A clinical retrospective study of surgical treatment for medication-related osteonecrosis of the jaw

Shintaro Sukegawa, Takahiro Kanno, Hotaka Kawai, Satoko Nakamura, Akane Shibata, Yuka Sukegawa-Takahashi, Hitoshi Nagatsuka, Yoshihiko Furuki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In 2014, the American Association of Oral and Maxillofacial Surgery recommended surgical treatment for medication-related osteonecrosis of the jaw (MRONJ) patients classified as stage 3 or those with mobile segments of bony sequestrum. However, there is limited information regarding the healing mechanism in MRONJ surgical treatments. This study aimed to retrospectively elucidate clinical outcomes of the surgical treatment of MRONJ patients. This study included 26 patients (7 men, 19 women; age: 42–92 years; mean ± standard deviation, 75.3 ± 11.7 years) who were classified as stage 3 or had mobile segments of bony sequestrum, and intake of the offending drug was ceased. The sequestrum was removed with surrounding vital bone, and segmental resection was performed in one patient with a pathological mandibular fracture. The outcome was classified into one of the following three categories: “Healing,” “Improvement,” “Unchanged.” and “Exacerbation.” The mean postoperative follow-up period was 16.6 months (3.0 –57.9 months), and complete healing was observed in 21 patients (80.8%), improvement of the lesion was observed in four patients (15.4%), and the outcome of one patient was unchanged (3.8%). The procedure described here may be recommended with relatively high clinical success rate for the patients with MRONJ requiring surgical treatment.

Original languageEnglish
Pages (from-to)447-454
Number of pages8
JournalJournal of Hard Tissue Biology
Volume25
Issue number4
DOIs
Publication statusPublished - 2016

Fingerprint

Osteonecrosis
Jaw
Surgery
Bone
Retrospective Studies
Pharmaceutical Preparations
Oral Surgery
Therapeutics
Mandibular Fractures
Spontaneous Fractures
Clinical Studies
Bone and Bones

Keywords

  • Drug holiday
  • Medication-related osteonecrosis of the jaw
  • Sequestrum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology

Cite this

Sukegawa, S., Kanno, T., Kawai, H., Nakamura, S., Shibata, A., Sukegawa-Takahashi, Y., ... Furuki, Y. (2016). A clinical retrospective study of surgical treatment for medication-related osteonecrosis of the jaw. Journal of Hard Tissue Biology, 25(4), 447-454. https://doi.org/10.2485/jhtb.25.447

A clinical retrospective study of surgical treatment for medication-related osteonecrosis of the jaw. / Sukegawa, Shintaro; Kanno, Takahiro; Kawai, Hotaka; Nakamura, Satoko; Shibata, Akane; Sukegawa-Takahashi, Yuka; Nagatsuka, Hitoshi; Furuki, Yoshihiko.

In: Journal of Hard Tissue Biology, Vol. 25, No. 4, 2016, p. 447-454.

Research output: Contribution to journalArticle

Sukegawa, Shintaro ; Kanno, Takahiro ; Kawai, Hotaka ; Nakamura, Satoko ; Shibata, Akane ; Sukegawa-Takahashi, Yuka ; Nagatsuka, Hitoshi ; Furuki, Yoshihiko. / A clinical retrospective study of surgical treatment for medication-related osteonecrosis of the jaw. In: Journal of Hard Tissue Biology. 2016 ; Vol. 25, No. 4. pp. 447-454.
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