Abstract
A comparative study has been conducted to determine the clinical efficacy, safety and utility of a new injectable cephem antibiotic cefozopran (CZOP) versus a control drug, ceftazidime (CAZ), for bacterial pneumonia. CZOP and CAZ were administered, in principle, by intravenous drip infusion at a dose of 1.0g (potency), twice daily for 14days, and the following results were obtained: 1. The efficacy rates for the total number of cases evaluated were 90.5% (95/105) in the CZOP group and 96.0% (97/101) in the CAZ group. 2. Bacteriological eradication rates were 94.3% (50/53) in the CZOP group and 97.6% (41/42) in the CAZ group. 3. Adverse reaction rates were 6.2% (7/113) in the CZOP group and 3.4% (4/117) in the CAZ group. Abnormal laboratory finding rates were 27.0% (30/111) in the CZOP group and 31.6% (37/ 117) in the CAZ group. 4. Usefulness rates were 87.6% (92/105) in the CZOP group and 91.2% (93/102) in the CAZ group. These results indicate that CZOP is useful for the treatment of bacterial pneumonia.
| Original language | English |
|---|---|
| Pages (from-to) | 963-988 |
| Number of pages | 26 |
| Journal | Chemotherapy |
| Volume | 41 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1993 |
| Externally published | Yes |
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Keywords
- bacterial pneumonia
- cefozopran, ceftazidime
- comparative study
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Drug Discovery
- Pharmacology (medical)
- Infectious Diseases
Cite this
A comparative study of cefozopran for bacterial pneumonia. / Kobayashi, Hiroyuki; Kawai, Shin; Onodera, Sokichi; Nakano, Hitoshi; Tsuji, Tadakatsu; Maruyama, Junichi; Shimizu, Tetsuo; Sasaki, Nobuhiro; Fujita, Yuka; Saitoa, Akira; Saitoa, Akira; Hiraga, Yohmei; Omichi, Mitsuhide; Takebe, Kazuo; Masuda, Mitsuo; Murakami, Seiichi; Matsukawa, Masakatsu; Nakahata, Hisashi; Osonoi, Ken; Saito, Miyoko; Tamura, Masashi; Konishi, Kazuki; Obara, Kazuo; Aoyama, Yoji; Sugawara, Kazushige; Abe, Kazuyasu; Katagiri, Osamu; Yoshida, Taiji; Yasuda, Yuko; Suzuki, Yasuyuki; Sato, Masao; Takishima, Tamotsu; Tanno, Yasuo; Motomiya, Masakichi; Watanabe, Akira; Tokue, Yutaka; Takizawa, Shigeo; Nakamura, Mikae; Arakawa, Masaaki; Wada, Koichi; Iwata, Fumihide; Hoshino, Shigeyuki; Sekine, Osamu; Suzuki, Yasutoshi; Aoki, Nobuki; Takeda, Hajime; Shimada, Kaoru; Oka, Shinichi; Sano, Yasuyuki; Tanaka, Yasuko; Sakai, Osamu; Shiba, Kohya; Okada, Kazuhisa; Tsuruoka, Akira; Sanjo, Junko; Tanimoto, Hiroichi; Ikemoto, Hideo; Obara, Kazuo; Komatsuzaki, Katsumi; Tanabe, Osamu; Ikemoto, Hideo; Koyama, Masaru; Nakata, Koichiro; Narui, Koji; Hayashi, Izumi; Shimada, Jingoro; Hori, Seiji; Okubo, Takao; Ikeda, Hirotada; Irimajiri, Shoichiro; Mita, Seiji; Sato, Atsuhiko; Chida, Kingo; Okano, Masahiko; Akiyama, Jinichiro; Taniguchi, Masami; Okano, Hirokazu; Ida, Masaaki; Takeuchi, Toshihiko; Yamada, Yasuo; Yamamoto, Toshinobu; Hanaki, Hidekazu; Tashiro, Tomonori; Takeyama, Shinji; Hayashi, Yoshimitsu; Itoh, Tsuyoshi; Yamamoto, Kazuhide; Yamamoto, Toshiyuki; Suzuki, Kanzo; Matsuura, Toru; Izumi, Takateru; Fujimura, Naoki; Imai, Hiroyuki; Hamamoto, Kohei; Hashimoto, Keiji; Asamoto, Hitoshi; Sasaki, Yoshiyuki; Tsutsumi, Tateo; Takeda, Yasushi; Ueda, Yoshihiro; Narita, Nobuhiro; Sawaki, Masayoshi; Mikasa, Keiichi; Miki, Fumio; Murata, Tetsuto; Soejima, Rinzo; Niki, Yoshihito; Sumi, Masaru; Moriya, Osamu; Matsushima, Toshiharu; Kimura, Makoto; Sasaki, Takao; Matsumoto, Yukio; Sugimoto, Yuji; Yamakido, Michiro; Hasegawa, Kenji; Murakami, Isao; Sawae, Yoshiro; Okada, Kaoru; Takaki, Koji; Ninomiya, Kiyoshi; Kumagaya, Yukio; Oizumi, Kotaro; Ichikawa, Yoichiro; Tokunaga, Naoto; Higuchi, Eiichi; Fujino, Kazuma; Araki, Ken; Mitsutake, Yoshiyuki; Higashi, Toshihiro; Ishii, Kozo; Maruoka, Hiroshi; Tanoue, Shoko; Kawahara, Masashi; Saisho, Masazumi; Shigematsu, Hironari; Kawaguchi, Shinzo; Tanaka, Fumio; Furuno, Hiroaki; Otsuka, Takaoki; Hara, Kohei; Kohno, Shigeru; Koga, Hironobu; Yatsugi, Masato; Kawano, Kenji; Nakano, Tadashi; Sasayama, Kazuo; Ito, Naomi; Sakito, Osamu; Okuno, Kazuhiro; Fukushima, Kiyoyasu; Ishizaki, Takeshi; Watanabe, Koichi; Ishino, Toru; Inoue, Yuichi; Otsubo, Takakazu; Asai, Sadahiro; Suyama, Naofumi; Mashimoto, Hideo; Matsumoto, Keizo; Nagatake, Takeshi; Takahashi, Atsushi; Ikeda, Yoshihiko; Morito, Toshihiro; Yoshimine, Hiroyuki; Tanaka, Hiroshi; Rikitomi, Naoto; Sakamoto, Tasuku; Taguchi, Mikio; Hirose, Hidehiko; Yamamoto, Masashi; Matsukura, Shigeru; Doutsu, Yasumasa; Ashitani, Junichi; Nasu, Masaru; Yamazaki, Tohru; Goto, Yoichiro; Goto, Jun; Kitagawa, Kazuo; Urakami, Saburo; Nagaoka, Hiroshi; Saito, Atsushi; Shigeno, Yoshiteru; Irabu, Yuei; Fukuhara, Hiroshi; Kusano, Nobuchika; Kitagawa, Daishiro; Miyagi, Mamoru; Oyakawa, Tominori; Gakiya, Izuru; Ogawa, Nobuya; Kaku, Mitsuo; Sugawara, Kazuyuki.
In: Chemotherapy, Vol. 41, No. 9, 1993, p. 963-988.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A comparative study of cefozopran for bacterial pneumonia
AU - Kobayashi, Hiroyuki
AU - Kawai, Shin
AU - Onodera, Sokichi
AU - Nakano, Hitoshi
AU - Tsuji, Tadakatsu
AU - Maruyama, Junichi
AU - Shimizu, Tetsuo
AU - Sasaki, Nobuhiro
AU - Fujita, Yuka
AU - Saitoa, Akira
AU - Saitoa, Akira
AU - Hiraga, Yohmei
AU - Omichi, Mitsuhide
AU - Takebe, Kazuo
AU - Masuda, Mitsuo
AU - Murakami, Seiichi
AU - Matsukawa, Masakatsu
AU - Nakahata, Hisashi
AU - Osonoi, Ken
AU - Saito, Miyoko
AU - Tamura, Masashi
AU - Konishi, Kazuki
AU - Obara, Kazuo
AU - Aoyama, Yoji
AU - Sugawara, Kazushige
AU - Abe, Kazuyasu
AU - Katagiri, Osamu
AU - Yoshida, Taiji
AU - Yasuda, Yuko
AU - Suzuki, Yasuyuki
AU - Sato, Masao
AU - Takishima, Tamotsu
AU - Tanno, Yasuo
AU - Motomiya, Masakichi
AU - Watanabe, Akira
AU - Tokue, Yutaka
AU - Takizawa, Shigeo
