Abstract
A comparative study has been conducted to determine the clinical efficacy, safety and utility of a new injectable cephem antibiotic cefozopran (CZOP) versus a control drug, ceftazidime (CAZ), for bacterial pneumonia. CZOP and CAZ were administered, in principle, by intravenous drip infusion at a dose of 1.0g (potency), twice daily for 14days, and the following results were obtained: 1. The efficacy rates for the total number of cases evaluated were 90.5% (95/105) in the CZOP group and 96.0% (97/101) in the CAZ group. 2. Bacteriological eradication rates were 94.3% (50/53) in the CZOP group and 97.6% (41/42) in the CAZ group. 3. Adverse reaction rates were 6.2% (7/113) in the CZOP group and 3.4% (4/117) in the CAZ group. Abnormal laboratory finding rates were 27.0% (30/111) in the CZOP group and 31.6% (37/ 117) in the CAZ group. 4. Usefulness rates were 87.6% (92/105) in the CZOP group and 91.2% (93/102) in the CAZ group. These results indicate that CZOP is useful for the treatment of bacterial pneumonia.
Original language | English |
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Pages (from-to) | 963-988 |
Number of pages | 26 |
Journal | CHEMOTHERAPY |
Volume | 41 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1993 |
Externally published | Yes |
Keywords
- bacterial pneumonia
- cefozopran, ceftazidime
- comparative study
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Drug Discovery
- Oncology