A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B

Kazuyuki Matsumoto, Yasuhiro Miyake, Hirokazu Miyatake, Masahiro Takahara, Takayuki Imada, Satoru Yagi, Tatsuya Toyokawa, Morihito Nakatsu, Masaharu Ando, Mamoru Hirohata

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy, 20%-30% have a fatal outcome. In this report, we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and corticosteroid. In both cases, rapid reductions in serum hepatitis B virus (HBV)-DNA levels were observed, and corticosteroid was stopped after serum HBV-DNA levels became undetectable. Entecavir treatment was continued. Generally, entecavir treatment reduced serum HBV-DNA levels rapidly, although the improvement in liver function was delayed by a few weeks. During this time lag, liver cell injury continued and the disease progressed. Corticosteroid suppressed the excessive host immune response and was useful for stopping progressive deterioration. A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B.

Original languageEnglish
Pages (from-to)1650-1652
Number of pages3
JournalWorld journal of gastroenterology
Volume15
Issue number13
DOIs
Publication statusPublished - Apr 7 2009

Keywords

  • Acute exacerbation
  • Chronic hepatitis B
  • Corticosteroid
  • Entecavir
  • Hepatic coma
  • Hepatitis B virus

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B'. Together they form a unique fingerprint.

Cite this