AU - Nakamura, Mikae
AU - Arakawa, Masaaki
AU - Wada, Koichi
AU - Iwata, Fumihide
AU - Hoshino, Shigeyuki
AU - Sekine, Osamu
AU - Suzuki, Yasutoshi
AU - Aoki, Nobuki
AU - Takeda, Hajime
AU - Shimada, Kaoru
AU - Oka, Shinichi
AU - Sano, Yasuyuki
AU - Tanaka, Yasuko
AU - Sakai, Osamu
AU - Shiba, Kohya
AU - Okada, Kazuhisa
AU - Tsuruoka, Akira
AU - Sanjo, Junko
AU - Tanimoto, Hiroichi
AU - Ikemoto, Hideo
AU - Obara, Kazuo
AU - Komatsuzaki, Katsumi
AU - Tanabe, Osamu
AU - Ikemoto, Hideo
AU - Koyama, Masaru
AU - Nakata, Koichiro
AU - Narui, Koji
AU - Hayashi, Izumi
AU - Shimada, Jingoro
AU - Hori, Seiji
AU - Okubo, Takao
AU - Ikeda, Hirotada
AU - Irimajiri, Shoichiro
AU - Mita, Seiji
AU - Sato, Atsuhiko
AU - Chida, Kingo
AU - Okano, Masahiko
AU - Akiyama, Jinichiro
AU - Taniguchi, Masami
AU - Okano, Hirokazu
AU - Ida, Masaaki
AU - Takeuchi, Toshihiko
AU - Yamada, Yasuo
AU - Yamamoto, Toshinobu
AU - Hanaki, Hidekazu
AU - Tashiro, Tomonori
AU - Takeyama, Shinji
AU - Hayashi, Yoshimitsu
AU - Itoh, Tsuyoshi
AU - Yamamoto, Kazuhide
AU - Yamamoto, Toshiyuki
AU - Suzuki, Kanzo
AU - Matsuura, Toru
AU - Izumi, Takateru
AU - Fujimura, Naoki
AU - Imai, Hiroyuki
AU - Hamamoto, Kohei
AU - Hashimoto, Keiji
AU - Asamoto, Hitoshi
AU - Sasaki, Yoshiyuki
AU - Tsutsumi, Tateo
AU - Takeda, Yasushi
AU - Ueda, Yoshihiro
AU - Narita, Nobuhiro
AU - Sawaki, Masayoshi
AU - Mikasa, Keiichi
AU - Miki, Fumio
AU - Murata, Tetsuto
AU - Soejima, Rinzo
AU - Niki, Yoshihito
AU - Sumi, Masaru
AU - Moriya, Osamu
AU - Matsushima, Toshiharu
AU - Kimura, Makoto
AU - Sasaki, Takao
AU - Matsumoto, Yukio
AU - Sugimoto, Yuji
AU - Yamakido, Michiro
AU - Hasegawa, Kenji
AU - Murakami, Isao
AU - Sawae, Yoshiro
AU - Okada, Kaoru
AU - Takaki, Koji
AU - Ninomiya, Kiyoshi
AU - Kumagaya, Yukio
AU - Oizumi, Kotaro
AU - Ichikawa, Yoichiro
AU - Tokunaga, Naoto
AU - Higuchi, Eiichi
AU - Fujino, Kazuma
AU - Araki, Ken
AU - Mitsutake, Yoshiyuki
AU - Higashi, Toshihiro
AU - Ishii, Kozo
AU - Maruoka, Hiroshi
AU - Tanoue, Shoko
AU - Kawahara, Masashi
AU - Saisho, Masazumi
AU - Shigematsu, Hironari
AU - Kawaguchi, Shinzo
AU - Tanaka, Fumio
AU - Furuno, Hiroaki
AU - Otsuka, Takaoki
AU - Hara, Kohei
AU - Kohno, Shigeru
AU - Koga, Hironobu
AU - Yatsugi, Masato
AU - Kawano, Kenji
AU - Nakano, Tadashi
AU - Sasayama, Kazuo
AU - Ito, Naomi
AU - Sakito, Osamu
AU - Okuno, Kazuhiro
AU - Fukushima, Kiyoyasu
AU - Ishizaki, Takeshi
AU - Watanabe, Koichi
AU - Ishino, Toru
AU - Inoue, Yuichi
AU - Otsubo, Takakazu
AU - Asai, Sadahiro
AU - Suyama, Naofumi
AU - Mashimoto, Hideo
AU - Matsumoto, Keizo
AU - Nagatake, Takeshi
AU - Takahashi, Atsushi
AU - Ikeda, Yoshihiko
AU - Morito, Toshihiro
AU - Yoshimine, Hiroyuki
AU - Tanaka, Hiroshi
AU - Rikitomi, Naoto
AU - Sakamoto, Tasuku
AU - Taguchi, Mikio
AU - Hirose, Hidehiko
AU - Yamamoto, Masashi
AU - Matsukura, Shigeru
AU - Doutsu, Yasumasa
AU - Ashitani, Junichi
