Abstract
The clinical efficacy, safety and usefulness of biapenem (BIPM), a new carbapenem antibiotic for injection, were evaluated in bacterial pneumonia in a comparative study with imipenem/cilastatin (IPM/CS). Patients were given 600 mg (potency) of BIPM or 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) for 14 days, and the following results were obtained: 1. A total of 183 cases were enrolled in this study, and 146 cases were evaluated for clinical efficacy. Efficacy rates were 94.8% (73/77) in the BIPM group and 92.8% (64/69) in the IPM/CS group, with no significant difference between the two groups. 2. Bacteriological eradication rates were 90.9% (20/22) in the BIPM group and 93.1% (27/29) in the IPM/CS group, with no significant difference between the two groups. 3. The incidence of adverse reaction was 3.4% (2/89) in the BIPM group and 3.6% (3/83) in the IPM/CS group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 29.5% (26/88) in the BIPM group and 25.6% (20/78) in the IPM/CS group. There was no significant difference between the two groups. 4. The usefulness rates were 94.8% (73/77) in the BIPM group and 88.6% (62/70) in the IPM/CS group. There was no significant difference between the two groups. No significant differences were observed between 600 mg (potency) of BIPM and 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) with respect to any of the above parameters. These results indicate that BIPM is useful for the treatment of bacterial pneumonia and lung abscess.
Original language | English |
---|---|
Pages (from-to) | 41-62 |
Number of pages | 22 |
Journal | Japanese Journal of Chemotherapy |
Volume | 43 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1995 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
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A comparative study of biapenem and imipenem/cilastatin for bacterial pneumonia. / Matsumoto, Fumio; Imai, Takeo; Sakurai, Iwao; Saito, Akira; Tomizawa, Masumi; Abe, Shosaku; Honda, Yasuhito; Sekine, Kyuichiro; Igarashi, Tomofumi; Imai, Sumio; Watanabe, Hideaki; Inoue, Yuji; Takebe, Kazuo; Tamura, Toyokazu; Masuda, Mitsuo; Tamura, Masashi; Konishi, Kazuki; Mouri, Tokashi; Tanifuji, Yukio; Takeuchi, Kenichi; Hirano, Haruto; Shirato, Kunio; Tanno, Yasuo; Sakamoto, Masahiro; Nukiwa, Toshihiro; Watanabe, Akira; Konno, Kiyoshi; Sayama, Tsuneo; Shoji, Satoru; Nagai, Kosaku; Niizuma, Kazunao; Nakai, Yusi; Honda, Yoshihiro; Honma, Mitsunobu; Sato, Kazuo; Arakawa, Masaaki; Wada, Koichi; Tsukada, Hiroki; Hoshino, Shigeyuki; Iwata, Humihide; Aoki, Nobuki; Sekine, Osamu; Suzuki, Yasutoshi; Takeda, Hajimu; Katsu, Masataka; Aosaki, Noboru; Nakamura, Morio; Shimada, Kaoru; Sano, Yasuyuki; Akiyama, Norihisa; Arai, Yasuo; Tanaka, Yasuko; Sakai, Osamu; Shiba, Kohya; Yoshida, Masaki; Okada, Kazuhisa; Tanimoto, Hiroichi; Obara, Kazuo; Komatsuzaki, Katsumi; Tanabe, Osamu; Nagamura, Hideo; Shimizu, Ayumu; Mochizuki, Taichi; Mori, Takeshi; Isonuma, Hiroshi; Takahashi, Mayumi; Nakata, Kohichiro; Narui, Kohji; Kudo, Kohichiro; Tanabe, Noriko; Hayashi, Izumi; Kunii, Otohiko; Nishiya, Hazime; Ono, Yasuo; Yamaguchi, Morimichi; Sugiyama, Hazime; Uzuka, Yoshio; Shishido, Harumi; Baba, Motoo; Kobayashi, Hiroyuki; Takeda, Hiroaki; Sakayori, Tohru; Miura, Hiroshi; Oshitani, Hiroshi; Yoshida, Masahiko; Ohkubo, Takao; Ikeda, Hirotada; Tani, Kenji; Kaneko, Tamotsu; Chiba, Jun; Nakamura, Toshio; Hasegawa, Hideyuki; Sakamoto, Hiroshi; Shimada, Jingoro; Hori, Seiji; Odagiri, Shigeki; Suzuki, Kaneo; Sumitomo, Midori; Amano, Taizi; Hirai, Yoshihiro; Hagiwara, Eri; Irimaziri, Shoichiro; Matsuoka, Yasuo; Obana, Mitsuo; Sato, Atsuhiko; Chida, Kingo; Tamura, Ryoji; Suda, Takahumi; Yagi, Takeshi; Toyoshima, Mikio; Shirai, Masahiro; Taniguchi, Masami; Yasuda, Kazuo; Uchiyama, Hiroshi; Nakano, Yutaka; Shimokata, Kaoru; Ichiyama, Satoshi; Sakai, Shuzo; Minami, Hironobu; Yamamoto, Masashi; Yagi, Tetsuya; Nakanishi, Kazuo; Suda, Katsuhisa; Hara, Tohru; Yoshimoto, Tetsusuke; Yamamoto, Toshiyuki; Suzuki, Kanzo; Matsuura, Tohru; Yamakoshi, Masahiro; Takeuchi, Toshihiko; Yamada, Yasuo; Yamamoto, Toshinobu; Nakamura, Atsushi; Hanaki, Hidekazu; Takeyama, Shinji; Kawakami, Makoto; Yamamoto, Kazuhide; Usami, Ikuji; Kuroki, Hideaki; Miki, Fumio; Narita, Nobuhiro; Sawaki, Masayoshi; Mikasa, Keiichi; Konishi, Mitsuru; Soejima, Rinzo; Niki, Yoshihito; Moriya, Osamu; Matsushima, Toshiharu; Kimura, Makoto; Yamakido, Michiro; Hasegawa, Kenji; Yamaoka, Naoki; Miyazawa, Teruomi; Doi, Masao; Arita, Kenichi; Daido, Kazuhiro; Ejima, Takeshi; Kurimura, Osamu; Hiramoto, Masahiko; Tominaga, Naoko; Saigo, Kazumasa; Sasaki, Takao; Matsumoto, Yukio; Sugimoto, Yuji; Konishi, Tatsuya; Sawae, Yoshiro; Okada, Kaoru; Takaki, Koji; Ninomiya, Kiyoshi; Kumagai, Yukio; Sumita, Ikuo; Terashima, Takanori; Misumi, Hiroyasu; Shimono, Nobuyuki; Takamoto, Masashi; Yoshimura, Toshikazu; Harada, Yasuko; Harada, Susumu; Ishibashi, Tsuneo; Arakawa, Kikuo; Kono, Kenji; Ohizumi, Kotaro; Ichikawa, Yoichiro; Tokunaga, Naoto; Shiraishi, Tsuneaki; Tanaka, Masako; Kawahara, Masao; Saisho, Masazumi; Kawaguchi, Shinzo; Shigematsu, Hironari; Mitsutake, Yoshiyuki; Tanaka, Humio; Hara, Kohei; Kohno, Shigeru; Koga, Hironobu; Kaku, Mitsuo; Tomono, Kazunori; Okuno, Kazuhiro; Fukushima, Kiyoyasu; Inoue, Yuichi; Suyama, Naohumi; Nakatomi, Masao; Ishiguro, Miyako; Sawa, Hideaki; Matsumoto, Keizo; Nagatake, Tsuyoshi; Utsunomiya, Yoshiaki; Tao, Misao; Takasugi, Masakazu; Degawa, Satoshi; Morito, Toshihiro; Sakamoto, Tasuku; Nasu, Masaru; Goto, Yoichiro; Yamasaki, Tohru; Goto, Jun; Kitagawa, Kazuo; Ando, Masayuki; Suga, Moritaka; Yamazaki, Hisato; Tsunoda, Yoichiro; Kai, Sunako; Urata, Atsushi; Fukuda, Yasutsugu; Tokunaga, Katsumasa; Shima, Kiyoshi; Takenaka, Shinobu; Saito, Atsushi; Fukuhara, Hiroshi; Inadome, Jun; Nakamura, Hiroaki; Kaneshima, Hiroshi; Ohwan, Isoko; Kusano, Nobuchika; Ishikawa, Masakiyo; Miyasato, Akiko; Nakashima, Mitsuyoshi; Yamaguchi, Keizo.
