and Atsushi Takahashi and Hidehiko Hirose and Yoshihiko Ikeda and Toshihiro Morito and Hiroyuki Yoshimine and Hiroshi Tanaka and Naoto Rikitomi and Tasuku Sakamoto and Masakazu Takasugi and Satoshi Degawa and Mikio Taguchi and Masashi Yamamoto and Kiyoshi Shima and Shinobu Takenaka and Nahomi Hirata and Shigeru Matsukura and Yasumasa Doutsu and Junichi Ashitani and Masaru Nasu and Tohru Yamazaki and Yoichiro Goto and Hiroyuki Nagai and Takayoshi Tashiro and Jun Goto and Kazuo Kitagawa and Saburo Urakami and Hiroshi Nagaoka and Atsushi Saito and Yoshiteru Shigeno and Yuei Irabu and Hiroshi Fukuhara and Nobuchika Kusano and Mitsuhiko Futenma and Daishiro Kitagawa and Mamoru Miyagi and Hiroshi Teruya and Nobuya Ogawa and Mitsuo Kaku and Kazuyuki Sugawara",

year = "1993",

doi = "10.11250/chemotherapy1953.41.989",

language = "English",

volume = "41",

pages = "989--1017",

journal = "Chemotherapy",

issn = "0009-3165",

number = "9",

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T1 - A comparative study of cefozopran for chronic respiratory tract infections

