A clinical study of changes in therapy for gastroesophageal varices and its clinical evaluation

Hitoshi Takeuchi, Takuya Fukazawa, Takeshi Kawashima, Keisho Murakami, Masahiko Nishizaki, Takashi Yoshioka, Yasuhiro Yunoki, Kouji Tanakaya, Masayoshi Yasui, Eiji Konaga, Yuichiro Mikami, Yasuhiro Makino, Toshifumi Yoshioka, Hiroko Yamasaki

Research output: Contribution to journalArticle

Abstract

Two hundred and twelve patients with cardioesophageal varices were treated in Iwakuni National Hospital from January 1972 to December 1991. These patients were analyzed according to the treatment (operation, endoscopic injection sclerotherapy; EIS, EIS and operation). EIS cases have increased in the 1980s. Nowadays, about 90% of patients were treated with this method. Surgical treatment was chosen to the patients of cardial varices or secondary hypersplenism due to idiopathic portal hypertension. Prognosis was best in the patients with EIS and operation (p<0.05). There was no significant difference in prognosis between the patients with operation and those with EIS. However, prognosis of EIS was better in Child C or emergent patients. In patients with operation, liver failure was a main cause of death. On the other hand, in patients with EIS, rebleeding from varices was a main cause of death especially in the late period. From these observations, combination of operation and EIS is the most useful therapy to get a long survival time. However, transection of esophagus is difficult because of its fibrous change after EIS. We devised a new method to solve this problem. In our method, transection was carried out in the lower portion two to three centimeters below the esophagogastric junction with EEA-31® (US Auto Suture, Norwalk, Connecticut, USA) instead of the lower esophagus with EEA-25® or EEA-28®. Nonsurgical intervention for cardial varices and hypersplenism is remained to be established.

Original languageEnglish
Pages (from-to)644-649
Number of pages6
JournalJapanese Journal of National Medical Services
Volume49
Issue number8
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Varicose Veins
Hypersplenism
Therapeutics
Esophagus
Cause of Death
Clinical Studies
Esophagogastric Junction
Sclerotherapy
Liver Failure
Sutures
Injections
Survival

Keywords

  • cardial transection
  • cardioesophageal varices
  • endoscopic injection sclerotherapy
  • esophageal transection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A clinical study of changes in therapy for gastroesophageal varices and its clinical evaluation. / Takeuchi, Hitoshi; Fukazawa, Takuya; Kawashima, Takeshi; Murakami, Keisho; Nishizaki, Masahiko; Yoshioka, Takashi; Yunoki, Yasuhiro; Tanakaya, Kouji; Yasui, Masayoshi; Konaga, Eiji; Mikami, Yuichiro; Makino, Yasuhiro; Yoshioka, Toshifumi; Yamasaki, Hiroko.

In: Japanese Journal of National Medical Services, Vol. 49, No. 8, 1995, p. 644-649.

Research output: Contribution to journalArticle

Takeuchi, H, Fukazawa, T, Kawashima, T, Murakami, K, Nishizaki, M, Yoshioka, T, Yunoki, Y, Tanakaya, K, Yasui, M, Konaga, E, Mikami, Y, Makino, Y, Yoshioka, T & Yamasaki, H 1995, 'A clinical study of changes in therapy for gastroesophageal varices and its clinical evaluation', Japanese Journal of National Medical Services, vol. 49, no. 8, pp. 644-649. https://doi.org/10.11261/iryo1946.49.644
Takeuchi, Hitoshi ; Fukazawa, Takuya ; Kawashima, Takeshi ; Murakami, Keisho ; Nishizaki, Masahiko ; Yoshioka, Takashi ; Yunoki, Yasuhiro ; Tanakaya, Kouji ; Yasui, Masayoshi ; Konaga, Eiji ; Mikami, Yuichiro ; Makino, Yasuhiro ; Yoshioka, Toshifumi ; Yamasaki, Hiroko. / A clinical study of changes in therapy for gastroesophageal varices and its clinical evaluation. In: Japanese Journal of National Medical Services. 1995 ; Vol. 49, No. 8. pp. 644-649.
@article{ae00bcd24b064e738ed2a8d8b3935d75,
title = "A clinical study of changes in therapy for gastroesophageal varices and its clinical evaluation",
abstract = "Two hundred and twelve patients with cardioesophageal varices were treated in Iwakuni National Hospital from January 1972 to December 1991. These patients were analyzed according to the treatment (operation, endoscopic injection sclerotherapy; EIS, EIS and operation). EIS cases have increased in the 1980s. Nowadays, about 90{\%} of patients were treated with this method. Surgical treatment was chosen to the patients of cardial varices or secondary hypersplenism due to idiopathic portal hypertension. Prognosis was best in the patients with EIS and operation (p<0.05). There was no significant difference in prognosis between the patients with operation and those with EIS. However, prognosis of EIS was better in Child C or emergent patients. In patients with operation, liver failure was a main cause of death. On the other hand, in patients with EIS, rebleeding from varices was a main cause of death especially in the late period. From these observations, combination of operation and EIS is the most useful therapy to get a long survival time. However, transection of esophagus is difficult because of its fibrous change after EIS. We devised a new method to solve this problem. In our method, transection was carried out in the lower portion two to three centimeters below the esophagogastric junction with EEA-31{\circledR} (US Auto Suture, Norwalk, Connecticut, USA) instead of the lower esophagus with EEA-25{\circledR} or EEA-28{\circledR}. Nonsurgical intervention for cardial varices and hypersplenism is remained to be established.",
keywords = "cardial transection, cardioesophageal varices, endoscopic injection sclerotherapy, esophageal transection",
author = "Hitoshi Takeuchi and Takuya Fukazawa and Takeshi Kawashima and Keisho Murakami and Masahiko Nishizaki and Takashi Yoshioka and Yasuhiro Yunoki and Kouji Tanakaya and Masayoshi Yasui and Eiji Konaga and Yuichiro Mikami and Yasuhiro Makino and Toshifumi Yoshioka and Hiroko Yamasaki",
year = "1995",
doi = "10.11261/iryo1946.49.644",
language = "English",
volume = "49",
pages = "644--649",
journal = "IRYO - Japanese Journal of National Medical Services",
issn = "0021-1699",
publisher = "Japanese Society of National Medical Services",
number = "8",