In: Japanese Journal of Chemotherapy, Vol. 43, No. 1, 1995, p. 41-62.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - A comparative study of biapenem and imipenem/cilastatin for bacterial pneumonia
AU - Matsumoto, Fumio
AU - Imai, Takeo
AU - Sakurai, Iwao
AU - Saito, Akira
AU - Tomizawa, Masumi
AU - Abe, Shosaku
AU - Honda, Yasuhito
AU - Sekine, Kyuichiro
AU - Igarashi, Tomofumi
AU - Imai, Sumio
AU - Watanabe, Hideaki
AU - Inoue, Yuji
AU - Takebe, Kazuo
AU - Tamura, Toyokazu
AU - Masuda, Mitsuo
AU - Tamura, Masashi
AU - Konishi, Kazuki
AU - Mouri, Tokashi
AU - Tanifuji, Yukio
AU - Takeuchi, Kenichi
AU - Hirano, Haruto
AU - Shirato, Kunio
AU - Tanno, Yasuo
AU - Sakamoto, Masahiro
AU - Nukiwa, Toshihiro
AU - Watanabe, Akira
AU - Konno, Kiyoshi
AU - Sayama, Tsuneo
AU - Shoji, Satoru
AU - Nagai, Kosaku
AU - Niizuma, Kazunao
AU - Nakai, Yusi
AU - Honda, Yoshihiro
AU - Honma, Mitsunobu
AU - Sato, Kazuo
AU - Arakawa, Masaaki
AU - Wada, Koichi
AU - Tsukada, Hiroki
AU - Hoshino, Shigeyuki
AU - Iwata, Humihide
AU - Aoki, Nobuki
AU - Sekine, Osamu
AU - Suzuki, Yasutoshi
AU - Takeda, Hajimu
AU - Katsu, Masataka
AU - Aosaki, Noboru
AU - Nakamura, Morio
AU - Shimada, Kaoru
AU - Sano, Yasuyuki
AU - Akiyama, Norihisa
AU - Arai, Yasuo
AU - Tanaka, Yasuko
AU - Sakai, Osamu
AU - Shiba, Kohya
AU - Yoshida, Masaki
AU - Okada, Kazuhisa
AU - Tanimoto, Hiroichi
AU - Obara, Kazuo
AU - Komatsuzaki, Katsumi
AU - Tanabe, Osamu
AU - Nagamura, Hideo
AU - Shimizu, Ayumu
AU - Mochizuki, Taichi
AU - Mori, Takeshi
AU - Isonuma, Hiroshi
AU - Takahashi, Mayumi
AU - Nakata, Kohichiro
AU - Narui, Kohji
AU - Kudo, Kohichiro
AU - Tanabe, Noriko
AU - Hayashi, Izumi
AU - Kunii, Otohiko
AU - Nishiya, Hazime
AU - Ono, Yasuo
AU - Yamaguchi, Morimichi
AU - Sugiyama, Hazime
AU - Uzuka, Yoshio
AU - Shishido, Harumi
AU - Baba, Motoo
AU - Kobayashi, Hiroyuki
AU - Takeda, Hiroaki
AU - Sakayori, Tohru
AU - Miura, Hiroshi
AU - Oshitani, Hiroshi
AU - Yoshida, Masahiko
AU - Ohkubo, Takao
AU - Ikeda, Hirotada
AU - Tani, Kenji
AU - Kaneko, Tamotsu
AU - Chiba, Jun
AU - Nakamura, Toshio
AU - Hasegawa, Hideyuki
AU - Sakamoto, Hiroshi
AU - Shimada, Jingoro
AU - Hori, Seiji
AU - Odagiri, Shigeki
AU - Suzuki, Kaneo
AU - Sumitomo, Midori
AU - Amano, Taizi
AU - Hirai, Yoshihiro
AU - Hagiwara, Eri
AU - Irimaziri, Shoichiro
AU - Matsuoka, Yasuo
AU - Obana, Mitsuo
AU - Sato, Atsuhiko
AU - Chida, Kingo
AU - Tamura, Ryoji
AU - Suda, Takahumi
AU - Yagi, Takeshi
AU - Toyoshima, Mikio
AU - Shirai, Masahiro
AU - Taniguchi, Masami
AU - Yasuda, Kazuo
AU - Uchiyama, Hiroshi
AU - Nakano, Yutaka
AU - Shimokata, Kaoru
AU - Ichiyama, Satoshi
AU - Sakai, Shuzo
AU - Minami, Hironobu
AU - Yamamoto, Masashi
AU - Yagi, Tetsuya
AU - Nakanishi, Kazuo
AU - Suda, Katsuhisa
AU - Hara, Tohru
AU - Yoshimoto, Tetsusuke
AU - Yamamoto, Toshiyuki
AU - Suzuki, Kanzo
AU - Matsuura, Tohru
AU - Yamakoshi, Masahiro
