A combination of roxithromycin and imipenem as an antimicrobial strategy against biofilms formed by Staphylococcus aureus

O. Yamasaki, H. Akiyama, Y. Toi, J. Arata

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We examined the effects of a combination of roxithromycin and imipenem on a biofilm model of Staphylococcus aureus. Treatment with roxithromycin alone and imipenem alone did not decrease the number of viable bacterial cells compared with the control. However, a combination treatment of roxithromycin and imipenem significantly decreased the number of viable bacterial cells on day 8 after inoculation in the in vivo model (P < 0.01). On days 5 and 8 after inoculation, numerous polymorphonuclear leucocytes and macrophages invaded the bacterial clusters in the roxithromycin- and roxithromycin/imipenem-treated groups, but did not invade the control or imipenem-treated groups. The present study indicated that a combination of roxithromycin and imipenem is a potentially effective treatment for S. aureus biofilm-associated skin infections as it can induce the invasion of polymorphonuclear leucocytes into the biofilm.

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume48
Issue number4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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