}

TY - JOUR

T1 - A clinical study of changes in therapy for gastroesophageal varices and its clinical evaluation

AU - Takeuchi, Hitoshi

AU - Fukazawa, Takuya

AU - Kawashima, Takeshi

AU - Murakami, Keisho

AU - Nishizaki, Masahiko

AU - Yoshioka, Takashi

AU - Yunoki, Yasuhiro

AU - Tanakaya, Kouji

AU - Yasui, Masayoshi

AU - Konaga, Eiji

AU - Mikami, Yuichiro

AU - Makino, Yasuhiro

AU - Yoshioka, Toshifumi

AU - Yamasaki, Hiroko

PY - 1995

Y1 - 1995

N2 - Two hundred and twelve patients with cardioesophageal varices were treated in Iwakuni National Hospital from January 1972 to December 1991. These patients were analyzed according to the treatment (operation, endoscopic injection sclerotherapy; EIS, EIS and operation). EIS cases have increased in the 1980s. Nowadays, about 90% of patients were treated with this method. Surgical treatment was chosen to the patients of cardial varices or secondary hypersplenism due to idiopathic portal hypertension. Prognosis was best in the patients with EIS and operation (p<0.05). There was no significant difference in prognosis between the patients with operation and those with EIS. However, prognosis of EIS was better in Child C or emergent patients. In patients with operation, liver failure was a main cause of death. On the other hand, in patients with EIS, rebleeding from varices was a main cause of death especially in the late period. From these observations, combination of operation and EIS is the most useful therapy to get a long survival time. However, transection of esophagus is difficult because of its fibrous change after EIS. We devised a new method to solve this problem. In our method, transection was carried out in the lower portion two to three centimeters below the esophagogastric junction with EEA-31® (US Auto Suture, Norwalk, Connecticut, USA) instead of the lower esophagus with EEA-25® or EEA-28®. Nonsurgical intervention for cardial varices and hypersplenism is remained to be established.

AB - Two hundred and twelve patients with cardioesophageal varices were treated in Iwakuni National Hospital from January 1972 to December 1991. These patients were analyzed according to the treatment (operation, endoscopic injection sclerotherapy; EIS, EIS and operation). EIS cases have increased in the 1980s. Nowadays, about 90% of patients were treated with this method. Surgical treatment was chosen to the patients of cardial varices or secondary hypersplenism due to idiopathic portal hypertension. Prognosis was best in the patients with EIS and operation (p<0.05). There was no significant difference in prognosis between the patients with operation and those with EIS. However, prognosis of EIS was better in Child C or emergent patients. In patients with operation, liver failure was a main cause of death. On the other hand, in patients with EIS, rebleeding from varices was a main cause of death especially in the late period. From these observations, combination of operation and EIS is the most useful therapy to get a long survival time. However, transection of esophagus is difficult because of its fibrous change after EIS. We devised a new method to solve this problem. In our method, transection was carried out in the lower portion two to three centimeters below the esophagogastric junction with EEA-31® (US Auto Suture, Norwalk, Connecticut, USA) instead of the lower esophagus with EEA-25® or EEA-28®. Nonsurgical intervention for cardial varices and hypersplenism is remained to be established.

KW - cardial transection

KW - cardioesophageal varices

KW - endoscopic injection sclerotherapy

KW - esophageal transection

UR - http://www.scopus.com/inward/record.url?scp=85007733466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007733466&partnerID=8YFLogxK

U2 - 10.11261/iryo1946.49.644

DO - 10.11261/iryo1946.49.644

M3 - Article

VL - 49

SP - 644

EP - 649

JO - IRYO - Japanese Journal of National Medical Services

JF - IRYO - Japanese Journal of National Medical Services

SN - 0021-1699

IS - 8

ER -