AU - Takeuchi, Toshihiko
AU - Yamada, Yasuo
AU - Yamamoto, Toshinobu
AU - Nakamura, Atsushi
AU - Hanaki, Hidekazu
AU - Takeyama, Shinji
AU - Kawakami, Makoto
AU - Yamamoto, Kazuhide
AU - Usami, Ikuji
AU - Kuroki, Hideaki
AU - Miki, Fumio
AU - Narita, Nobuhiro
AU - Sawaki, Masayoshi
AU - Mikasa, Keiichi
AU - Konishi, Mitsuru
AU - Soejima, Rinzo
AU - Niki, Yoshihito
AU - Moriya, Osamu
AU - Matsushima, Toshiharu
AU - Kimura, Makoto
AU - Yamakido, Michiro
AU - Hasegawa, Kenji
AU - Yamaoka, Naoki
AU - Miyazawa, Teruomi
AU - Doi, Masao
AU - Arita, Kenichi
AU - Daido, Kazuhiro
AU - Ejima, Takeshi
AU - Kurimura, Osamu
AU - Hiramoto, Masahiko
AU - Tominaga, Naoko
AU - Saigo, Kazumasa
AU - Sasaki, Takao
AU - Matsumoto, Yukio
AU - Sugimoto, Yuji
AU - Konishi, Tatsuya
AU - Sawae, Yoshiro
AU - Okada, Kaoru
AU - Takaki, Koji
AU - Ninomiya, Kiyoshi
AU - Kumagai, Yukio
AU - Sumita, Ikuo
AU - Terashima, Takanori
AU - Misumi, Hiroyasu
AU - Shimono, Nobuyuki
AU - Takamoto, Masashi
AU - Yoshimura, Toshikazu
AU - Harada, Yasuko
AU - Harada, Susumu
AU - Ishibashi, Tsuneo
AU - Arakawa, Kikuo
AU - Kono, Kenji
AU - Ohizumi, Kotaro
AU - Ichikawa, Yoichiro
AU - Tokunaga, Naoto
AU - Shiraishi, Tsuneaki
AU - Tanaka, Masako
AU - Kawahara, Masao
AU - Saisho, Masazumi
AU - Kawaguchi, Shinzo
AU - Shigematsu, Hironari
AU - Mitsutake, Yoshiyuki
AU - Tanaka, Humio
AU - Hara, Kohei
AU - Kohno, Shigeru
AU - Koga, Hironobu
AU - Kaku, Mitsuo
AU - Tomono, Kazunori
AU - Okuno, Kazuhiro
AU - Fukushima, Kiyoyasu
AU - Inoue, Yuichi
AU - Suyama, Naohumi
AU - Nakatomi, Masao
AU - Ishiguro, Miyako
AU - Sawa, Hideaki
AU - Matsumoto, Keizo
AU - Nagatake, Tsuyoshi
AU - Utsunomiya, Yoshiaki
AU - Tao, Misao
AU - Takasugi, Masakazu
AU - Degawa, Satoshi
AU - Morito, Toshihiro
AU - Sakamoto, Tasuku
AU - Nasu, Masaru
AU - Goto, Yoichiro
AU - Yamasaki, Tohru
AU - Goto, Jun
AU - Kitagawa, Kazuo
AU - Ando, Masayuki
AU - Suga, Moritaka
AU - Yamazaki, Hisato
AU - Tsunoda, Yoichiro
AU - Kai, Sunako
AU - Urata, Atsushi
AU - Fukuda, Yasutsugu
AU - Tokunaga, Katsumasa
AU - Shima, Kiyoshi
AU - Takenaka, Shinobu
AU - Saito, Atsushi
AU - Fukuhara, Hiroshi
AU - Inadome, Jun
AU - Nakamura, Hiroaki
AU - Kaneshima, Hiroshi
AU - Ohwan, Isoko
AU - Kusano, Nobuchika
AU - Ishikawa, Masakiyo
AU - Miyasato, Akiko
AU - Nakashima, Mitsuyoshi
AU - Yamaguchi, Keizo
N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - The clinical efficacy, safety and usefulness of biapenem (BIPM), a new carbapenem antibiotic for injection, were evaluated in bacterial pneumonia in a comparative study with imipenem/cilastatin (IPM/CS). Patients were given 600 mg (potency) of BIPM or 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) for 14 days, and the following results were obtained: 1. A total of 183 cases were enrolled in this study, and 146 cases were evaluated for clinical efficacy. Efficacy rates were 94.8% (73/77) in the BIPM group and 92.8% (64/69) in the IPM/CS group, with no significant difference between the two groups. 