A Chicken WNT Gene, WNT-11, Is Involved in Dermal Development

N. Tanda, Hideyo Ohuchi, H. Yoshioka, S. Noji, T. Nohno

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We have isolated a new member of the Wnt gene family, Wnt-11, from chick embryo cDNA library and examined the expression pattern during embryogenesis by in situ hybridization. The Wnt-11 gene encodes Cys-rich secretory protein distantly related to Wnt-1 through Wnt-8 from the mouse and Xenopus. Expression of the Wnt-11 gene became evident at stage 14 in the dorsolateral region of somites and gradually restricted to the dermatome at stage 19 and later. In contrast to the other Wnt genes, Wnt-11 was not expressed in the neuroepithelium throughout stages 14-26. At stage 24 and later, Wnt-11 was expressed in the subectodermal mesenchyme of the limb and feather buds. The unique expression pattern of Wnt-11 in the paraxial mesoderm and dermatome suggests that Wnt-11 may play an important role in dermal development.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume211
Issue number1
DOIs
Publication statusPublished - Jun 6 1995
Externally publishedYes

Fingerprint

Chickens
Genes
Skin
Mesoderm
Limb Buds
Feathers
Somites
Chick Embryo
Xenopus
Gene Library
Embryonic Development
In Situ Hybridization
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

A Chicken WNT Gene, WNT-11, Is Involved in Dermal Development. / Tanda, N.; Ohuchi, Hideyo; Yoshioka, H.; Noji, S.; Nohno, T.

In: Biochemical and Biophysical Research Communications, Vol. 211, No. 1, 06.06.1995, p. 123-129.

Research output: Contribution to journalArticle

Tanda, N. ; Ohuchi, Hideyo ; Yoshioka, H. ; Noji, S. ; Nohno, T. / A Chicken WNT Gene, WNT-11, Is Involved in Dermal Development. In: Biochemical and Biophysical Research Communications. 1995 ; Vol. 211, No. 1. pp. 123-129.
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