A clinical study of renal pelvic and ureteral cancer: Prognosis and frequency of subsequent bladder cancer following surgical treatment

Masami Watanabe, Toshihide Hayashi, Masatake Takamatsu, Akihiro Kamitani, Miyabi Inoue, Koichi Morisue, Shin Irie, Tetsuzo Kaneshige

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: A retrospective investigation of patients presenting with renal pelvic and ureteral cancer was performed. This study focused on the prognostic factors and frequency of subsequent bladder cancer following surgical treatment. Materials and Methods: Forty-five patients presenting with transitional cell carcinoma, who had undergone nephroureterectomy at the Department of Urology, Okayama Central Hospital, from March 1990 to November 2000, were reviewed. Various factors were evaluated according to survival and non-bladder cancer occurrence rates. The Kaplan-Meier method was used in the analyses. Results: Patients consisted of 33 males and 12 females (mean age was 71.7). Seventeen patients exhibited renal pelvic cancer, 25 cases displayed ureteral cancer and three subjects presented with multiple cancers. Eleven patients had received treatment for precedent or coexistent superficial bladder cancer by transurethral resection. The overall 5-year survival rate was 71.9%. Ten patients died as a result of the disease; in all cases, lymph node or distant metastasis had progressed. Pathological T factor, tumor grade and pN factor demonstrated a significant effect on survival; however, sex, age, tumor localization and incidence of subsequent bladder cancer had no influence on survival. The 5-year non-bladder cancer occurrence rate was 38.8%; additionally, all subsequent bladder cancer was disclosed within three years. Tumor multiplicity exclusively in the upper urinary tract significantly affected occurrence of bladder cancer. T factor and tumor grade revealed no correlation to occurrence. Conclusions: Adjuvant chemotherapy for prevention of clinical metastasis should be considered in cases involving pT3 or higher stage, grade 3, or in instances of pathologically confirmed lymph node metastasis. The significant occurrence of subsequent bladder cancer in the case of tumor multiplicity suggested that prophylactic therapy such as intravesical BCG instillation or chemotherapy might be beneficial.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalJapanese Journal of Urology
Volume94
Issue number3
Publication statusPublished - Mar 2003

Fingerprint

Ureteral Neoplasms
Pelvic Neoplasms
Kidney Neoplasms
Urinary Bladder Neoplasms
Neoplasms
Therapeutics
Neoplasm Metastasis
Survival
Lymph Nodes
Intravesical Administration
Clinical Studies
Transitional Cell Carcinoma
Urology
Adjuvant Chemotherapy
Mycobacterium bovis
Urinary Tract
Survival Rate
Drug Therapy

Keywords

  • Prognosis
  • Renal pelvic and ureteral cancer
  • Subsequent bladder cancer

ASJC Scopus subject areas

  • Urology

Cite this

A clinical study of renal pelvic and ureteral cancer : Prognosis and frequency of subsequent bladder cancer following surgical treatment. / Watanabe, Masami; Hayashi, Toshihide; Takamatsu, Masatake; Kamitani, Akihiro; Inoue, Miyabi; Morisue, Koichi; Irie, Shin; Kaneshige, Tetsuzo.

In: Japanese Journal of Urology, Vol. 94, No. 3, 03.2003, p. 428-433.

Research output: Contribution to journalArticle

Watanabe, M, Hayashi, T, Takamatsu, M, Kamitani, A, Inoue, M, Morisue, K, Irie, S & Kaneshige, T 2003, 'A clinical study of renal pelvic and ureteral cancer: Prognosis and frequency of subsequent bladder cancer following surgical treatment', Japanese Journal of Urology, vol. 94, no. 3, pp. 428-433.
Watanabe, Masami ; Hayashi, Toshihide ; Takamatsu, Masatake ; Kamitani, Akihiro ; Inoue, Miyabi ; Morisue, Koichi ; Irie, Shin ; Kaneshige, Tetsuzo. / A clinical study of renal pelvic and ureteral cancer : Prognosis and frequency of subsequent bladder cancer following surgical treatment. In: Japanese Journal of Urology. 2003 ; Vol. 94, No. 3. pp. 428-433.
@article{ea6f7d239f1b4cdd811e3b4db9f5b6de,
title = "A clinical study of renal pelvic and ureteral cancer: Prognosis and frequency of subsequent bladder cancer following surgical treatment",
abstract = "Purpose: A retrospective investigation of patients presenting with renal pelvic and ureteral cancer was performed. This study focused on the prognostic factors and frequency of subsequent bladder cancer following surgical treatment. Materials and Methods: Forty-five patients presenting with transitional cell carcinoma, who had undergone nephroureterectomy at the Department of Urology, Okayama Central Hospital, from March 1990 to November 2000, were reviewed. Various factors were evaluated according to survival and non-bladder cancer occurrence rates. The Kaplan-Meier method was used in the analyses. Results: Patients consisted of 33 males and 12 females (mean age was 71.7). Seventeen patients exhibited renal pelvic cancer, 25 cases displayed ureteral cancer and three subjects presented with multiple cancers. Eleven patients had received treatment for precedent or coexistent superficial bladder cancer by transurethral resection. The overall 5-year survival rate was 71.9{\%}. Ten patients died as a result of the disease; in all cases, lymph node or distant metastasis had progressed. Pathological T factor, tumor grade and pN factor demonstrated a significant effect on survival; however, sex, age, tumor localization and incidence of subsequent bladder cancer had no influence on survival. The 5-year non-bladder cancer occurrence rate was 38.8{\%}; additionally, all subsequent bladder cancer was disclosed within three years. Tumor multiplicity exclusively in the upper urinary tract significantly affected occurrence of bladder cancer. T factor and tumor grade revealed no correlation to occurrence. Conclusions: Adjuvant chemotherapy for prevention of clinical metastasis should be considered in cases involving pT3 or higher stage, grade 3, or in instances of pathologically confirmed lymph node metastasis. The significant occurrence of subsequent bladder cancer in the case of tumor multiplicity suggested that prophylactic therapy such as intravesical BCG instillation or chemotherapy might be beneficial.",
keywords = "Prognosis, Renal pelvic and ureteral cancer, Subsequent bladder cancer",
author = "Masami Watanabe and Toshihide Hayashi and Masatake Takamatsu and Akihiro Kamitani and Miyabi Inoue and Koichi Morisue and Shin Irie and Tetsuzo Kaneshige",
year = "2003",
month = "3",
language = "English",
volume = "94",
pages = "428--433",
journal = "Japanese Journal of Urology",
issn = "0021-5287",
publisher = "THE JAPANESE UROLOGICAL ASSOCIATION",
number = "3",

