A comparative study of biapenem and imipenem/cilastatin for bacterial pneumonia

Fumio Matsumoto, Takeo Imai, Iwao Sakurai, Akira Saito, Masumi Tomizawa, Shosaku Abe, Yasuhito Honda, Kyuichiro Sekine, Tomofumi Igarashi, Sumio Imai, Hideaki Watanabe, Yuji Inoue, Kazuo Takebe, Toyokazu Tamura, Mitsuo Masuda, Masashi Tamura, Kazuki Konishi, Tokashi Mouri, Yukio Tanifuji, Kenichi TakeuchiHaruto Hirano, Kunio Shirato, Yasuo Tanno, Masahiro Sakamoto, Toshihiro Nukiwa, Akira Watanabe, Kiyoshi Konno, Tsuneo Sayama, Satoru Shoji, Kosaku Nagai, Kazunao Niizuma, Yusi Nakai, Yoshihiro Honda, Mitsunobu Honma, Kazuo Sato, Masaaki Arakawa, Koichi Wada, Hiroki Tsukada, Shigeyuki Hoshino, Humihide Iwata, Nobuki Aoki, Osamu Sekine, Yasutoshi Suzuki, Hajimu Takeda, Masataka Katsu, Noboru Aosaki, Morio Nakamura, Kaoru Shimada, Yasuyuki Sano, Norihisa Akiyama, Yasuo Arai, Yasuko Tanaka, Osamu Sakai, Kohya Shiba, Masaki Yoshida, Kazuhisa Okada, Hiroichi Tanimoto, Kazuo Obara, Katsumi Komatsuzaki, Osamu Tanabe, Hideo Nagamura, Ayumu Shimizu, Taichi Mochizuki, Takeshi Mori, Hiroshi Isonuma, Mayumi Takahashi, Kohichiro Nakata, Kohji Narui, Kohichiro Kudo, Noriko Tanabe, Izumi Hayashi, Otohiko Kunii, Hazime Nishiya, Yasuo Ono, Morimichi Yamaguchi, Hazime Sugiyama, Yoshio Uzuka, Harumi Shishido, Motoo Baba, Hiroyuki Kobayashi, Hiroaki Takeda, Tohru Sakayori, Hiroshi Miura, Hiroshi Oshitani, Masahiko Yoshida, Takao Ohkubo, Hirotada Ikeda, Kenji Tani, Tamotsu Kaneko, Jun Chiba, Toshio Nakamura, Hideyuki Hasegawa, Hiroshi Sakamoto, Jingoro Shimada, Seiji Hori, Shigeki Odagiri, Kaneo Suzuki, Midori Sumitomo, Taizi Amano, Yoshihiro Hirai, Eri Hagiwara, Shoichiro Irimaziri, Yasuo Matsuoka, Mitsuo Obana, Atsuhiko Sato, Kingo Chida, Ryoji Tamura, Takahumi Suda, Takeshi Yagi, Mikio Toyoshima, Masahiro Shirai, Masami Taniguchi, Kazuo Yasuda, Hiroshi Uchiyama, Yutaka Nakano, Kaoru Shimokata, Satoshi Ichiyama, Shuzo Sakai, Hironobu Minami, Masashi Yamamoto, Tetsuya Yagi, Kazuo Nakanishi, Katsuhisa Suda, Tohru Hara, Tetsusuke Yoshimoto, Toshiyuki Yamamoto, Kanzo Suzuki, Tohru Matsuura, Masahiro Yamakoshi, Toshihiko Takeuchi, Yasuo Yamada, Toshinobu Yamamoto, Atsushi Nakamura, Hidekazu Hanaki, Shinji Takeyama, Makoto Kawakami, Kazuhide Yamamoto, Ikuji Usami, Hideaki Kuroki, Fumio Miki, Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Mitsuru Konishi, Rinzo Soejima, Yoshihito Niki, Osamu Moriya, Toshiharu Matsushima, Makoto Kimura, Michiro Yamakido, Kenji Hasegawa, Naoki Yamaoka, Teruomi Miyazawa, Masao Doi, Kenichi Arita, Kazuhiro Daido, Takeshi Ejima, Osamu Kurimura, Masahiko Hiramoto, Naoko Tominaga, Kazumasa Saigo, Takao Sasaki, Yukio Matsumoto, Yuji Sugimoto, Tatsuya Konishi, Yoshiro Sawae, Kaoru Okada, Koji Takaki, Kiyoshi Ninomiya, Yukio Kumagai, Ikuo Sumita, Takanori Terashima, Hiroyasu Misumi, Nobuyuki Shimono, Masashi