2. Bacteriological eradication rates were 90.9% (20/22) in the BIPM group and 93.1% (27/29) in the IPM/CS group, with no significant difference between the two groups. 3. The incidence of adverse reaction was 3.4% (2/89) in the BIPM group and 3.6% (3/83) in the IPM/CS group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 29.5% (26/88) in the BIPM group and 25.6% (20/78) in the IPM/CS group. There was no significant difference between the two groups. 4. The usefulness rates were 94.8% (73/77) in the BIPM group and 88.6% (62/70) in the IPM/CS group. There was no significant difference between the two groups. No significant differences were observed between 600 mg (potency) of BIPM and 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) with respect to any of the above parameters. These results indicate that BIPM is useful for the treatment of bacterial pneumonia and lung abscess.
AB - The clinical efficacy, safety and usefulness of biapenem (BIPM), a new carbapenem antibiotic for injection, were evaluated in bacterial pneumonia in a comparative study with imipenem/cilastatin (IPM/CS). Patients were given 600 mg (potency) of BIPM or 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) for 14 days, and the following results were obtained: 1. A total of 183 cases were enrolled in this study, and 146 cases were evaluated for clinical efficacy. Efficacy rates were 94.8% (73/77) in the BIPM group and 92.8% (64/69) in the IPM/CS group, with no significant difference between the two groups. 2. Bacteriological eradication rates were 90.9% (20/22) in the BIPM group and 93.1% (27/29) in the IPM/CS group, with no significant difference between the two groups. 3. The incidence of adverse reaction was 3.4% (2/89) in the BIPM group and 3.6% (3/83) in the IPM/CS group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 29.5% (26/88) in the BIPM group and 25.6% (20/78) in the IPM/CS group. There was no significant difference between the two groups. 4. The usefulness rates were 94.8% (73/77) in the BIPM group and 88.6% (62/70) in the IPM/CS group. There was no significant difference between the two groups. No significant differences were observed between 600 mg (potency) of BIPM and 1,000 mg (potency)/1,000 mg of IPM/CS daily (b.i.d.) with respect to any of the above parameters. These results indicate that BIPM is useful for the treatment of bacterial pneumonia and lung abscess.
UR - http://www.scopus.com/inward/record.url?scp=0028948255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028948255&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1995.43.41
DO - 10.11250/chemotherapy1995.43.41
M3 - Article
AN - SCOPUS:0028948255
VL - 43
SP - 41
EP - 62
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
SN - 1340-7007
IS - 1
ER -