A Clinical Analysis of Malignant Schwannoma

Toshiyuki Kunisada, Akira Kawai, Toshifumi Ozaki, Shinsuke Sugihara, Kohji Taguchi, Hajime Inoue

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, we reviewed the clinical features of 11 patients with malignant schwannoma who were treated in our institute. Five patients had coexistent von Recklinghausen's disease and one of them showed multifocal occurrence. Patients with the centrally located tumors had a poorer prognosis than those with the others. The overall 3-year survival rate was 36%; 40% in patients with von Recklinghausen's disease and 33% in the others. At the time of the last follow-up, 9 patients had died of the tumor, one continued to be tumor free, and one was alive with tumor. Postoperative local recurrence developed in 5 patients (45%); 4 out of 6 patients (67%) who underwent a marginal excision and one out of 3 (33%) who underwent primary amputation. There was no local recurrence in patients after a wide excision with at least 3cm of normal tissue removed surrounding the tumor in all directions. Nine patients (82%) developed pulmonary metastasis. The effect of adjuvant chemotherapy was not clear in this study. The high risk of pulmonary metastasis in this disease indicates the necessity of more effective adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalActa medica Okayama
Volume51
Issue number2
Publication statusPublished - Apr 1 1997

    Fingerprint

Keywords

  • Clinical analysis
  • Malignant schwannoma
  • Von Recklinghausen's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kunisada, T., Kawai, A., Ozaki, T., Sugihara, S., Taguchi, K., & Inoue, H. (1997). A Clinical Analysis of Malignant Schwannoma. Acta medica Okayama, 51(2), 87-92.