A clinical study on 64 cases of laryngeal granuloma

Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Michihiro Nakada, Hidenori Marunaka, Kazunori Nishizaki

Research output: Contribution to journalArticle


Vocal process granulomas are mainly associated with vocal abuse, gastroesophageal reflux disease (GERD), or endotracheal intubation. In the present study, we evaluate the prognostic factors and the usefulness of a grading system in 64 patients with vocal process granulomas. We classified the granuloma which limited the vocal process of the arytenoids cartilage as grade I, and which originated from the vocal process but extended beyond the vocal process of the arytenoid cartilage as grade II, according to the grading system proposed by Wang CP, et al. First, we treated this disease with conservative treatments including a proton pump inhibitor, steroid inhalation, or voice therapy. Surgical treatment was reserved for failures of conservative treatments or when the diagnosis was in doubt. The overall post-surgical recurrence rate was 65.7%, and it was significantly higher in male than female patients, and in younger than older patients. The overall remission rate was 79.7%. A multivariate analysis revealed that Grade II was a significantly poor prognostic factor and the patients with BMI ≥ 23 or Age

Original languageEnglish
Pages (from-to)860-866
Number of pages7
JournalJournal of Otolaryngology of Japan
Issue number6
Publication statusPublished - 2016


  • Grading
  • Recurrence
  • Vocal process granuloma

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Tachibana, T., Orita, Y., Makino, T., Ogawara, Y., Matsuyama, Y., Shimizu, A., Nakada, M., Marunaka, H., & Nishizaki, K. (2016). A clinical study on 64 cases of laryngeal granuloma. Journal of Otolaryngology of Japan, 119(6), 860-866.