AU - Nasu, Masaru
AU - Yamazaki, Tohru
AU - Goto, Yoichiro
AU - Goto, Jun
AU - Kitagawa, Kazuo
AU - Urakami, Saburo
AU - Nagaoka, Hiroshi
AU - Saito, Atsushi
AU - Shigeno, Yoshiteru
AU - Irabu, Yuei
AU - Fukuhara, Hiroshi
AU - Kusano, Nobuchika
AU - Kitagawa, Daishiro
AU - Miyagi, Mamoru
AU - Oyakawa, Tominori
AU - Gakiya, Izuru
AU - Ogawa, Nobuya
AU - Kaku, Mitsuo
AU - Sugawara, Kazuyuki
PY - 1993
Y1 - 1993
N2 - A comparative study has been conducted to determine the clinical efficacy, safety and utility of a new injectable cephem antibiotic cefozopran (CZOP) versus a control drug, ceftazidime (CAZ), for bacterial pneumonia. CZOP and CAZ were administered, in principle, by intravenous drip infusion at a dose of 1.0g (potency), twice daily for 14days, and the following results were obtained: 1. The efficacy rates for the total number of cases evaluated were 90.5% (95/105) in the CZOP group and 96.0% (97/101) in the CAZ group. 2. Bacteriological eradication rates were 94.3% (50/53) in the CZOP group and 97.6% (41/42) in the CAZ group. 3. Adverse reaction rates were 6.2% (7/113) in the CZOP group and 3.4% (4/117) in the CAZ group. Abnormal laboratory finding rates were 27.0% (30/111) in the CZOP group and 31.6% (37/ 117) in the CAZ group. 4. Usefulness rates were 87.6% (92/105) in the CZOP group and 91.2% (93/102) in the CAZ group. These results indicate that CZOP is useful for the treatment of bacterial pneumonia.
AB - A comparative study has been conducted to determine the clinical efficacy, safety and utility of a new injectable cephem antibiotic cefozopran (CZOP) versus a control drug, ceftazidime (CAZ), for bacterial pneumonia. CZOP and CAZ were administered, in principle, by intravenous drip infusion at a dose of 1.0g (potency), twice daily for 14days, and the following results were obtained: 1. The efficacy rates for the total number of cases evaluated were 90.5% (95/105) in the CZOP group and 96.0% (97/101) in the CAZ group. 2. Bacteriological eradication rates were 94.3% (50/53) in the CZOP group and 97.6% (41/42) in the CAZ group. 3. Adverse reaction rates were 6.2% (7/113) in the CZOP group and 3.4% (4/117) in the CAZ group. Abnormal laboratory finding rates were 27.0% (30/111) in the CZOP group and 31.6% (37/ 117) in the CAZ group. 4. Usefulness rates were 87.6% (92/105) in the CZOP group and 91.2% (93/102) in the CAZ group. These results indicate that CZOP is useful for the treatment of bacterial pneumonia.
KW - bacterial pneumonia
KW - cefozopran, ceftazidime
KW - comparative study
UR - http://www.scopus.com/inward/record.url?scp=0027433403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027433403&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1953.41.963
DO - 10.11250/chemotherapy1953.41.963
M3 - Article
AN - SCOPUS:0027433403
VL - 41
SP - 963
EP - 988
JO - Chemotherapy
JF - Chemotherapy
SN - 0009-3165
IS - 9
ER -