TY - JOUR
T1 - A clinical evaluation of renal amyloidosis in the Japan renal biopsy registry
T2 - a cross-sectional study
AU - Nishi, Shinichi
AU - Muso, Eri
AU - Shimizu, Akira
AU - Sugiyama, Hitoshi
AU - Yokoyama, Hitoshi
AU - Ando, Yukio
AU - Goto, Shunsuke
AU - Fujii, Hideki
N1 - Funding Information:
The authors are grateful for the help and support from the J-RBR committee and all of the colleagues who participated in the J-RBR governed by Japanese Society of Nephrology. This study was supported by a grant-in-aid from the Research Group on Progressive Renal Disease, Grant-in-Aid for Research on Advanced Chronic Kidney Disease, from the Japan Agency for Medical Research and Development, and the Amyloidosis Research Group from the Ministry of Health Labor and Welfare (Number H26-057), Japan.
Publisher Copyright:
© 2016, Japanese Society of Nephrology.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background and aim: The available clinical data are limited in a rare glomerular disease, renal amyloidosis. We aimed to clarify the clinical features of renal amyloidosis from database of the Japan Renal Biopsy Registry (J-RBR). Methods: We performed a cross-sectional study with database of the J-RBR of the Japanese Society of Nephrology. We identified 281 cases of renal amyloidosis from 20,997 cases enrolled into the J-RBR from 2007 to 2014. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared among the levels of ages, amount of urine protein excretion (AUPE) or CKD G stages. Results: The prevalence of renal amyloidosis was 1.3 % (281/20,997). DBP significantly decreased in higher age quartiles (P = 0.034). SBP and DBP did not increase in the progression of AUPE levels and CKD G stages. In multiple regression analysis, eGFR was a significant independent factor for SBP in all cases and a subgroup without hypertensive agents. There was a reverse significant relationship between SBP and eGFR. Conclusion: Blood pressure did not significantly increase in elderly and much proteinuric condition in renal amyloidosis. The progression of CKD and decrease of eGFR did not produce the higher SBP. The mechanism underlying these results remains unclear; however, they are unique features of renal amyloidosis. The couple of hypotensive and hypertensive conditions might produce no relationship between blood pressure and CKD stages.
AB - Background and aim: The available clinical data are limited in a rare glomerular disease, renal amyloidosis. We aimed to clarify the clinical features of renal amyloidosis from database of the Japan Renal Biopsy Registry (J-RBR). Methods: We performed a cross-sectional study with database of the J-RBR of the Japanese Society of Nephrology. We identified 281 cases of renal amyloidosis from 20,997 cases enrolled into the J-RBR from 2007 to 2014. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared among the levels of ages, amount of urine protein excretion (AUPE) or CKD G stages. Results: The prevalence of renal amyloidosis was 1.3 % (281/20,997). DBP significantly decreased in higher age quartiles (P = 0.034). SBP and DBP did not increase in the progression of AUPE levels and CKD G stages. In multiple regression analysis, eGFR was a significant independent factor for SBP in all cases and a subgroup without hypertensive agents. There was a reverse significant relationship between SBP and eGFR. Conclusion: Blood pressure did not significantly increase in elderly and much proteinuric condition in renal amyloidosis. The progression of CKD and decrease of eGFR did not produce the higher SBP. The mechanism underlying these results remains unclear; however, they are unique features of renal amyloidosis. The couple of hypotensive and hypertensive conditions might produce no relationship between blood pressure and CKD stages.
KW - Amyloidosis
KW - Blood pressure
KW - Chronic kidney disease
KW - Nephrotic syndrome
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U2 - 10.1007/s10157-016-1326-0
DO - 10.1007/s10157-016-1326-0
M3 - Article
C2 - 27562765
AN - SCOPUS:84983470390
SN - 1342-1751
VL - 21
SP - 624
EP - 632
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 4
ER -