AU - Kobayashi, Hiroyuki

AU - Kawai, Shin

AU - Onodera, Sokichi

AU - Nakano, Hitoshi

AU - Tsuji, Tadakatsu

AU - Maruyama, Junichi

AU - Shimizu, Tetsuo

AU - Sasaki, Nobuhiro

AU - Yamaguchi, Shuji

AU - Ohki, Yasuo

AU - Nishigaki, Yutaka

AU - Saito, Akira

AU - Tomizawa, Masumi

AU - Hiraga, Yohmei

AU - Ohmichi, Mitsuhide

AU - Terai, Tsugio

AU - Yoshikawa, Takashi

AU - Iida, Yasuto

AU - Kato, Kazuyuki

AU - Yashima, Hidenori

AU - Takebe, Kazuo

AU - Masuda, Mitsuo

AU - Murakami, Seiichi

AU - Matsukawa, Masakatsu

AU - Osonoi, Ken

AU - Tamura, Masashi

AU - Konishi, Kazuki

AU - Obara, Kazuo

AU - Katagiri, Osamu

AU - Yoshida, Taiji

AU - Sato, Masao

AU - Takishima, Tamotsu

AU - Tanno, Yasuo

AU - Motomiya, Masakichi

AU - Watanabe, Akira

AU - Tokue, Yutaka

AU - Sato, Kazuo

AU - Takizawa, Shigeo

AU - Nakamura, Mikae

AU - Arakawa, Masaaki

AU - Wada, Kohichi

AU - Iwata, Fumihide

AU - Hoshino, Shigeyuki

AU - Tsukata, Hiroki

AU - Sekine, Osamu

AU - Suzuki, Yasutoshi

AU - Aoki, Nobuki

AU - Takeda, Hazime

AU - Sakai, Osamu

AU - Shiba, Kohya

AU - Okada, Kazuhisa

AU - Nakamura, Hisao

AU - Tanimoto, Hiroichi

AU - Obara, Kazuo

AU - Komatsuzaki, Katsumi

AU - Tanabe, Osamu

AU - Shimada, Kaoru

AU - Sano, Yasuyuki

AU - Arai, Yasuo

AU - Inamatsu, Takashi

AU - Koyama, Masaru

AU - Nakata, Kohichiro

AU - Narui, Kohji

AU - Hayashi, Izumi

AU - Ikemoto, Hideo

AU - Shishido, Harumi

AU - Watanabe, Hisashi

AU - Shimada, Jingoro

AU - Hori, Seiji

AU - Matsumoto, Fumio

AU - Imai, Takeo

AU - Odagiri, Shigeki

AU - Ogura, Takashi

AU - Sumitomo, Midori

AU - Yoshiike, Yasuhiro

AU - Hirai, Yoshihiro

AU - Hagiwara, Eri

AU - Sakuma, Takashi

AU - Irimajiri, Shoichiro

AU - Mita, Seiji

AU - Okubo, Takao

AU - Ikeda, Hirotada

AU - Murakoshi, Yoshiki

AU - Kudo, Makoto

AU - Tani, Kenji

AU - Kaneko, Tamotsu

AU - Nakamura, Toshio

AU - Iwabuchi, Toshiki

AU - Hasegawa, Hideyuki

AU - Nakamura, Masao

AU - Shoji, Akira

AU - Sato, Atsuhiko

AU - Chida, Kingo

AU - Imokawa, Shiro

AU - Suganuma, Hideki

AU - Tamura, Ryoji

AU - Yagi, Takeshi

AU - Okano, Masahiko

AU - Akiyama, Jinichiro

AU - Taniguchi, Masami

AU - Kita, Noriko

AU - Okano, Hirokazu

AU - Takeuchi, Toshihiko

AU - Yamada, Yasuo

AU - Yamamoto, Toshinobu

AU - Hanaki, Hidekazu

AU - Takeyama, Shinji

AU - Hayashi, Yoshimitsu

AU - Yamamoto, Kazuhide

AU - Kato, Hiromi

AU - Kobayashi, Tadashi

AU - Uno, Tatsuto

AU - Suzuki, Hidehiko

AU - Izumi, Takateru

AU - Nishimura, Koich

AU - Koyama, Hiroshi

AU - Fujimura, Naoki

AU - Hamamoto, Kohei

AU - Asamoto, Hitoshi

AU - Ueda, Yoshihiro

AU - Narita, Nobuhiro

AU - Sawaki, Masayoshi

AU - Mikasa, Keiichi

AU - Mikia, Fumio

AU - Kobayashi, Takehiko

AU - Soejima, Rinzo

AU - Niki, Yoshihito

AU - Sumi, Masaru

AU - Moriya, Osamu

AU - Matsushima, Toshiharu

AU - Kimura, Makoto

AU - Sasaki, Takao

AU - Matsumoto, Yukio

AU - Sugimoto, Yuji

AU - Yamakido, Michiro

AU - Hasegawa, Kenji

AU - Isobe, Takeshi

AU - Kurimura, Tohru

AU - Hiramoto, Takahiko

AU - Takeda, Kohji

AU - Toyofuku, Mamoru

AU - Sawae, Yoshiro

AU - Fukuma, Michio

AU - Nakajima, Shinji

AU - Ito, Takashi

AU - Takaki, Koji

AU - Ninomiya, Kiyoshi

AU - Kumagai, Yukiko

AU - Ohizumi, Kotaro

AU - Ichikawa, Yoichiro

AU - Tokunaga, Naoto

AU - Ide, Soichirou

AU - Kawahara, Masashi

AU - Shigematsu, Hironari

AU - Nagata, Akira

AU - Fukuda, Yumi

AU - Fujino, Kazuma

AU - Tanaka, Fumio

AU - Furuno, Hiroaki

AU - Mitsutake, Yoshiyuki

AU - Ishii, Kozo

AU - Hara, Kohei

AU - Kohno, Shigeru

AU - Koga, Hironobu

AU - Yatsugi, Masato

AU - Sasayama, Kazuo

AU - Ito, Naomi

AU - Okuno, Kazuhiro

AU - Fukushima, Kiyoyasu

AU - Ishizaki, Akira

AU - Watanabe, Koichi

AU - Ishino, Tohru

AU - Inoue, Yuichi

AU - Asai, Sadahiro

AU - Suyama, Naofumi

AU - Mashimoto, Hideo

AU - Matsumoto, Keizo

AU - Nagatake, Takeshi

AU - Takahashi, Atsushi

AU - Hirose, Hidehiko

AU - Ikeda, Yoshihiko

AU - Morito, Toshihiro

AU - Yoshimine, Hiroyuki

AU - Tanaka, Hiroshi

AU - Rikitomi, Naoto

AU - Sakamoto, Tasuku