Takamoto, Toshikazu Yoshimura, Yasuko Harada, Susumu Harada, Tsuneo Ishibashi, Kikuo Arakawa, Kenji Kono, Kotaro Ohizumi, Yoichiro Ichikawa, Naoto Tokunaga, Tsuneaki Shiraishi, Masako Tanaka, Masao Kawahara, Masazumi Saisho, Shinzo Kawaguchi, Hironari Shigematsu, Yoshiyuki Mitsutake, Humio Tanaka, Kohei Hara, Shigeru Kohno, Hironobu Koga, Mitsuo Kaku, Kazunori Tomono, Kazuhiro Okuno, Kiyoyasu Fukushima, Yuichi Inoue, Naohumi Suyama, Masao Nakatomi, Miyako Ishiguro, Hideaki Sawa, Keizo Matsumoto, Tsuyoshi Nagatake, Yoshiaki Utsunomiya, Misao Tao, Masakazu Takasugi, Satoshi Degawa, Toshihiro Morito, Tasuku Sakamoto, Masaru Nasu, Yoichiro Goto, Tohru Yamasaki, Jun Goto, Kazuo Kitagawa, Masayuki Ando, Moritaka Suga, Hisato Yamazaki, Yoichiro Tsunoda, Sunako Kai, Atsushi Urata, Yasutsugu Fukuda, Katsumasa Tokunaga, Kiyoshi Shima, Shinobu Takenaka, Atsushi Saito, Hiroshi Fukuhara, Jun Inadome, Hiroaki Nakamura, Hiroshi Kaneshima, Isoko Ohwan, Nobuchika Kusano, Masakiyo Ishikawa, Akiko Miyasato, Mitsuyoshi Nakashima, Keizo Yamaguchi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The clinical efficacy, safety and usefulness of biapenem (BIPM), a new carbapenem antibiotic for injection, were evaluated in bacterial pneumonia in a comparative study with imipenem/cilastatin (IPM/CS). Patients were given 600 mg (potency) of BIPM or 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) for 14 days, and the following results were obtained: 1. A total of 183 cases were enrolled in this study, and 146 cases were evaluated for clinical efficacy. Efficacy rates were 94.8% (73/77) in the BIPM group and 92.8% (64/69) in the IPM/CS group, with no significant difference between the two groups. 2. Bacteriological eradication rates were 90.9% (20/22) in the BIPM group and 93.1% (27/29) in the IPM/CS group, with no significant difference between the two groups. 3. The incidence of adverse reaction was 3.4% (2/89) in the BIPM group and 3.6% (3/83) in the IPM/CS group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 29.5% (26/88) in the BIPM group and 25.6% (20/78) in the IPM/CS group. There was no significant difference between the two groups. 4. The usefulness rates were 94.8% (73/77) in the BIPM group and 88.6% (62/70) in the IPM/CS group. There was no significant difference between the two groups. No significant differences were observed between 600 mg (potency) of BIPM and 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) with respect to any of the above parameters. These results indicate that BIPM is useful for the treatment of bacterial pneumonia and lung abscess.

Original languageEnglish
Pages (from-to)41-62
Number of pages22
JournalJapanese Journal of Chemotherapy
Volume43
Issue number1
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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