}

TY - JOUR

T1 - A clinical study of renal pelvic and ureteral cancer

T2 - Prognosis and frequency of subsequent bladder cancer following surgical treatment

AU - Watanabe, Masami

AU - Hayashi, Toshihide

AU - Takamatsu, Masatake

AU - Kamitani, Akihiro

AU - Inoue, Miyabi

AU - Morisue, Koichi

AU - Irie, Shin

AU - Kaneshige, Tetsuzo

PY - 2003/3

Y1 - 2003/3

N2 - Purpose: A retrospective investigation of patients presenting with renal pelvic and ureteral cancer was performed. This study focused on the prognostic factors and frequency of subsequent bladder cancer following surgical treatment. Materials and Methods: Forty-five patients presenting with transitional cell carcinoma, who had undergone nephroureterectomy at the Department of Urology, Okayama Central Hospital, from March 1990 to November 2000, were reviewed. Various factors were evaluated according to survival and non-bladder cancer occurrence rates. The Kaplan-Meier method was used in the analyses. Results: Patients consisted of 33 males and 12 females (mean age was 71.7). Seventeen patients exhibited renal pelvic cancer, 25 cases displayed ureteral cancer and three subjects presented with multiple cancers. Eleven patients had received treatment for precedent or coexistent superficial bladder cancer by transurethral resection. The overall 5-year survival rate was 71.9%. Ten patients died as a result of the disease; in all cases, lymph node or distant metastasis had progressed. Pathological T factor, tumor grade and pN factor demonstrated a significant effect on survival; however, sex, age, tumor localization and incidence of subsequent bladder cancer had no influence on survival. The 5-year non-bladder cancer occurrence rate was 38.8%; additionally, all subsequent bladder cancer was disclosed within three years. Tumor multiplicity exclusively in the upper urinary tract significantly affected occurrence of bladder cancer. T factor and tumor grade revealed no correlation to occurrence. Conclusions: Adjuvant chemotherapy for prevention of clinical metastasis should be considered in cases involving pT3 or higher stage, grade 3, or in instances of pathologically confirmed lymph node metastasis. The significant occurrence of subsequent bladder cancer in the case of tumor multiplicity suggested that prophylactic therapy such as intravesical BCG instillation or chemotherapy might be beneficial.

AB - Purpose: A retrospective investigation of patients presenting with renal pelvic and ureteral cancer was performed. This study focused on the prognostic factors and frequency of subsequent bladder cancer following surgical treatment. Materials and Methods: Forty-five patients presenting with transitional cell carcinoma, who had undergone nephroureterectomy at the Department of Urology, Okayama Central Hospital, from March 1990 to November 2000, were reviewed. Various factors were evaluated according to survival and non-bladder cancer occurrence rates. The Kaplan-Meier method was used in the analyses. Results: Patients consisted of 33 males and 12 females (mean age was 71.7). Seventeen patients exhibited renal pelvic cancer, 25 cases displayed ureteral cancer and three subjects presented with multiple cancers. Eleven patients had received treatment for precedent or coexistent superficial bladder cancer by transurethral resection. The overall 5-year survival rate was 71.9%. Ten patients died as a result of the disease; in all cases, lymph node or distant metastasis had progressed. Pathological T factor, tumor grade and pN factor demonstrated a significant effect on survival; however, sex, age, tumor localization and incidence of subsequent bladder cancer had no influence on survival. The 5-year non-bladder cancer occurrence rate was 38.8%; additionally, all subsequent bladder cancer was disclosed within three years. Tumor multiplicity exclusively in the upper urinary tract significantly affected occurrence of bladder cancer. T factor and tumor grade revealed no correlation to occurrence. Conclusions: Adjuvant chemotherapy for prevention of clinical metastasis should be considered in cases involving pT3 or higher stage, grade 3, or in instances of pathologically confirmed lymph node metastasis. The significant occurrence of subsequent bladder cancer in the case of tumor multiplicity suggested that prophylactic therapy such as intravesical BCG instillation or chemotherapy might be beneficial.

KW - Prognosis

KW - Renal pelvic and ureteral cancer

KW - Subsequent bladder cancer

UR - http://www.scopus.com/inward/record.url?scp=0037359338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037359338&partnerID=8YFLogxK

M3 - Article

C2 - 12710077

AN - SCOPUS:0037359338

VL - 94

SP - 428

EP - 433

JO - Japanese Journal of Urology

JF - Japanese Journal of Urology

SN - 0021-5287

IS - 3

ER -