AU - Takasugi, Masakazu

AU - Degawa, Satoshi

AU - Taguchi, Mikio

AU - Yamamoto, Masashi

AU - Shima, Kiyoshi

AU - Takenaka, Shinobu

AU - Hirata, Nahomi

AU - Matsukura, Shigeru

AU - Doutsu, Yasumasa

AU - Ashitani, Junichi

AU - Nasu, Masaru

AU - Yamazaki, Tohru

AU - Goto, Yoichiro

AU - Nagai, Hiroyuki

AU - Tashiro, Takayoshi

AU - Goto, Jun

AU - Kitagawa, Kazuo

AU - Urakami, Saburo

AU - Nagaoka, Hiroshi

AU - Saito, Atsushi

AU - Shigeno, Yoshiteru

AU - Irabu, Yuei

AU - Fukuhara, Hiroshi

AU - Kusano, Nobuchika

AU - Futenma, Mitsuhiko

AU - Kitagawa, Daishiro

AU - Miyagi, Mamoru

AU - Teruya, Hiroshi

AU - Ogawa, Nobuya

AU - Kaku, Mitsuo

AU - Sugawara, Kazuyuki

PY - 1993

Y1 - 1993

N2 - The clinical efficacy, safety and utility of cefozopran (CZOP), a new eephem antibiotic, were evaluated in chronic respiratory infections in a comparative study versus ceftazidime (CAZ), Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days, and the forllowing results were obtained: 1. A total of 264 patients were enrolled in this study. Efficacy rates (“good” or better responses) were 91.0% (101/111) in the CZOP group and 88.3% (106/120) in the CAZ group, with no significant difference between the two groups. 2. Bacteriologically, eradication rates were 91.5% (65/71) in the CZOP group and 85.3% (64/ 75) in the CAZ group, with no significant difference between the two groups. 3. Adverse reactions occurred in 8 of the 122 patients in the CZOP group and in 3 of the 126 patients in the CAZ group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 27.7% (33/119) in the CZOP group and 19.8% (25/ 126) in the CAZ group with no significant difference between the two groups. 4. The usefulness rates (“useful” or better evaluations) were 87.6% (99/113) in the CZOP group and 86.0% (104/121) in the CAZ group, with no significant difference between the two groups. No significant differences were observed between the two groups with respect to any of the above parameters. These results indicate that CZOP is useful for the treatment of chronic respiratory tract infections.

AB - The clinical efficacy, safety and utility of cefozopran (CZOP), a new eephem antibiotic, were evaluated in chronic respiratory infections in a comparative study versus ceftazidime (CAZ), Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days, and the forllowing results were obtained: 1. A total of 264 patients were enrolled in this study. Efficacy rates (“good” or better responses) were 91.0% (101/111) in the CZOP group and 88.3% (106/120) in the CAZ group, with no significant difference between the two groups. 2. Bacteriologically, eradication rates were 91.5% (65/71) in the CZOP group and 85.3% (64/ 75) in the CAZ group, with no significant difference between the two groups. 3. Adverse reactions occurred in 8 of the 122 patients in the CZOP group and in 3 of the 126 patients in the CAZ group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 27.7% (33/119) in the CZOP group and 19.8% (25/ 126) in the CAZ group with no significant difference between the two groups. 4. The usefulness rates (“useful” or better evaluations) were 87.6% (99/113) in the CZOP group and 86.0% (104/121) in the CAZ group, with no significant difference between the two groups. No significant differences were observed between the two groups with respect to any of the above parameters. These results indicate that CZOP is useful for the treatment of chronic respiratory tract infections.

KW - cefozopran

KW - ceftazidime

KW - chronic respiratory tract infection

KW - comparative study

UR - http://www.scopus.com/inward/record.url?scp=0027453876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027453876&partnerID=8YFLogxK

U2 - 10.11250/chemotherapy1953.41.989

DO - 10.11250/chemotherapy1953.41.989

M3 - Article

AN - SCOPUS:0027453876

VL - 41

SP - 989

EP - 1017

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3165

IS - 9

ER -

A comparative study of cefozopran for chronic respiratory tract infections

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